Luciano Hoeher
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View article: A Novel Tamoxifen-Inducible Mct8-CreERT2 Mouse Model for Targeted Studies of Mct8-Expressing Cells and Thyroid Hormone Transport and Function
A Novel Tamoxifen-Inducible Mct8-CreERT2 Mouse Model for Targeted Studies of Mct8-Expressing Cells and Thyroid Hormone Transport and Function Open
Deficiency of the Monocarboxylate Transporter 8 (MCT8) severely impairs thyroid hormone (TH) transport into the brain, disrupting brain development as well as peripheral TH homeostasis. Studies assessing MCT8 expression patterns and tissue…
View article: Deep Learning and 3D Imaging Reveal Whole-Body Alterations in Obesity
Deep Learning and 3D Imaging Reveal Whole-Body Alterations in Obesity Open
Many diseases, such as obesity, have systemic effects that impact multiple organ systems throughout the body. However, tools for comprehensive, high-resolution analysis of disease-associated changes at the whole-body scale have been lackin…
View article: Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution Open
Various cellular sources hamper interpretation of positron emission tomography (PET) biomarkers in the tumor microenvironment (TME). We developed an approach of immunomagnetic cell sorting after in vivo radiotracer injection (scRadiotracin…
View article: Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease Open
Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from …
View article: Whole-body cellular mapping in mouse using standard IgG antibodies
Whole-body cellular mapping in mouse using standard IgG antibodies Open
Whole-body imaging techniques play a vital role in exploring the interplay of physiological systems in maintaining health and driving disease. We introduce wildDISCO, a new approach for whole-body immunolabeling, optical clearing and imagi…
View article: Virtual reality empowered deep learning analysis of brain activity
Virtual reality empowered deep learning analysis of brain activity Open
Tissue clearing and fluorescent microscopy are powerful tools for unbiased organ-scale protein expression studies. Critical for interpreting expression patterns of large imaged volumes are reliable quantification methods. Here, we present …
View article: Whole mouse body histology using standard IgG antibodies
Whole mouse body histology using standard IgG antibodies Open
Most diseases involve multiple interconnected physiological systems, but histological evaluation of their pathology is currently limited to small tissue samples. Here, we present wildDISCO, a technology that uses cholesterol extraction to …
View article: Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution Open
Various cellular sources hamper interpretation of positron-emission-tomography (PET) biomarkers in the tumor microenvironment (TME). We developed immunomagnetic cell sorting after in vivo radiotracer injection (scRadiotracing) in combinati…