Lucie Kučerová
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View article: Mutation in Drosophila concentrative nucleoside transporter 1 alters spermatid maturation and mating behavior
Mutation in Drosophila concentrative nucleoside transporter 1 alters spermatid maturation and mating behavior Open
Concentrative nucleoside transporters (Cnts) are unidirectional carriers that mediate the energy-costly influx of nucleosides driven by the transmembrane sodium gradient. Cnts are transmembrane proteins that share a common structural organ…
View article: How safe/dangerous is working with cytostatics? Monitoring of contamination of the working environment with the cytostatic drugs at the Brno University Hospital
How safe/dangerous is working with cytostatics? Monitoring of contamination of the working environment with the cytostatic drugs at the Brno University Hospital Open
SDĚLENÍ Z KONFERENCEJak nebezpečná je práce s cytostatiky?Monitoring kontaminace pracovního prostředí cytostatickými léčivy ve FN Brno How safe/dangerous is with
View article: Comparison of Silks from Pseudoips prasinana and Bombyx mori Shows Molecular Convergence in Fibroin Heavy Chains but Large Differences in Other Silk Components
Comparison of Silks from Pseudoips prasinana and Bombyx mori Shows Molecular Convergence in Fibroin Heavy Chains but Large Differences in Other Silk Components Open
Many lepidopteran larvae produce silk feeding shelters and cocoons to protect themselves and the developing pupa. As caterpillars evolved, the quality of the silk, shape of the cocoon, and techniques in forming and leaving the cocoon under…
View article: Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila
Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila Open
Adenosine (Ado) is an important signaling molecule involved in stress responses. Studies in mammalian models have shown that Ado regulates signaling mechanisms involved in “danger-sensing” and tissue-protection. Yet, little is known about …
View article: Physiological Tradeoffs of Immune Response Differs by Infection Type in Pieris napi
Physiological Tradeoffs of Immune Response Differs by Infection Type in Pieris napi Open
Understanding the tradeoffs that result from successful infection responses is central to understanding how life histories evolve. Gaining such insights, however, can be challenging, as they may be pathogen specific and confounded with exp…
View article: N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers
N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers Open
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds conta…
View article: Adenosine receptor and its downstream targets, mod(mdg4) and Hsp70, work as a signaling pathway modulating cytotoxic damage in<i>Drosophila</i>
Adenosine receptor and its downstream targets, mod(mdg4) and Hsp70, work as a signaling pathway modulating cytotoxic damage in<i>Drosophila</i> Open
Summary Adenosine (Ado) is an important signaling molecule involved in stress responses. Studies in mammalian models have shown that Ado regulates signaling mechanisms involved in ‘danger-sensing’ and tissue-protection. Yet, little is know…
View article: Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions
Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions Open
Imaginal disc growth factors (IDGFs) are a small protein family found in insects. They are related to chitinases and implicated in multiple functions, including cell growth stimulation, antimicrobial activity, insect hemolymph clotting, an…
View article: Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses
Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses Open
The pathogenic effect of mutant HTT (mHTT) which causes Huntington disease (HD) are not restricted to nervous system. Such phenotypes include aberrant immune responses observed in the HD models. However, it is still unclear how this immune…
View article: The consequences of surviving infection across the metamorphic boundary: tradeoff insights from RNAseq and life history measures
The consequences of surviving infection across the metamorphic boundary: tradeoff insights from RNAseq and life history measures Open
The broad diversity of insect life has been shaped, in part, by pathogen pressure, yet the influence of injury and infection during critical periods of development is understudied. During development, insects undergo metamorphosis, wherein…
View article: Modular structure, sequence diversification and appropriate nomenclature of seroins produced in the silk glands of Lepidoptera
Modular structure, sequence diversification and appropriate nomenclature of seroins produced in the silk glands of Lepidoptera Open
View article: The expansion of genes encoding soluble silk components in the greater wax moth, Galleria mellonella
The expansion of genes encoding soluble silk components in the greater wax moth, Galleria mellonella Open
Lepidopteran silk is a complex assembly of proteins produced by a pair of highly specialized labial glands called silk glands. Silk composition has been examined only in a handful of species. Here we report on the analysis of silk gland-sp…
View article: Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity
Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity Open
View article: Collective farming in the memories of Czechoslovak agriculture workers
Collective farming in the memories of Czechoslovak agriculture workers Open
The present paper focuses on countryside life after the collectivization of agriculture and on the changes of the work processes there during the so-called normalization (1969–1987). It is based on narrative interviews with the then Czecho…
View article: Characterization of Reproductive Dormancy in Male Drosophila melanogaster
Characterization of Reproductive Dormancy in Male Drosophila melanogaster Open
Insects are known to respond to seasonal and adverse environmental changes by entering dormancy, also known as diapause. In some insect species, including Drosophila melanogaster, dormancy occurs in the adult organism and postpones …
View article: Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster
Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster Open
We find that many affected genes and signal pathways are shared between dormancy, aging and lifespan extension, including IIS, TOR, JAK/STAT and JNK. A substantial fraction of the genes affected by diapause have also been found to alter th…
View article: Additional file 12: Dataset S2. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster
Additional file 12: Dataset S2. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster Open
List of genes shared between diapause and response to restricted diet in D. melanogaster. We compared our study of three weeks diapause (3wD) to that of an analysis of effects of restricted diet (RF) [145]. Significantly inhibited transcri…
View article: Additional file 3: Dataset S1. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster
Additional file 3: Dataset S1. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster Open
Gene list of significantly regulated probes and reciprocal comparison. Transcripts that are significantly altered more than two-fold (|log2FC| ≥ 1, q ≤ 0.05) are shown. 3wDvs1wN represent transcripts regulated upon 3 weeks of diapause comp…
View article: Additional file 13: Dataset S3. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster
Additional file 13: Dataset S3. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster Open
Gene set enrichment analysis (GSEA) of GO terms comparing diapause and response to restricted diet in D. melanogaster. We compare our study of three weeks diapause (3wD) to that of an analysis of effects of restricted diet (RF) [145]. (A) …
View article: Additional file 14: Dataset S4. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster
Additional file 14: Dataset S4. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster Open
Comparisons of diapause response genes from our study of D. melanogaster with other transcription studies on reproductive diapause. We compared our study to a D. montana candidate gene microarray study [149] and Culex pipiens diapause resp…
View article: Additional file 9: Table S4. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster
Additional file 9: Table S4. of Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster Open
Genes affected by 3 weeks diapause compared to ones implicated in aging and increased longevity. Microarray study of aging response genes [136], longevity mapping study [33], transcriptome changes in mated and non-mated aging females [7] a…
View article: The <b><i>Drosophila</i></b> Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing
The <b><i>Drosophila</i></b> Chitinase-Like Protein IDGF3 Is Involved in Protection against Nematodes and in Wound Healing Open
Chitinase-like proteins (CLPs) of the 18 glycosyl hydrolase family retain structural similarity to chitinases but lack enzymatic activity. Although CLPs are upregulated in several human disorders that affect regenerative and inflammatory p…
View article: Standard fly medium supplemented with arginine (NOS substrate) increased melanization and lamellocytes in pro-tumor model.
Standard fly medium supplemented with arginine (NOS substrate) increased melanization and lamellocytes in pro-tumor model. Open
Dominant active Ras (RasV12)-expressing larvae showed increased penetrance of melanization and lamellocyte formation (expressed as the relative frequency of lamellocytes) upon feeding the NO donor L-arginine.
View article: Apoptosis in Hemocytes Induces a Shift in Effector Mechanisms in the Drosophila Immune System and Leads to a Pro-Inflammatory State
Apoptosis in Hemocytes Induces a Shift in Effector Mechanisms in the Drosophila Immune System and Leads to a Pro-Inflammatory State Open
Apart from their role in cellular immunity via phagocytosis and encapsulation, Drosophila hemocytes release soluble factors such as antimicrobial peptides, and cytokines to induce humoral responses. In addition, they participate in coagula…
View article: Removal of PAHs from Sewage Sludge
Removal of PAHs from Sewage Sludge Open
The aim of this research is to reduce the quantities of polyaromatic hydrocarbons (PAHs) in the samples of non-hygienised sewage sludge via laboratory biodegradation. A bacterial mixture of Pseudomonas putida and Rhodococcus sp. has been u…
View article: Quality Assessment of Detail in Wooden House Critical connection of the wall and the ceiling construction
Quality Assessment of Detail in Wooden House Critical connection of the wall and the ceiling construction Open
The development of thermal insulation materials that can be used in modern wooden houses noticed a large shift.But there are also some negative aspects which affect long-term quality of the thermal insulation properties.Influences as poor …