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View article: Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse
Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse Open
View article: Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR
Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR Open
The tumor microenvironment promotes cancer progression in part by supporting cancer stem cells (CSC). In colorectal cancer (CRC), progastrin (PG), an orphan growth factor secreted by tumor cells within the tumor and its microenvironment, m…
View article: Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation
Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation Open
Tumor initiating cells (TICs) are the roots of current shortcomings in advanced and metastatic cancer treatment. Endowed with self-renewal and multi-lineage differentiation capacity, TICs can disseminate and seed metastasis in distant orga…
View article: Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer
Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer Open
The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity. Through a high-throughput drug repositioning screen…
View article: Inhibition of STAT3/Fanconi anemia axis by Nifuroxazide is synthetic lethal with PARP inhibitor and selectively targets breast cancer stem cells
Inhibition of STAT3/Fanconi anemia axis by Nifuroxazide is synthetic lethal with PARP inhibitor and selectively targets breast cancer stem cells Open
The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity. Through a high-throughput drug repositioning screen…
View article: A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse
A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse Open
Tumor recurrence is often attributed to drug-tolerant cancer stem cells. We previously demonstrated that down regulation of the Pregnane X Receptor (PXR, NR1I2) decreases chemoresistance of cancer stem cells and prevents colorectal cancer …
View article: Early Dissemination Highly Enhances Liver Metastasis Development During Intestinal Tumorigenesis
Early Dissemination Highly Enhances Liver Metastasis Development During Intestinal Tumorigenesis Open
View article: The aminoglycoside streptomycin triggers ferroptosis in tumor initiating cells
The aminoglycoside streptomycin triggers ferroptosis in tumor initiating cells Open
Compelling evidence suggests that tumor initiating cells (TIC) are the roots of current shortcomings in advanced and metastatic cancer treatment. TIC represents a minor subpopulation of tumor cells endowed with self-renewal and multi-linea…
View article: Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy
Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy Open
View article: The Aminoglycoside Streptomycin Triggers Ferroptosis in Tumor Initiating Cells
The Aminoglycoside Streptomycin Triggers Ferroptosis in Tumor Initiating Cells Open