Lucile Drujont
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View article: Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation
Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation Open
Psoriasis is a chronic inflammatory disease resulting from dysregulated immune activation associated with a large local secretion of cytokines. Among them, IL-22 largely contributes to epithelial remodeling and inflammation through inhibit…
View article: RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus Open
Retinoid-related orphan receptor gamma t (RORγt) is a master transcription factor central to type 17 immunity involving cells such as T helper 17, group 3 innate lymphoid cells or IL-17-producing γδ T cells. Here we show that the intracell…
View article: Adoptive transfer of BM-derived MDSC is associated with increased numbers of MHC II<sup>+</sup> and CD86<sup>+</sup> cells, mainly in the spleen.
Adoptive transfer of BM-derived MDSC is associated with increased numbers of MHC II<sup>+</sup> and CD86<sup>+</sup> cells, mainly in the spleen. Open
Male skin grafts were transplanted onto females recipients treated or not at days −1, 6 and 13 post-transplantation with four million autologous (female) MDSC generated in vitro with GM-CSF and IL-6. Draining lymph nodes and spleen were ha…
View article: Phenotype of BM-derived MDSC.
Phenotype of BM-derived MDSC. Open
(A) BM cells from naive mice were cultured in the presence of GM-CSF and IL-6 for 4 days. Surface expression of CD11b and Gr1 was measured by flow cytometry. (B) Quantification of the relative proportions of CD11b+ Gr1hi
View article: Adoptive transfer of BM-derived MDSC does not prevent the development of autoimmune diabetes.
Adoptive transfer of BM-derived MDSC does not prevent the development of autoimmune diabetes. Open
Type 1 diabetes was induced in RIP-mOVA mice by injecting (i.v.) naive CD8+ T cells from OT-1 TCR-transgenic mice together with an anti-OVA polyclonal antibody (i.p.). Blood glycemia was monitored every day during at least 12 da…
View article: Combining α-Radioimmunotherapy and Adoptive T Cell Therapy to Potentiate Tumor Destruction
Combining α-Radioimmunotherapy and Adoptive T Cell Therapy to Potentiate Tumor Destruction Open
Ionizing radiation induces direct and indirect killing of cancer cells and for long has been considered as immunosuppressive. However, this concept has evolved over the past few years with the demonstration that irradiation can increase tu…