Luís Costa
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View article: Simulating climate change scenarios established by the Intergovernmental Panel on Climate Change in aquatic mesocosms
Simulating climate change scenarios established by the Intergovernmental Panel on Climate Change in aquatic mesocosms Open
Climate change poses a major threat to ecosystems worldwide, with temperature changes being a key driver of ecological disruption in aquatic environments due to the limited ability of many aquatic species to relocate in response. Despite a…
View article: Risk Factors for Disease Recurrence in Patients with HER2+ Early Breast Cancer and Implications for Therapy: A Narrative Review
Risk Factors for Disease Recurrence in Patients with HER2+ Early Breast Cancer and Implications for Therapy: A Narrative Review Open
Human epidermal growth factor receptor 2 (HER2) overexpression or amplification of the human ERBB2 oncogene occurs in approximately one-fifth of breast cancers and, of these, two-thirds are hormone receptor (HR)-positive (HR+). The introdu…
View article: Perceptions and Factors Associated with Adherence to Cervical Cancer Screening Among Women in a Brazilian Municipality
Perceptions and Factors Associated with Adherence to Cervical Cancer Screening Among Women in a Brazilian Municipality Open
Background: Cervical Cancer (CC) is among the diseases with the greatest impact on female mortality worldwide. In Brazil, estimates from the National Cancer Institute for the 2020–2022 triennium indicate approximately 16,590 new cases, cor…
View article: Succinate Dehydrogenase B (SDHB) Overexpression with Enzymatic Dysfunction Defines a Distinct Subtype of Undifferentiated Pleomorphic Sarcoma
Succinate Dehydrogenase B (SDHB) Overexpression with Enzymatic Dysfunction Defines a Distinct Subtype of Undifferentiated Pleomorphic Sarcoma Open
Undifferentiated pleomorphic sarcoma (UPS) remains one of the most clinically aggressive and poorly characterized soft-tissue sarcoma subtypes. To uncover distinctive molecular traits for UPS, a multiomics analysis of UPS compared with lei…
View article: High-Resolution aCGH Analysis of the Jurkat Cell Line: Copy Number Alterations and Their Association With Cancer Hallmarks
High-Resolution aCGH Analysis of the Jurkat Cell Line: Copy Number Alterations and Their Association With Cancer Hallmarks Open
These findings suggest that Jurkat cells may serve as a valuable model for identifying new targets for cancer research. Further studies are required to confirm the phenotypic implications of these variants, which may open new avenues for e…
View article: Predicting Pathological Complete Response in HER2+ Breast Cancer: An AI-Driven Model Using Standard Clinical Practice Parameters
Predicting Pathological Complete Response in HER2+ Breast Cancer: An AI-Driven Model Using Standard Clinical Practice Parameters Open
IntroductionIn breast carcinoma (BC), particularly the HER2 + subtype, achieving a complete pathological response (pCR) after neoadjuvant therapy (NAT) is vital for prognosis and disease-free survival. While dual HER2 blockade with trastuz…
View article: Human Rights, Economic Rights, Socio-Cultural Rights: A Critical Analysis of Law No. 4/2012 on Employment in Timor Leste
Human Rights, Economic Rights, Socio-Cultural Rights: A Critical Analysis of Law No. 4/2012 on Employment in Timor Leste Open
This study aims to determine Human Rights, Economic Rights, Socio-Cultural Rights: Critical Analysis of Law No. 4 of 2012 concerning Manpower in Timor Leste. The results of this study indicate that Through an inclusive and strategic approa…
View article: Valuation of the Knowledge of Women of Childbearing Age from Caratateua Island, Outeiro District, regarding HPV Infection
Valuation of the Knowledge of Women of Childbearing Age from Caratateua Island, Outeiro District, regarding HPV Infection Open
Introduction: Human papillomavirus (HPV) is a common sexually transmitted infection linked to cervical cancer. Despite the availability of preventive measures, many women of childbearing age still lack adequate knowledge about the virus. O…
View article: Succinate dehydrogenase B (SDHB) overexpression with enzymatic dysfunction defines a distinct subtype of undifferentiated pleomorphic sarcoma
Succinate dehydrogenase B (SDHB) overexpression with enzymatic dysfunction defines a distinct subtype of undifferentiated pleomorphic sarcoma Open
Undifferentiated pleomorphic sarcoma (UPS) remains one of the most clinically aggressive and poorly characterized soft tissue sarcoma (STS) subtypes. To uncover distinctive molecular traits for UPS, a multi-omics analysis of UPS compared t…
View article: Profile of the Knowledge of SUS (Unified Health System) Users in the City of BELÉM/PA in Relation to Home Care - Better at Home Program
Profile of the Knowledge of SUS (Unified Health System) Users in the City of BELÉM/PA in Relation to Home Care - Better at Home Program Open
Objective: To investigate the knowledge profile of users of the Unified Health System in the city of Belém/PA in relation to home care - Better at Home Program. Methods: This is a descriptive research, with a quantitative approach, using o…
View article: CDK4/6 Inhibitors-Induced Macrocytosis Is Not Associated with Hemolysis and Does Not Impact Hemoglobin Homeostasis
CDK4/6 Inhibitors-Induced Macrocytosis Is Not Associated with Hemolysis and Does Not Impact Hemoglobin Homeostasis Open
Background: CDK 4/6 inhibitors (CDK4/6is) are the first-line treatment for metastatic luminal-like breast cancer (BC). These drugs induce macrocytosis without anemia in most patients. The mechanism for the red blood cell (RBC) changes is u…
View article: Avelumab Maintenance Therapy in Advanced Urothelial Carcinoma: Implications of Timing and Treatment Sequencing
Avelumab Maintenance Therapy in Advanced Urothelial Carcinoma: Implications of Timing and Treatment Sequencing Open
Background: Platinum-based chemotherapy (PBC) followed by avelumab maintenance is a treatment option for patients with advanced urothelial carcinoma (aUC) patients. However, the optimal treatment sequencing in the era of antibody–drug conj…
View article: Machine learning-based analysis of genomic and transcriptomic data unveils sarcoma clusters with superlative prognostic and predictive value
Machine learning-based analysis of genomic and transcriptomic data unveils sarcoma clusters with superlative prognostic and predictive value Open
Soft tissue sarcomas (STS) histopathological classification system has several conceptual caveats, impacting prognostication and treatment. The clinical and molecular-based tools currently employed to estimate prognosis also have limitatio…
View article: RANK pathway inhibition sensitizes triple-negative breast cancer to CDK4/6 inhibitors and enhances immune response
RANK pathway inhibition sensitizes triple-negative breast cancer to CDK4/6 inhibitors and enhances immune response Open
Despite chemotherapy's limitations and toxic effects, it remains the primary treatment for most triple-negative breast cancer (TNBC) patients. While cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy have revo…
View article: Impact of Bone Metastasis in Stage IV Non–Small Cell Lung Cancer Treated With Durvalumab and Tremelimumab With or Without Chemotherapy: A Retrospective Analysis of the CCTG BR.34 Trial
Impact of Bone Metastasis in Stage IV Non–Small Cell Lung Cancer Treated With Durvalumab and Tremelimumab With or Without Chemotherapy: A Retrospective Analysis of the CCTG BR.34 Trial Open
PURPOSE This retrospective analysis examines the impact of bone metastasis on outcomes in patients with non–small cell lung cancer (NSCLC) from the CCTG BR.34 trial, which investigated the combined immune checkpoint blockade. MATERIALS AND…
View article: A Randomized Controlled Trial Assessing the Release of Circulating Tumor and Mesenchymal Cells in No-Touch Radical Nephrectomy
A Randomized Controlled Trial Assessing the Release of Circulating Tumor and Mesenchymal Cells in No-Touch Radical Nephrectomy Open
Background: Circulating tumor cells (CTCs) may be the missing renal cell carcinoma (RCC) biomarker. No-touch (NT) resection has shown benefit in several tumors. Methods: A randomized controlled trial comparing CTC and circulating mesenchym…
View article: Renal cell carcinoma with inferior vena cava thrombus: Survival and prognostic factors in surgically treated patients
Renal cell carcinoma with inferior vena cava thrombus: Survival and prognostic factors in surgically treated patients Open
Introduction: Renal cell carcinoma (RCC) often develops a tumor thrombus extending into the inferior vena cava (IVC). Radical nephrectomy with IVC thrombectomy is the standard treatment, although prognostic factors are yet to be properly e…
View article: Interaction Between Climate Change Scenarios and Biological Invasion Reveals Complex Cascading Effects in Freshwater Ecosystems
Interaction Between Climate Change Scenarios and Biological Invasion Reveals Complex Cascading Effects in Freshwater Ecosystems Open
Climate change often facilitates biological invasions, leading to potential interactive impacts of these global drivers on freshwater ecosystems. Although climatic mitigation efforts may reduce the magnitude of these interactive impacts, w…
View article: Biomarker Profiling of Upper Tract Urothelial Carcinoma Only and with Synchronous or Metachronous Bladder Cancer
Biomarker Profiling of Upper Tract Urothelial Carcinoma Only and with Synchronous or Metachronous Bladder Cancer Open
Background: Molecular profiling in upper tract urothelial carcinoma (UTUC) with synchronous or metachronous urothelial bladder cancer (UBC) is scarce. We intended to assess immunohistochemical (IHC) and genetic differences between UTUC-onl…
View article: Effect of Cyclin-Dependent Kinase 4/6 Inhibitors on Circulating Cells in Patients with Metastatic Breast Cancer
Effect of Cyclin-Dependent Kinase 4/6 Inhibitors on Circulating Cells in Patients with Metastatic Breast Cancer Open
The combination of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with endocrine therapy (ET) is the standard-of-care for estrogen receptor (ER)-positive, HER2-negative (ER+/HER2− advanced/metastatic breast cancer (mBC). However, the imp…
View article: DNA damage targeted therapy for advanced breast cancer
DNA damage targeted therapy for advanced breast cancer Open
Breast cancer (BC) is the most prevalent malignancy affecting women worldwide, including Portugal. While the majority of BC cases are sporadic, hereditary forms account for 5-10% of cases. The most common inherited mutations associated wit…
View article: 81P Early access program: The reality of a Portuguese oncology center
81P Early access program: The reality of a Portuguese oncology center Open
Innovative targeted therapies are being developed rapidly, with new trials providing evidence almost continuously. Even though the European Medicines Agency (EMA) makes efforts to expedite their review and approval, individual countries ha…