Explanipedia

Global Incidence of Pertussis After the COVID-19 Pandemic Open

Andrew Gorringe, Breeze E. Cavell, Frank Beard, Keiko Tsukada, Nao Otsuka , et al. · 2025

Importance Pertussis, or whooping cough, is caused by the Bordetella pertussis bacterium. It induces prolonged cough in all age groups and is a severe, life-threatening disease in young infants. Observations In an online workshop organized…

Bordetella pertussis exhibits genomic diversity within patients and laboratory culture Open

Emilie Bouda, Yajun Peng, Margaret M. Williams, Pamela K. Cassiday, Tami H. Skoff , et al. · 2025

Over the past decade, genomic characterization of Bordetella pertussis isolates recovered from US pertussis patients has unveiled noteworthy structural gene order variations. Whole-genome sequencing (WGS) shows that although B. pertussis e…

P-1318. Epidemiology and Trends of Corynebacterium diphtheriae in the United States, 2016-2023 Open

Isha Berry, Valerie Bampoe, Matt Cole, Ju Yeon Hong, Ingrid C. McCall , et al. · 2025

Background Diphtheria, commonly resulting in severe respiratory or cutaneous disease, is caused by toxin-producing (i.e., toxigenic) strains of Corynebacterium diphtheriae. Non-toxigenic C. diphtheriae also cause disease, which is typicall…

Assessing the Impact of the 2020 Council of State and Territorial Epidemiologists Case Definition for Pertussis on Reported Pertussis Cases Open

Amy B Rubis, Matt Cole, M. Lucia Tondella, Lucia C. Pawloski, Erin Youngkin , et al. · 2024

Background In 2020, the Council of State and Territorial Epidemiologists (CSTE) pertussis case definition was modified; the main change was classifying polymerase chain reaction (PCR)-positive cases as confirmed, regardless of cough durati…

Genome-based prediction of cross-protective, HLA-DR-presented epitopes as putative vaccine antigens for multiple Bordetella species Open

Muktha S. Natrajan, Jesse M. Hall, Michael R. Weigand, Yanhui Peng, Margaret M. Williams , et al. · 2023

Acellular pertussis vaccines protect against severe pertussis, but vaccine-induced immunity wanes over time. Prior animal studies showed that T-cell responses are integral to long-lasting immunity. Current pertussis vaccines also do not pr…

Genomic characterization of cocirculating Corynebacterium diphtheriae and non-diphtheritic Corynebacterium species among forcibly displaced Myanmar nationals, 2017–2019 Open

Lingzi Xiaoli, Yanhui Peng, Margaret M. Williams, Marlon Lawrence, Pamela K. Cassiday , et al. · 2023

Respiratory diphtheria is a serious infection caused by toxigenic Corynebacterium diphtheriae , and disease transmission mainly occurs through respiratory droplets. Between 2017 and 2019, a large diphtheria outbreak among forcibly displace…

High post-exposure prophylaxis (PEP) uptake among household contacts of pertussis patients enrolled in a PEP effectiveness evaluation – United States, 2015–2017 Open

Lucy A. McNamara, Amy B. Rubis, Lucia C. Pawloski, Elizabeth C. Briere, Lara Misegades , et al. · 2023

Background Post-exposure prophylaxis (PEP) for pertussis is recommended for household contacts of pertussis cases in the United States within 21 days of exposure, but data on PEP effectiveness for prevention of secondary cases in the setti…

Evaluation of Serologic Cross-Reactivity Between Dengue Virus and SARS-CoV-2 in Patients with Acute Febrile Illness — United States and Puerto Rico, April 2020–March 2021 Open

Jorge L. Muñoz‐Jordán, Jaime Cardona, Manuela Beltrán, Candimar Colón, Jarad Schiffer , et al. · 2022

The diagnosis of dengue disease, caused by the dengue virus (DENV) (a flavivirus), often requires serologic testing during acute and early convalescent phases of the disease. Some symptoms of DENV infection, such as nonspecific fever, are …

Performance of existing and novel surveillance case definitions for COVID-19 in household contacts of PCR-confirmed COVID-19 Open

Hannah E. Reses, Mark Fajans, Scott Lee, Charles M. Heilig, Victoria Chu , et al. · 2021

Detection of SARS-CoV-2 on Surfaces in Households of Persons with COVID-19 Open

Perrine Marcenac, Geun Woo Park, Lindsey M. Duca, Nathaniel M. Lewis, Elizabeth A. Dietrich , et al. · 2021

SARS-CoV-2 transmission from contaminated surfaces, or fomites, has been a concern during the COVID-19 pandemic. Households have been important sites of transmission throughout the COVID-19 pandemic, but there is limited information on SAR…

Prevalence and characterization of pertactin deficient Bordetella pertussis strains in Brazil, a whole-cell vaccine country Open

Daniela Leite, Carlos Henrique Camargo, Suely Sanae Kashino, Ricardo Polatto, Luciano Moura Martins , et al. · 2021

Many countries have reported antigenic divergence among circulating Bordetella pertussis strains, mainly in those countries which introduced the acellular pertussis (aP) vaccine. This phenomenon can be seen, for example, with the re…

Effect of maternal Tdap on infant antibody response to a primary vaccination series with whole cell pertussis vaccine in São Paulo, Brazil Open

Lourdes R.A. Vaz-de-Lima, Ana Paula Sayuri Sato, Lucia C. Pawloski, Éder Gatti Fernandes, Gowrisankar Rajam , et al. · 2021

Elevated antibody levels suggest that maternal Tdap vaccination might protect infants until 2 months of age. Reduced anti-PT levels at 7 months indicate potential blunting of immune response in infants. Surveillance would help determine if…

Epidemiological Correlates of Polymerase Chain Reaction Cycle Threshold Values in the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Open

Phillip P. Salvatore, Patrick Dawson, Ashutosh Wadhwa, Elizabeth M. Rabold, Sean Buono , et al. · 2020

Background Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has principally been performed through the use of real-time reverse-transcription polymerase chain reaction testing. Results of such tests can b…

Household Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 in the United States Open

Nathaniel M. Lewis, Victoria Chu, Dongni Ye, Erin E. Conners, Radhika Gharpure , et al. · 2020

Background The evidence base for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is nascent. We sought to characterize SARS-CoV-2 transmission within US households and estimate the household secondary infection rate (SIR) to i…

Notes from the Field: Conjunctivitis Caused by Toxigenic Corynebacterium ulcerans — Missouri, 2018 Open

Lauren M. Weil, Cindy Butler, Karla R. Howell, Sarah Sharr, Grace Paley , et al. · 2019

Association between the timing of maternal vaccination and newborns’ anti-pertussis toxin antibody levels Open

Lourdes R.A. Vaz-de-Lima, Helena Keico Sato, Éder Gatti Fernandes, Ana Paula Sayuri Sato, Lucia C. Pawloski , et al. · 2019

Clinical evaluation and validation of laboratory methods for the diagnosis of Bordetella pertussis infection: Culture, polymerase chain reaction (PCR) and anti-pertussis toxin IgG serology (IgG-PT) Open

Adria D. Lee, Pamela K. Cassiday, Lucia C. Pawloski, Kathleen M. Tatti, Monte D. Martin , et al. · 2018

Timing of specimen collection in relation to onset of illness should be considered when ordering diagnostic tests for pertussis. Consideration should be given to including IgG-PT serology as a confirmatory test in the Council of State and …

Genomic Survey ofBordetella pertussisDiversity, United States, 2000–2013 Open

Michael R. Weigand, Margaret M. Williams, Yanhui Peng, Dane A. Kania, Lucia C. Pawloski , et al. · 2018

We characterized 170 complete genome assemblies from clinical Bordetella pertussis isolates representing geographic and temporal diversity in the United States. These data capture genotypic shifts, including increased pertactin deficiency,…

Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis Open

Michael R. Weigand, Lucia C. Pawloski, Yanhui Peng, Ju Yeon Hong, Mark Burroughs , et al. · 2018

Despite high vaccine coverage, pertussis cases in the United States have increased over the last decade. Growing evidence suggests that disease resurgence results, in part, from genetic divergence of circulating strain populations away fro…

Standard Operating Procedure for Real-time PCR Detection and Identification of Bordetella pertussis, B. parapertussis, and B. holmesii using AB7500 v1 Open

Adria D. Lee, Pamela K. Cassiday, Lucia C. Pawloski, Kathleen M. Tatti, Monte D. Martin , et al. · 2017

The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of differen…

Standard Operating Procedure for Culture Identification and Differentiation of Bordetella species v1 Open

Adria D. Lee, Pamela K. Cassiday, Lucia C. Pawloski, Kathleen M. Tatti, Monte D. Martin , et al. · 2017

The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of differen…

Standard Operating Procedure for the Detection of Human, IgG Anti-Pertussis Toxin v1 Open

Adria D. Lee, Pamela K. Cassiday, Lucia C. Pawloski, Kathleen M. Tatti, Monte D. Martin , et al. · 2017

The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of differen…

Expanding Pertussis Epidemiology in 6 Latin America Countries through the Latin American Pertussis Project Open

Veronica Pinell-McNamara, Anna M. Acosta, Maria Cristina Pedreira, Ana Flavia Carvalho, Lucia C. Pawloski , et al. · 2017

The Latin American Pertussis Project (LAPP), established in 2009, is a collaboration between the Centers for Disease Control and Prevention, Pan American Health Organization, Sabin Vaccine Institute, and the ministries of health of 6 count…

Standard Operating Procedure for Culturing Bordetella species from Nasopharyngeal Specimens v1 Open

Adria D. Lee, Pamela K. Cassiday, Lucia C. Pawloski, Kathleen M. Tatti, Monte D. Martin , et al. · 2017

The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of differen…

Development of a qualitative assay for screening of Bordetella pertussis isolates for pertussis toxin production Open

Irina V. Gates, Marina DuVall, Ju Yeon Hong, M. Lucia Tondella, Lucia C. Pawloski · 2017

Bordetella pertussis infection has been increasing in the US, with reported cases reaching over 50,000 in 2012, a number last observed in the 1950s. Concurrently, B. pertussis lacking the pertactin protein, one of the immunogens included i…

Risk Factors Associated With Bordetella pertussis Among Infants ≤4 Months of Age in the Pre-Tdap Era Open

C. Robinette Curtis, Andrew L. Baughman, Chas DeBolt, Susan Goodykoontz, Cynthia Kenyon , et al. · 2016

Background: In the United States, infants have the highest reported pertussis incidence and death rates. Improved understanding of infant risk factors is needed to optimize prevention strategies. Methods We prospectively enrolled infants ≤…

Evaluation of Commercial Assays for Single-Point Diagnosis of Pertussis in the US Open

Lucia C. Pawloski, Brian D. Plikaytis, Monte D. Martin, Stacey W. Martin, Harry E. Prince , et al. · 2016

Seroassays varied substantially under both analytical and clinical parameters; however, those that were calibrated to a reference standard were highly accurate. Our findings support incorporation of calibrated pertussis seroassays to the p…

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