Lucio Gnessi
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View article: SUN-675 Very Low Energy Ketogenic Therapy In Combination With Liraglutide As A Synergic Strategy For The Treatment Of Obesity: A Real-world Clinical Evaluation
SUN-675 Very Low Energy Ketogenic Therapy In Combination With Liraglutide As A Synergic Strategy For The Treatment Of Obesity: A Real-world Clinical Evaluation Open
Disclosure: E. Camajani: None. C. Camilla: None. M. Spizzichini: None. D. Masi: None. R. Rebecca: None. M. Spoltore: None. C. Lubrano: None. L. Gnessi: None. C.G. Moretti: None. M. Caprio: None. M. watanabe: None. Obesity is a complex cond…
View article: Very low‐calorie ketogenic diet and liraglutide as a synergistic strategy for the treatment of obesity: A short‐term, non‐randomised, observational, real‐world clinical evaluation
Very low‐calorie ketogenic diet and liraglutide as a synergistic strategy for the treatment of obesity: A short‐term, non‐randomised, observational, real‐world clinical evaluation Open
View article: Inositols and Bone Health: Potential Therapeutic Applications in Osteoporosis Prevention and Treatment
Inositols and Bone Health: Potential Therapeutic Applications in Osteoporosis Prevention and Treatment Open
The mechanisms underlying the disruption of bone balance are well known. To date, several possible treatments exist for osteoporosis, mostly based on inhibition of bone resorption. However, as osteoporosis is a disease that causes signific…
View article: Obesity may be more associated with disordered eating behaviors, somatization, insecure attachment styles, and sexual dysfunction: an exploratory study
Obesity may be more associated with disordered eating behaviors, somatization, insecure attachment styles, and sexual dysfunction: an exploratory study Open
Background Obesity is a challenging disease due to its multifactorial pathogenesis. However, sexual health is a poorly explored aspect in these patients, and the interaction between eating behavior, psychological factors, and sexual functi…
View article: The Chronobiology of Hormone Administration: “Doctor, What Time Should I Take My Medication?”
The Chronobiology of Hormone Administration: “Doctor, What Time Should I Take My Medication?” Open
Pharmacotherapy involving hormones and hormone-derived molecules has various potential treatment targets. This includes addressing (partial) hormonal deficiencies, pursuing osteoanabolic effects, providing contraceptive options, or support…
View article: Correction: Eating behavior patterns, metabolic parameters and circulating oxytocin levels in patients with obesity: an exploratory study
Correction: Eating behavior patterns, metabolic parameters and circulating oxytocin levels in patients with obesity: an exploratory study Open
View article: Epicardial fat thickness is increased in menopausal patients in comparison with premenopausal patients with similar excess weight: a cross-sectional study
Epicardial fat thickness is increased in menopausal patients in comparison with premenopausal patients with similar excess weight: a cross-sectional study Open
View article: Unexpected effects of treating insulin-resistant obese women with high-dose D-chiro-inositol: opening Pandora’s box
Unexpected effects of treating insulin-resistant obese women with high-dose D-chiro-inositol: opening Pandora’s box Open
Purpose The combination of lifestyle changes and nutraceuticals, such as inositols, can reduce excess weight, leading to a reduction in insulin resistance and a normalization of the metabolic profile. As such, this study investigated the m…
View article: Osteocalcin is inversely associated with worse adipose tissue distribution and cardiovascular risk in autoimmune diabetes
Osteocalcin is inversely associated with worse adipose tissue distribution and cardiovascular risk in autoimmune diabetes Open
OCN is inversely associated with unhealthy AT, supporting the protective role of OCN in AT. Moreover, lower OCN levels are associated with increased CVR in AD population.
View article: Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes
Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes Open
View article: The Impact of a Very-Low-Calorie Ketogenic Diet on Monocyte Subsets of Patients with Obesity: A Pilot Study
The Impact of a Very-Low-Calorie Ketogenic Diet on Monocyte Subsets of Patients with Obesity: A Pilot Study Open
Background/Objectives: Obesity is closely linked to chronic low-grade inflammation and the development of cardio-metabolic comorbidities. Monocyte subsets, which are crucial in immune responses, have been reported to be altered in individu…
View article: Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study
Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study Open
Aims To date, bariatric surgery (BS) is the most effective long‐term treatment for obesity, but weight regain (WR) is common. The very low‐calorie ketogenic diet (VLCKD) is effective for weight loss and may influence gut microbiota (GM) co…
View article: Reduced Intra- and Extracellular Circulating Postprandial Lysosomal Acid Lipase Activity in Patients with MASLD
Reduced Intra- and Extracellular Circulating Postprandial Lysosomal Acid Lipase Activity in Patients with MASLD Open
Background/Objectives: Low fasting blood lysosomal acid lipase (LAL) activity is associated with the pathogenesis of metabolic hepatic steatosis. We measured LAL activity in blood and plasma before and after an oral fat tolerance test (OFT…
View article: A Ketogenic Diet Followed by Gradual Carbohydrate Reintroduction Restores Menstrual Cycles in Women with Polycystic Ovary Syndrome with Oligomenorrhea Independent of Body Weight Loss: Results from a Single-Center, One-Arm, Pilot Study
A Ketogenic Diet Followed by Gradual Carbohydrate Reintroduction Restores Menstrual Cycles in Women with Polycystic Ovary Syndrome with Oligomenorrhea Independent of Body Weight Loss: Results from a Single-Center, One-Arm, Pilot Study Open
Background/Objectives: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of fertile age. Some studies suggest that a ketogenic diet (KD) may have a role in treating PCOS. We aimed to demonstrate the long-term effecti…
View article: Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex
Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex Open
Hepatic steatosis is considered the hepatic manifestation of metabolic disorders. Its global prevalence is a growing public health concern, estimated to affect over 30% of the population. Steatosis is strictly linked to metabolic dysfuncti…
View article: Bone Quality Indices Correlate with Growth Hormone Secretory Capacity in Women Affected by Weight Excess: A Cross-Sectional Study
Bone Quality Indices Correlate with Growth Hormone Secretory Capacity in Women Affected by Weight Excess: A Cross-Sectional Study Open
Background/Objectives: Obesity can be associated with impaired growth hormone (GH) secretion, with possible negative repercussions on bone health. We aimed to investigate the relationships between GH secretory capacity, evaluated with GHRH…
View article: Rethinking weight loss treatments as cardiovascular medicine in obesity, a comprehensive review
Rethinking weight loss treatments as cardiovascular medicine in obesity, a comprehensive review Open
The global escalation of obesity has made it a worldwide health concern, notably as a leading risk factor for cardiovascular disease (CVD). Extensive evidence corroborates its association with a range of cardiac complications, including co…
View article: SIRT1 Serum Concentrations in Lipodystrophic Syndromes
SIRT1 Serum Concentrations in Lipodystrophic Syndromes Open
Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokine profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone deacetylases linked to f…
View article: SIRT1 Serum Concentrations in Lipodystrophic Syndromes
SIRT1 Serum Concentrations in Lipodystrophic Syndromes Open
Lipodystrophies (LDs) are rare, complex disorders of the adipose tissue characterized by selective fat loss, altered adipokines profile and metabolic impairment. Sirtuins (SIRTs) are class III NAD+-dependent histone-deacetylases linked to …
View article: Assessing insulin resistance in obesity: An unresolved challenge
Assessing insulin resistance in obesity: An unresolved challenge Open
View article: Postbariatric surgery hypoglycemia: Nutritional, pharmacological and surgical perspectives
Postbariatric surgery hypoglycemia: Nutritional, pharmacological and surgical perspectives Open
Post‐bariatric hypoglycaemia (PBH) is a metabolic complication of bariatric surgery (BS), consisting of low post‐prandial glucose levels in patients having undergone bariatric procedures. While BS is currently the most effective and relati…
View article: Fibroblast Growth Factor 21 in Chronic Hepatitis C: A Potential Non-Invasive Biomarker of Liver Status upon Viral Eradication
Fibroblast Growth Factor 21 in Chronic Hepatitis C: A Potential Non-Invasive Biomarker of Liver Status upon Viral Eradication Open
Fibroblast growth factor 21 (FGF-21), previously recognized as a marker of liver damage and a potential drug target in non-alcoholic fatty liver disease (NAFLD), has unclear implications in hepatitis C virus (HCV) infections. This study ai…
View article: Effect on Weight Loss of an Oral Supplement Containing Cinnamon Bark (Cinnamomum cassia) and Withania somnifera in Adult Patients with Overweight and Obesity: A Pilot Study
Effect on Weight Loss of an Oral Supplement Containing Cinnamon Bark (Cinnamomum cassia) and Withania somnifera in Adult Patients with Overweight and Obesity: A Pilot Study Open
With the prevalence of obesity soaring and the absence of an effective and safe treatment that is low-cost and always feasible, food supplements have gained attention for their potential benefits in the absence of significant safety concer…
View article: The interplay between macronutrients and sleep: focus on circadian and homeostatic processes
The interplay between macronutrients and sleep: focus on circadian and homeostatic processes Open
Sleep disturbances are an emerging risk factor for metabolic diseases, for which the burden is particularly worrying worldwide. The importance of sleep for metabolic health is being increasingly recognized, and not only the amount of sleep…
View article: Weight Loss and Sleep, Current Evidence in Animal Models and Humans
Weight Loss and Sleep, Current Evidence in Animal Models and Humans Open
Sleep is a vital process essential for survival. The trend of reduction in the time dedicated to sleep has increased in industrialized countries, together with the dramatic increase in the prevalence of obesity and diabetes. Short sleep ma…
View article: Diet Plus Inositols, α-Lactalbumin and Gymnema sylvestre: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients
Diet Plus Inositols, α-Lactalbumin and Gymnema sylvestre: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients Open
The primary control of dysmetabolic patients is extremely challenging worldwide, with inadequate dietary habits and sporadic physical activity among the key risk factors for metabolic syndrome onset. Nowadays, there is no exclusive treatme…
View article: Supplementary Table 1 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity
Supplementary Table 1 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity Open
Supplementary Table 1 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for In vitro and In vivo Activity
View article: Supplementary Table 2 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity
Supplementary Table 2 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity Open
Supplementary Table 2 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for In vitro and In vivo Activity
View article: Supplementary Table 2 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity
Supplementary Table 2 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity Open
Supplementary Table 2 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for In vitro and In vivo Activity
View article: Supplementary Table 1 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity
Supplementary Table 1 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for <i>In vitro</i> and <i>In vivo</i> Activity Open
Supplementary Table 1 from Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for In vitro and In vivo Activity