Luciano C. Greig
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View article: Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms
Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms Open
Summary Both cell-intrinsic competency and extracellular cues regulate axon projection, but mechanisms that coordinate these elements remain poorly understood. Subcerebral projection neurons (SCPN) extend their primary axons from cortex th…
View article: Author response: Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms
Author response: Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms Open
View article: Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms
Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms Open
Summary Both cell-intrinsic competency and extracellular cues regulate axon projection, but mechanisms that coordinate these elements remain poorly understood. Subcerebral projection neurons (SCPN) extend their primary axons from cortex th…
View article: Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms
Bcl11b orchestrates subcerebral projection neuron axon development via cell-autonomous, non-cell-autonomous, and subcellular mechanisms Open
SUMMARY Both cell-intrinsic competency and extracellular cues regulate axon projection, but mechanisms that coordinate these elements remain poorly understood. Subcerebral projection neurons (SCPN) extend their primary axons from cortex th…
View article: BEAM: A combinatorial recombinase toolbox for binary gene expression and mosaic genetic analysis
BEAM: A combinatorial recombinase toolbox for binary gene expression and mosaic genetic analysis Open
We describe a binary expression aleatory mosaic (BEAM) system, which relies on DNA delivery by transfection or viral transduction along with nested recombinase activity to generate two genetically distinct, non-overlapping populations of c…
View article: Symmetry in levels of axon-axon homophilic adhesion establishes topography in the corpus callosum and development of connectivity between brain hemispheres
Symmetry in levels of axon-axon homophilic adhesion establishes topography in the corpus callosum and development of connectivity between brain hemispheres Open
Specific and highly diverse connectivity between functionally specialized regions of the nervous system is controlled at multiple scales, from anatomically organized connectivity following macroscopic axon tracts to individual axon target-…
View article: Anterior plaque brachytherapy placement for treatment of iris and iridociliary melanomas – Surgical procedure and institutional experience
Anterior plaque brachytherapy placement for treatment of iris and iridociliary melanomas – Surgical procedure and institutional experience Open
Surgical placement of eye plaque brachytherapy (EPB) is the standard of care for the treatment of uveal melanomas, including iris/iridociliary melanomas. However, unique challenges exist in anterior EPB placement. Here, we describe a surgi…
View article: Intrinsic and Induced Neuronal Regeneration in the Mammalian Retina
Intrinsic and Induced Neuronal Regeneration in the Mammalian Retina Open
Significance: Retinal neurons are vulnerable to disease and injury, which can result in neuronal death and degeneration leading to irreversible vision loss. The human retina does not regenerate to replace neurons lost to dise…
View article: BEAM: a combinatorial recombinase toolbox for binary gene expression and mosaic analysis
BEAM: a combinatorial recombinase toolbox for binary gene expression and mosaic analysis Open
Genetic mosaic analysis, in which mutant cells reside intermingled with wild-type cells, is a powerful experimental approach, but has not been widely used in mice because existing genome-based strategies require complicated and protracted …
View article: ASD gene <i>Bcl11a</i> regulates subcellular RNA localization, associative circuitry, and social behavior
ASD gene <i>Bcl11a</i> regulates subcellular RNA localization, associative circuitry, and social behavior Open
Precise, area-specific connectivity of interhemispheric callosal projection neurons (CPN) in the cerebral cortex is critical for sensory, associative, and behavioral functions. CPN circuitry, which connects and integrates the cerebral hemi…
View article: Multimodal imaging reveals retinoschisis masquerading as retinal detachment in patients with choroideremia
Multimodal imaging reveals retinoschisis masquerading as retinal detachment in patients with choroideremia Open
View article: Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting
Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting Open
View article: Defining multiplicity of plasmid electroporation in the retina for high-throughput genetic screening
Defining multiplicity of plasmid electroporation in the retina for high-throughput genetic screening Open
View article: Strict in vivo specificity of the Bcl11a erythroid enhancer
Strict in vivo specificity of the Bcl11a erythroid enhancer Open
Key Points Deletion of the erythroid enhancer of Bcl11a from the mouse genome does not affect viability or Bcl11a expression in nonerythroid lineages. Elevated levels of γ-globin in Bcl11a enhancer–deleted mice are comparable to those in e…
View article: Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers
Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers Open
View article: Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex
Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex Open