Lucilene Delazari dos Santos
YOU?
Author Swipe
View article: Effects of heat stress on serum proteomics, laying performance and egg quality in aged laying hens
Effects of heat stress on serum proteomics, laying performance and egg quality in aged laying hens Open
This study investigated the impact of heat stress on serum proteomics, laying performance, and egg quality in aged laying hens. Forty-eight 75-week-old Lohmann White hens were divided into two groups and subjected to either a comfort envir…
View article: Effects of heat stress on serum proteomics, laying performance and egg quality in aged laying hens
Effects of heat stress on serum proteomics, laying performance and egg quality in aged laying hens Open
This study investigated the impact of heat stress on serum proteomics, laying performance, and egg quality in aged laying hens. Forty-eight 75-week-old Lohmann White hens were divided into two groups and subjected to either a comfort envir…
View article: Extracellular Signaling Molecules from Adipose-Derived Stem Cells and Ovarian Cancer Cells Induce a Hybrid Epithelial-Mesenchymal Phenotype in a Bidirectional Interaction
Extracellular Signaling Molecules from Adipose-Derived Stem Cells and Ovarian Cancer Cells Induce a Hybrid Epithelial-Mesenchymal Phenotype in a Bidirectional Interaction Open
Ovarian cancer (OC) is characterized by high mortality rates due to late diagnosis, recurrence, and metastasis. Here, we show that extracellular signaling molecules secreted by adipose-derived mesenchymal stem cells (ASCs) and OC cells—eit…
View article: Pathophysiological mechanisms in severe preeclampsia: role of upregulated proteins in blood pressure, extracellular matrix and immunity
Pathophysiological mechanisms in severe preeclampsia: role of upregulated proteins in blood pressure, extracellular matrix and immunity Open
These findings offer valuable insights into the different pathophysiological mechanisms underlying the two subgroups of PE. The upregulated proteins in PE+ (AMBP, VTN, CLU, F2, PZP, APCS, and HBB) play key roles in regulating blood pressur…
View article: Different Proteomic Profiles Regarding Antihypertensive Therapy in Preeclampsia Pregnant
Different Proteomic Profiles Regarding Antihypertensive Therapy in Preeclampsia Pregnant Open
Preeclampsia (PE) is a hypertensive pregnancy syndrome associated with target organ damage and increased cardiovascular risks, necessitating antihypertensive therapy. However, approximately 40% of patients are nonresponsive to treatment, w…
View article: Myocardial proteome changes in aortic stenosis rats subjected to long‐term aerobic exercise
Myocardial proteome changes in aortic stenosis rats subjected to long‐term aerobic exercise Open
The effects of exercise training (ET) on the heart of aortic stenosis (AS) rats are controversial and the mechanisms involved in alterations induced by ET have been poorly clarified. In this study, we analyzed the myocardial proteome to id…
View article: Epstein-Barr Virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma
Epstein-Barr Virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma Open
The Epstein-Barr Virus (EBV) encodes viral microRNAs (miRs) that have been implicated in the pathogenesis of nasopharyngeal and gastric carcinomas, yet their potential roles in lymphomas remain to be fully elucidated. This study evaluated …
View article: Synergistic Antibacterial Efficacy of Melittin in Combination with Oxacillin against Methicillin-Resistant Staphylococcus aureus (MRSA)
Synergistic Antibacterial Efficacy of Melittin in Combination with Oxacillin against Methicillin-Resistant Staphylococcus aureus (MRSA) Open
Methicillin-resistant Staphylococcus aureus (MRSA) often cause infections with high mortality rates. Antimicrobial peptides are a source of molecules for developing antimicrobials; one such peptide is melittin, a fraction from the venom of…
View article: Preliminary Insights of Brazilian Snake Venom Metalloproteomics
Preliminary Insights of Brazilian Snake Venom Metalloproteomics Open
Snakebite envenoming is one of the most significantly neglected tropical diseases in the world. The lack of diagnosis/prognosis methods for snakebite is one of our motivations to develop innovative technological solutions for Brazilian hea…
View article: Exosome Liberation by Human Neutrophils under L-Amino Acid Oxidase of Calloselasma rhodostoma Venom Action
Exosome Liberation by Human Neutrophils under L-Amino Acid Oxidase of Calloselasma rhodostoma Venom Action Open
L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such a…
View article: Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation and proteomic profiles in Burkitt lymphoma
Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation and proteomic profiles in Burkitt lymphoma Open
The Epstein-Barr Virus (EBV) encodes viral microRNAs (miRs) that contribute to the pathogenesis of nasopharyngeal and gastric carcinomas, but their potential roles in lymphomas are still to be elucidated. This study sought to assess the im…
View article: Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation
Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation Open
The clinical manifestations of Bothrops atrox envenoming involve local and systemic changes, among which edema requires substantial attention due to its ability to progress to compartmental syndromes and sometimes cause tissue loss and amp…
View article: SEQUENCE SLIDER: integration of structural and genetic data to characterize isoforms from natural sources
SEQUENCE SLIDER: integration of structural and genetic data to characterize isoforms from natural sources Open
Proteins isolated from natural sources can be composed of a mixture of isoforms with similar physicochemical properties that coexist in the final steps of purification. Yet, even where unverified, the assumed sequence is enforced throughou…
View article: Variant expression signatures of microRNAs and protein related to growth in a crossbreed between two strains of Nile tilapia (Oreochromis niloticus)
Variant expression signatures of microRNAs and protein related to growth in a crossbreed between two strains of Nile tilapia (Oreochromis niloticus) Open
Nile tilapia (Oreochromis niloticus) is a species of worldwide importance for aquaculture. A crossbred lineage was developed through introgressive backcross breeding techniques and combines the high growth performance of the Chitralada (CH…
View article: SEQUENCE SLIDER: integration of structural and genetic data to characterize isoforms from natural source
SEQUENCE SLIDER: integration of structural and genetic data to characterize isoforms from natural source Open
Proteins isolated from natural source can be composed of a mixture of isoforms with similar physicochemical properties that coexists in final steps of purification, toxins being prominent examples. Sequence composition is enforced througho…
View article: Corona Protein Impacts on Alternating Current Biosusceptometry Signal and Circulation Times of Differently Coated Mnfe <sub>2</sub> O <sub>4</sub> Nanoparticles
Corona Protein Impacts on Alternating Current Biosusceptometry Signal and Circulation Times of Differently Coated Mnfe <sub>2</sub> O <sub>4</sub> Nanoparticles Open
Background: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-…
View article: Prospecting Biomarkers for Diagnostic and Therapeutic Approaches in Pythiosis
Prospecting Biomarkers for Diagnostic and Therapeutic Approaches in Pythiosis Open
Pythiosis, whose etiological agent is the oomycete Pythium insidiosum, is a life-threatening disease that occurs mainly in tropical and subtropical countries, affecting several animal species. It is frequently found in horses in Brazil and…
View article: Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom
Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom Open
We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee ( Apis mellifera ) Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participant…
View article: Treatment of Chronic Venous Ulcers With Heterologous Fibrin Sealant: A Phase I/II Clinical Trial
Treatment of Chronic Venous Ulcers With Heterologous Fibrin Sealant: A Phase I/II Clinical Trial Open
Background Heterologous fibrin sealant (HFS) consists of a fibrinogen-rich cryoprecipitate extracted from Bubalus bubalis buffalo blood and a thrombin-like enzyme purified from Crotalus durissus terrificus snake venom. This study evaluated…
View article: A phase I/II trial to treat massive Africanized honeybee (<i>Apis mellifera</i>) stings using the new apilic antivenom
A phase I/II trial to treat massive Africanized honeybee (<i>Apis mellifera</i>) stings using the new apilic antivenom Open
Safety, optimal minimum dose, and, preliminary effectiveness of a new generation Africanized honeybees ( Apis mellifera ) antivenom (AAV) were evaluated. A phase I/II, multicenter, non- randomized, single-arm clinical trial involving 20 pa…
View article: Chronic venous ulcers: a review on treatment with fibrin sealant and prognostic advances using proteomic strategies
Chronic venous ulcers: a review on treatment with fibrin sealant and prognostic advances using proteomic strategies Open
Venous ulcers are the main causes of chronic lower-limb ulcers. The healing difficulties encourage the research and development of new products in order to achieve better therapeutic results. Fibrin sealant is one of these alternatives. Be…
View article: Good management practices of venomous snakes in captivity to produce biological venom-based medicines: achieving replicability and contributing to pharmaceutical industry
Good management practices of venomous snakes in captivity to produce biological venom-based medicines: achieving replicability and contributing to pharmaceutical industry Open
One of the factors responsible for lack of reproducible findings may be attributed to the raw material used. To date, there are no apparent studies examining reproducibility using venoms for the development of new toxin-based drugs with re…
View article: In Situ Proteomic Analysis of Glioblastoma Multiforme: A Translational Approach to Improve Prognostic/Diagnostic Routines
In Situ Proteomic Analysis of Glioblastoma Multiforme: A Translational Approach to Improve Prognostic/Diagnostic Routines Open
In order to evaluate the use of matrix-assisted laser desorption ionization (MALDI) Mass Spectral Imaging (MSI) to Glioblastoma (GBM) studies, some sections of formalin fixed paraffin embedded samples of GBM tumors were submitted to classi…
View article: SEEKING CANDIDATE MOLECULES AS PROGNOSTIC HEALING MARKERS IN CHRONIC VENOUS ULCERS
SEEKING CANDIDATE MOLECULES AS PROGNOSTIC HEALING MARKERS IN CHRONIC VENOUS ULCERS Open
Seeking and identifying biomarker molecules in inflammatory exudate of chronic venous ulcers (CVUs) can aid health professionals in the healing prognosis. The therapeutic failure or cure is related to the quantitative expression of determi…