Lucia Acampora
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View article: Deiodinases’ Inhibitors: A Double-Edged Sword
Deiodinases’ Inhibitors: A Double-Edged Sword Open
The deiodinase enzymes are the gatekeepers of the peripheral Thyroid Hormone (TH) metabolism since they catalyze the activation of the prohormone Thyroxine (T4) into the active Triiodothyronine (T3), as well as their inactivation into meta…
View article: Ursolic Acid-Based Nutraceutical Mitigates Muscle Atrophy and Improves Exercise Performance in Mouse Model of Peripheral Neuropathy
Ursolic Acid-Based Nutraceutical Mitigates Muscle Atrophy and Improves Exercise Performance in Mouse Model of Peripheral Neuropathy Open
Peripheral nerve injuries, caused by trauma or iatrogenic damage, often lead to permanent disabilities with limited effectiveness of current therapeutic treatments. This has driven the growing interest toward natural bioactive molecules, i…
View article: L’asse intestino-tiroide: come le alterazioni della barriera influenzano lo stato tiroideo
L’asse intestino-tiroide: come le alterazioni della barriera influenzano lo stato tiroideo Open
Sommario La barriera intestinale svolge un ruolo cruciale nel mantenimento dell’omeostasi dell’organismo, agendo come barriera multifunzionale sia contro agenti patogeni, sia nell’assorbimento di nutrienti. La barriera intestinale è costit…
View article: Digital-Driven Circular Ecosystems for the Textile Sector: Insights from a Survey on Sustainable Practices in Italy
Digital-Driven Circular Ecosystems for the Textile Sector: Insights from a Survey on Sustainable Practices in Italy Open
The textile industry is among the most environmentally impactful sectors, underscoring the urgency of transitioning to circular economy models. This study examines the development of a digital-driven circular ecosystem for the Italian text…
View article: Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells
Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells Open
Background: Thyroid Hormones (THs) critically impact human cancer. Although endowed with both tumor-promoting and inhibiting effects in different cancer types, excess of THs has been linked to enhanced tumor growth and progression. Breast …
View article: The thyroid hormone activating enzyme, DIO2, is a potential pan-cancer biomarker and immunotherapy target
The thyroid hormone activating enzyme, DIO2, is a potential pan-cancer biomarker and immunotherapy target Open
View article: Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of <i>ADAM12</i> and <i>CYP1B1</i>
Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of <i>ADAM12</i> and <i>CYP1B1</i> Open
Obesity exacerbates the risk and aggressiveness of many types of cancer. Adipose tissue (AT) represents a prevalent component of the tumor microenvironment (TME) and contributes to cancer development and progression. Reciprocal communicati…
View article: Thyroid Hormone Activation Drives Fibroblast Identity and Tumor Remodeling in Cutaneous Squamous Cell Carcinoma
Thyroid Hormone Activation Drives Fibroblast Identity and Tumor Remodeling in Cutaneous Squamous Cell Carcinoma Open
View article: AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation
AbaComplex Enhances Mitochondrial Biogenesis and Adipose Tissue Browning: Implications for Obesity and Glucose Regulation Open
Adipose tissue, particularly white adipose tissue (WAT), plays a central role in energy storage and metabolic regulation. Excess WAT, especially visceral fat, is strongly linked to metabolic disorders such as obesity and type 2 diabetes. T…
View article: Muscle PGC‐1α Overexpression Drives Metabolite Secretion Boosting Subcutaneous Adipocyte Browning
Muscle PGC‐1α Overexpression Drives Metabolite Secretion Boosting Subcutaneous Adipocyte Browning Open
Muscle and adipose tissue (AT) are in mutual interaction through the integration of endocrine and biochemical signals, thus regulating whole‐body function and physiology. Besides a traditional view of endocrine relationships that imply the…
View article: Low triiodothyronine is associated with high risk of malnutrition and poor functional status in subacute stroke patients
Low triiodothyronine is associated with high risk of malnutrition and poor functional status in subacute stroke patients Open
Altered fT3 levels in early subacute stroke patients correlate with high nutritional risk and poor functional status. Low fT3 values upon admission for stroke rehabilitation may serve as a further parameter to be considered in patients at …
View article: Thyroid Hormone Regulates the Lipid Content of Muscle Fibers, Thus Affecting Physical Exercise Performance
Thyroid Hormone Regulates the Lipid Content of Muscle Fibers, Thus Affecting Physical Exercise Performance Open
Skeletal muscle (SkM) lipid composition plays an essential role in physiological muscle maintenance and exercise performance. Thyroid hormones (THs) regulate muscle formation and fuel energy utilization by modulating carbohydrates and lipi…