Lucien F. Harthoorn
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View article: Galacto-Oligosaccharides Exert Bifidogenic Effects at Capsule-Compatible Ultra-Low Doses
Galacto-Oligosaccharides Exert Bifidogenic Effects at Capsule-Compatible Ultra-Low Doses Open
Background: Prebiotics are selectively used by host microorganisms to promote health. Because effective prebiotic doses (1.5–30 g/day) often require inconvenient delivery formats, this study aims to explore whether capsule-compatible doses…
View article: Prebiotics in food and dietary supplements: a roadmap to EU health claims
Prebiotics in food and dietary supplements: a roadmap to EU health claims Open
Numerous studies have established that prebiotic ingredients in foods and dietary supplements may play a role in supporting human health. Over the three decades that have passed since prebiotics were first defined as a concept, research ha…
View article: Galactooligosaccharide (GOS) Reduces Branched Short-Chain Fatty Acids, Ammonium, and pH in a Short-Term Colonic Fermentation Model
Galactooligosaccharide (GOS) Reduces Branched Short-Chain Fatty Acids, Ammonium, and pH in a Short-Term Colonic Fermentation Model Open
Prebiotics beneficially affect the gut microbiome. Bimuno®, a prebiotic supplement containing galactooligosaccharides (GOS), has multiple demonstrated prebiotic effects. Using short-term colonic incubations, the influence of GOS on the col…
View article: Galactooligosaccharide Treatment Alleviates DSS-Induced Colonic Inflammation in Caco-2 Cell Model
Galactooligosaccharide Treatment Alleviates DSS-Induced Colonic Inflammation in Caco-2 Cell Model Open
The biological activities of dietary bioactive polysaccharides have been largely explored. Studies on the immunomodulating effects of oligosaccharides and polysaccharides have shown that they are able to modulate innate immunity. Prebiotic…
View article: The Habitual Diet of Dutch Adult Patients with Eosinophilic Esophagitis Has Pro-Inflammatory Properties and Low Diet Quality Scores
The Habitual Diet of Dutch Adult Patients with Eosinophilic Esophagitis Has Pro-Inflammatory Properties and Low Diet Quality Scores Open
We determined the nutritional adequacy and overall quality of the diets of adult patients with eosinophilic esophagitis (EoE). Dietary intakes stratified by sex and age were compared to Dietary Reference Values (DRV). Overall diet quality …
View article: Development of a self-limiting model of Methotrexate-induced mucositis reinforces butyrate as a potential therapy
Development of a self-limiting model of Methotrexate-induced mucositis reinforces butyrate as a potential therapy Open
Background: Gastrointestinal mucositis remains a significant complication of anticancer treatment, with limited anti-mucositis interventions. Currently, there are few validated in vitro systems suitable to study the mechanisms of mucosal i…
View article: Mineral Intake and Status of Cowʼs Milk Allergic Infants Consuming an Amino Acid-based Formula:
Mineral Intake and Status of Cowʼs Milk Allergic Infants Consuming an Amino Acid-based Formula: Open
Data on the mineral status of infants with cow's milk allergy (CMA) consuming an amino acid-based formula (AAF) have not been published. The present study aims to assess mineral status of term infants age 0 to 8 months diagnosed with CMA r…
View article: A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey
A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey Open
Background Amino acid‐based formulas (AAFs) are used for the dietary management of cow's milk allergy (CMA). Whether AAFs have the potential to prevent the development and/or symptoms of CMA is not known. Objective The present study evalua…
View article: Network-Based Selection of Candidate Markers and Assays to Assess the Impact of Oral Immune Interventions on Gut Functions
Network-Based Selection of Candidate Markers and Assays to Assess the Impact of Oral Immune Interventions on Gut Functions Open
To assess the safety and efficacy of oral immune interventions, it is important and required by regulation to assess the impact of those interventions not only on the immune system, but also on other organs such as the gut as the porte d'e…
View article: Cow's Milk Allergic Infants on Elemental Formula Maintain Adequate Mineral Status Despite Using Acid‐suppressive Drugs
Cow's Milk Allergic Infants on Elemental Formula Maintain Adequate Mineral Status Despite Using Acid‐suppressive Drugs Open
To the Editor: We recently presented data in this Journal showing that cow's milk allergic infants who received an amino acid–based formula (AAF) for 16 weeks as oral feeding had adequate mineral status (1). One factor that may negatively …
View article: A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial
A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial Open
The AAF including specific synbiotics effectively modulates the gut microbiota and its metabolic activity in non-IgE mediated CMA infants bringing it close to a healthy breastfed profile.Trial registration Registered on 1 May 2013 with Net…
View article: Gut microbiota from infant with cow’s milk allergy promotes clinical and immune features of atopy in a murine model
Gut microbiota from infant with cow’s milk allergy promotes clinical and immune features of atopy in a murine model Open
To the Editor, Numerous clinical and epidemiological studies suggest an association between abnormal development of the gut microbiota in early life and development of clinical manifestations related to allergy including cow's milk allergy…
View article: A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial
A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial Open
Beneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26 weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.Trial Registration NTR3979.
View article: The relationship of habitual diet with esophageal inflammation and integrity in eosinophilic esophagitis
The relationship of habitual diet with esophageal inflammation and integrity in eosinophilic esophagitis Open
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View article: P35: ACID‐BASED FORMULA WITH SYNBIOTICS MODIFIES GUT MICROBIOTA IN NON‐IGE MEDIATED COW’S MILK ALLERGIC INFANTS
P35: ACID‐BASED FORMULA WITH SYNBIOTICS MODIFIES GUT MICROBIOTA IN NON‐IGE MEDIATED COW’S MILK ALLERGIC INFANTS Open
Cow’s milk allergy (CMA) is associated with an aberrant gut microbiota in early life. Non-IgE mediated CMA is less well understood and symptoms are complex. Previously, it was shown that gut microbiota of non-IgE mediated CMA infants becam…
View article: Mineral Intake and Status of Cow's Milk Allergic Infants Consuming an Amino Acid‐based Formula
Mineral Intake and Status of Cow's Milk Allergic Infants Consuming an Amino Acid‐based Formula Open
Data on the mineral status of infants with cow's milk allergy (CMA) consuming an amino acid‐based formula (AAF) have not been published. The present study aims to assess mineral status of term infants age 0 to 8 months diagnosed with CMA r…
View article: Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet
Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet Open
An elemental diet restores esophageal integrity, suggesting that it is at least partly secondary to allergen exposure. Duodenal integrity seems not to be affected in EoE, and possibly plays a minor role in its pathophysiology.
View article: Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients
Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients Open
Summary Background Eosinophilic oesophagitis (EoE) is a chronic disease, driven by food allergens. Elemental diets are effective for the management of children with EoE, but studies on the effect of elemental diets in adults are scarce and…
View article: Post‐sensitization administration of non‐digestible oligosaccharides and <i>Bifidobacterium breve</i> M‐16V reduces allergic symptoms in mice
Post‐sensitization administration of non‐digestible oligosaccharides and <i>Bifidobacterium breve</i> M‐16V reduces allergic symptoms in mice Open
To support dietary management of severe cow's milk allergic infants, a synbiotic mixture of non‐digestible oligosaccharides and Bifidobacterium breve M‐16V ( B. breve ) was designed from source materials that are completely cow's milk‐free…