Lucina Q. Uddin
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View article: What we (can) know about consciousness
What we (can) know about consciousness Open
View article: Refining RDoC Using Individual-Level Task fMRI Factor Models Reveals Reproducible Brain-wide Motifs
Refining RDoC Using Individual-Level Task fMRI Factor Models Reveals Reproducible Brain-wide Motifs Open
The Research Domain Criteria (RDoC) framework was introduced to guide psychiatric research using biologically grounded, dimensional constructs of mental function. However, its current hierarchical domain structure remains largely unvalidat…
View article: Task and Resting-State Functional Magnetic Resonance Imaging Modeling of Brain-Behavior Relationships in Developmental Cohorts
Task and Resting-State Functional Magnetic Resonance Imaging Modeling of Brain-Behavior Relationships in Developmental Cohorts Open
Functional magnetic resonance imaging (fMRI) data are often used to inform individual differences in cognitive, behavioral, and psychiatric phenotypes. These so-called brain-behavior association studies come in many flavors and are increas…
View article: Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis
Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis Open
Our findings reveal a distinct transdiagnostic phenotype in EP characterized by cognitive inflexibility and arousal dysregulation that is associated with altered integration between sensory, default mode, and subcortical networks. This wor…
View article: Dynamic reconfiguration of brain coactivation states associated with active and lecture-based learning of university physics
Dynamic reconfiguration of brain coactivation states associated with active and lecture-based learning of university physics Open
Academic institutions are increasingly adopting active learning methods to enhance educational outcomes. Using functional magnetic resonance imaging (fMRI), we investigated neurobiological differences between active learning and traditiona…
View article: Global effects in fMRI reveal brain markers of state and trait anxiety
Global effects in fMRI reveal brain markers of state and trait anxiety Open
Background To personalize the diagnosis and treatment of anxiety, there is a need to identify biological constructs that underlie self-reported symptoms. Notably, physiological responses and altered levels of arousal are constituents of an…
View article: Examining recent effects of caffeine on default mode network and dorsal attention network anticorrelation in youth
Examining recent effects of caffeine on default mode network and dorsal attention network anticorrelation in youth Open
Objectives In adolescence, caffeinated beverage consumption is negatively associated with cognitive functioning. The default mode network and dorsal attention network are anticorrelated brain systems that are essentially implicated in atte…
View article: Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis
Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis Open
Background: Early psychosis (EP) is characterized by neurobiological changes, including alterations in resting-state functional connectivity (RSFC). We now understand that symptoms and neural changes may overlap across EP diagnostic catego…
View article: Convergent and Divergent Brain–Cognition Development
Convergent and Divergent Brain–Cognition Development Open
How brain networks and cognition co-evolve during development remains poorly understood. Here, we use resting-state functional magnetic resonance imaging (rs-fMRI) and cognitive data at baseline and Year 2 of 2,949 individuals in the Adole…
View article: A network correspondence toolbox for quantitative evaluation of novel neuroimaging results
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results Open
The brain can be decomposed into large-scale functional networks, but the specific spatial topographies of these networks and the names used to describe them vary across studies. Such discordance has hampered interpretation and convergence…
View article: Dynamic reconfiguration of brain coactivation states associated with active and lecture-based learning of university physics
Dynamic reconfiguration of brain coactivation states associated with active and lecture-based learning of university physics Open
Academic institutions are increasingly adopting active learning methods to enhance educational outcomes. Using functional magnetic resonance imaging (fMRI), we investigated neurobiological differences between active learning and traditiona…
View article: Introducing the Glutamate-Amplifies-Noradrenergic-Effects (GANE) Model to the Neurocognitive Study of Emotion-Related Impulsivity
Introducing the Glutamate-Amplifies-Noradrenergic-Effects (GANE) Model to the Neurocognitive Study of Emotion-Related Impulsivity Open
Emotion-related impulsivity (ERI) shows robust longitudinal associations with psychiatric disorders, aggression, and suicidality, yet a parsimonious account of its neurocognitive correlates has not been offered. We connect ERI with the glu…
View article: Age-related changes in brain signal variability in autism spectrum disorder
Age-related changes in brain signal variability in autism spectrum disorder Open
Background Brain signal variability (BSV) is an important understudied aspect of brain function linked to cognitive flexibility and adaptive behavior. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social…
View article: Dev-Atlas: A reference atlas of functional brain networks for typically developing adolescents
Dev-Atlas: A reference atlas of functional brain networks for typically developing adolescents Open
It is well accepted that the brain is functionally organized into multiple networks and extensive literature has demonstrated that the organization of these networks shows major changes during adolescence. Yet, there is limited option for …
View article: Representing Brain-Behavior Associations by Retaining High-Motion Minoritized Youth
Representing Brain-Behavior Associations by Retaining High-Motion Minoritized Youth Open
View article: A data-driven latent variable approach to validating the research domain criteria framework
A data-driven latent variable approach to validating the research domain criteria framework Open
View article: “The Brain is…”: A Survey of the Brain’s Many Definitions
“The Brain is…”: A Survey of the Brain’s Many Definitions Open
A reader of the peer-reviewed neuroscience literature will often encounter expressions like the following: ‘the brain is a dynamic system’, ‘the brain is a complex network’, or ‘the brain is a highly metabolic organ’. These expressions att…
View article: Bioethical and critical consciousness in clinical translational neuroscience
Bioethical and critical consciousness in clinical translational neuroscience Open
Clinical translational neuroscience (CTN) is positioned to generate novel discoveries for advancing treatments for mental health disorders, but it is held back today by the siloing of bioethical considerations from critical consciousness. …
View article: Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression
Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression Open
Ketamine produces fast-acting antidepressant effects in treatment-resistant depression (TRD). Prior studies have shown altered functional dynamics between brain networks in major depression. We thus sought to determine whether functional b…
View article: Multilingualism impacts children's executive function and core autism symptoms
Multilingualism impacts children's executive function and core autism symptoms Open
Autism spectrum disorder (ASD) is associated with marked heterogeneity in executive function (EF) abilities. EF components including inhibition and shifting are related to ASD core symptoms such as perspective taking, social communication,…
View article: Responsible use of population neuroscience data: Towards standards of accountability and integrity
Responsible use of population neuroscience data: Towards standards of accountability and integrity Open
This editorial focuses on the issue of data misuse which is increasingly evidenced in social media as well as some premiere scientific journals. This issue is of critical importance to open science projects in general, and ABCD in particul…
View article: Predicting Task Activation Maps from Resting-State Functional Connectivity using Deep Learning
Predicting Task Activation Maps from Resting-State Functional Connectivity using Deep Learning Open
Deep learning has been proven effective in predicting brain activation patterns from resting-state features. In this work, using resting state and task fMRI data from the Human Connectome Project (HCP), we replicate the state-of-the-art de…
View article: Responsible use of population neuroscience data: Towards standards of accountability and integrity
Responsible use of population neuroscience data: Towards standards of accountability and integrity Open
View article: Dev-Atlas: A reference atlas of functional brain networks for typically developing adolescents
Dev-Atlas: A reference atlas of functional brain networks for typically developing adolescents Open
Adolescence is a critical period for neural changes, including maturation of the brain’s cognitive networks, but also a period of increased vulnerability to psychopathology. It is well accepted that the brain is functionally organized into…
View article: Increasing the representation of minoritized youth for inclusive and reproducible brain-behavior associations
Increasing the representation of minoritized youth for inclusive and reproducible brain-behavior associations Open
Population neuroscience datasets allow researchers to estimate reliable effect sizes for brain-behavior associations because of their large sample sizes. However, these datasets undergo strict quality control to mitigate sources of noise, …
View article: A network correspondence toolbox for quantitative evaluation of novel neuroimaging results
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results Open
Decades of neuroscience research has shown that macroscale brain dynamics can be reliably decomposed into a subset of large-scale functional networks, but the specific spatial topographies of these networks and the names used to describe t…
View article: Racial Discrimination and Risk for Internalizing and Externalizing Symptoms Among Black Youths
Racial Discrimination and Risk for Internalizing and Externalizing Symptoms Among Black Youths Open
Importance Racial discrimination is a psychosocial stressor associated with youths’ risk for psychiatric symptoms. Scarce data exist on the moderating role of amygdalar activation patterns among Black youths in the US. Objective To investi…
View article: Resting state functional brain connectivity in child and adolescent psychiatry: where are we now?
Resting state functional brain connectivity in child and adolescent psychiatry: where are we now? Open
Approaching the 30th anniversary of the discovery of resting state functional magnetic resonance imaging (rsfMRI) functional connectivity, we reflect on the impact of this neuroimaging breakthrough on the field of child and adolescent psyc…
View article: Neural and psychological correlates of post-traumatic stress symptoms in a community adult sample
Neural and psychological correlates of post-traumatic stress symptoms in a community adult sample Open
A multitude of factors are associated with the symptoms of post-traumatic stress disorder. However, establishing which predictors are most strongly associated with post-traumatic stress disorder symptoms is complicated because few studies …
View article: Default mode network anti-correlation as a transdiagnostic biomarker of cognitive function
Default mode network anti-correlation as a transdiagnostic biomarker of cognitive function Open
The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, self-projection, and understanding the mindset of others. Over recent years, there has been a surge in examining…