Lucy R. Wedderburn
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View article: SARS-CoV-2-Specific Immune Responses to Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study
SARS-CoV-2-Specific Immune Responses to Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study Open
ISRCTN 12821688; https://www.isrctn.com/ISRCTN12821688.
View article: Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature
Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature Open
This study highlights mitochondrial dysfunction as a consistent pathological feature in JDM muscle, which may be independent of interferon-driven inflammation. These findings highlight the potential for mitochondrial-targeted therapies in …
View article: Spatially resolved fetal and maternal cell contributions to severe Preeclampsia
Spatially resolved fetal and maternal cell contributions to severe Preeclampsia Open
Summary The molecular and cellular pathophysiology of the fetal-maternal interface in preeclamsia remains poorly understood, but it is increasingly clear that both fetus and mother make independent contributions to it. Here, we spatially d…
View article: Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity
Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity Open
Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited …
View article: Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature
Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature Open
Objectives This study aimed to investigate the spatial transcriptomic landscape of muscle tissue from treatment-naïve juvenile dermatomyositis (JDM) patients in comparison to healthy paediatric muscle tissue. Methods Muscle biopsies from t…
View article: ABS0014 SPATIAL TRANSCRIPTOMIC INSIGHTS INTO INTERFERON AND MITOCHONDRIAL PATHWAY DYSREGULATION IN JUVENILE DERMATOMYOSITIS MUSCLE BIOPSIES
ABS0014 SPATIAL TRANSCRIPTOMIC INSIGHTS INTO INTERFERON AND MITOCHONDRIAL PATHWAY DYSREGULATION IN JUVENILE DERMATOMYOSITIS MUSCLE BIOPSIES Open
View article: POS1383 AUTOANTIBODIES IDENTIFIED IN MYOSITIS-SPECIFIC AUTOANTIBODY NEGATIVE JUVENILE MYOSITIS PATIENTS USING IMMUNOPRECIPITATION-MASS SPECTROMETRY
POS1383 AUTOANTIBODIES IDENTIFIED IN MYOSITIS-SPECIFIC AUTOANTIBODY NEGATIVE JUVENILE MYOSITIS PATIENTS USING IMMUNOPRECIPITATION-MASS SPECTROMETRY Open
View article: OP0252 A MULTIMODAL DISSECTION OF SPATIAL TISSUE NICHES ASSOCIATED WITH SEVERITY IN CHILDHOOD ARTHRITIS
OP0252 A MULTIMODAL DISSECTION OF SPATIAL TISSUE NICHES ASSOCIATED WITH SEVERITY IN CHILDHOOD ARTHRITIS Open
View article: TYPE I INTERFERON AND MITOCHONDRIAL DYSFUNCTION ARE ASSOCIATED WITH DYSREGULATED CYTOTOXIC CD8+ T CELL RESPONSES IN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS
TYPE I INTERFERON AND MITOCHONDRIAL DYSFUNCTION ARE ASSOCIATED WITH DYSREGULATED CYTOTOXIC CD8+ T CELL RESPONSES IN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS Open
PV001 / #50 Poster Topic: AS01 - Adaptive Immunity Background/Purpose Juvenile systemic lupus erythematosus (JSLE) is an autoimmune condition which causes significant morbidity in children and young adults. While many aspects of immune dys…
View article: Identification and validation of interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis
Identification and validation of interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis Open
In children with JIA, a high IFN-driven gene signature is associated with a better response to MTX than those with a low IFN-driven gene signature. These data could pave the way to clinically validated tools to identify those most likely t…
View article: Mortality rates in children, young people, and young adults with JIA: an observational study using the Clinical Practice Research Datalink (CPRD)
Mortality rates in children, young people, and young adults with JIA: an observational study using the Clinical Practice Research Datalink (CPRD) Open
View article: P094 Experts in lived experience: CLUSTER Champions and their successful collaboration in JIA research
P094 Experts in lived experience: CLUSTER Champions and their successful collaboration in JIA research Open
Background/Aims The CLUSTER Champions are a network of patients and parents with lived experience of juvenile idiopathic arthritis (JIA). The core aim of the Champions involvement in the CLUSTER Consortium is to create more impactful resea…
View article: Complement-mediated enhancement of SARS-CoV-2 antibody neutralisation potency in vaccinated individuals
Complement-mediated enhancement of SARS-CoV-2 antibody neutralisation potency in vaccinated individuals Open
With the continued emergence of SARS-CoV-2 variants and concerns of waning immunity, there is a need for better defined correlates of protection to aid future vaccine and therapeutic developments. Whilst neutralising antibody titres are as…
View article: Treg fitness signatures as a biomarker for disease activity in Juvenile Idiopathic Arthritis
Treg fitness signatures as a biomarker for disease activity in Juvenile Idiopathic Arthritis Open
Juvenile Idiopathic Arthritis (JIA) is an autoimmune condition characterised by flares of joint inflammation. However, no reliable biomarker exists to predict the erratic disease course. Normally, regulatory T cells (Tregs) maintain tolera…
View article: SARS-CoV-2-Specific Immune Responses to COVID-19 Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study
SARS-CoV-2-Specific Immune Responses to COVID-19 Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study Open
View article: Anti-Sp4 and anti-CCAR1 autoantibodies in UK <i>vs</i> US patients with adult and juvenile-onset anti-TIF1γ-positive myositis
Anti-Sp4 and anti-CCAR1 autoantibodies in UK <i>vs</i> US patients with adult and juvenile-onset anti-TIF1γ-positive myositis Open
Objectives Anti-transcriptional intermediary factor 1γ (TIF1γ) autoantibodies are associated with malignancy in adult-onset idiopathic inflammatory myopathy (IIM) and this risk is attenuated if patients are also positive for anti-specifici…
View article: The immune landscape of the inflamed joint defined by spectral flow cytometry
The immune landscape of the inflamed joint defined by spectral flow cytometry Open
Cellular phenotype and function are altered in different microenvironments. For targeted therapies it is important to understand site-specific cellular adaptations. Juvenile idiopathic arthritis (JIA) is characterized by autoimmune joint i…
View article: Discovery of new myositis genetic associations through leveraging other immune-mediated diseases
Discovery of new myositis genetic associations through leveraging other immune-mediated diseases Open
View article: Oestrogen influences B cell class-switching in individuals with an XX sex chromosome complement
Oestrogen influences B cell class-switching in individuals with an XX sex chromosome complement Open
Sex differences in humoral immunity are well-documented, though the mechanisms underpinning these differences remain ill-defined. Here, we demonstrate that post-pubertal cisgender females have higher levels of class-switched B cells compar…
View article: Treg fitness as a biomarker for disease activity in Juvenile Idiopathic Arthritis
Treg fitness as a biomarker for disease activity in Juvenile Idiopathic Arthritis Open
Juvenile Idiopathic Arthritis (JIA) is an autoimmune condition characterised by persistent flares of joint inflammation. However, no reliable biomarker exists to predict the erratic disease course. Normally, regulatory T cells (Tregs) main…
View article: E014 Migration of the large complex dataset of the UK Juvenile Dermatomyositis Cohort Biomarker Study: challenges and lessons
E014 Migration of the large complex dataset of the UK Juvenile Dermatomyositis Cohort Biomarker Study: challenges and lessons Open
Background/Aims In rare disease research, longitudinal prospective cohort studies are important tools to generate invaluable real-world evidence to inform treatment choices and understand outcomes. The Juvenile Dermatomyositis Cohort Bioma…
View article: P096 Pathway directionality across different immune cell lineages contributes to methotrexate response in juvenile idiopathic arthritis
P096 Pathway directionality across different immune cell lineages contributes to methotrexate response in juvenile idiopathic arthritis Open
Background/Aims Juvenile idiopathic arthritis (JIA) is the most common autoimmune rheumatic disease in children with methotrexate (MTX) as the first line treatment. However, about 50% of JIA patients will not respond well to MTX yet still …
View article: Correction to: Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis: results from the MYONET registry
Correction to: Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis: results from the MYONET registry Open
View article: Designing, Developing, and Testing a Chatbot for Parents and Caregivers of Children and Young People With Rheumatological Conditions (the IMPACT Study): Protocol for a Co-Designed Proof-of-Concept Study
Designing, Developing, and Testing a Chatbot for Parents and Caregivers of Children and Young People With Rheumatological Conditions (the IMPACT Study): Protocol for a Co-Designed Proof-of-Concept Study Open
Background Pediatric rheumatology is a term that encompasses over 80 conditions affecting different organs and systems. Children and young people with rheumatological chronic conditions are known to have high levels of mental health proble…
View article: Designing, Developing, and Testing a Chatbot for Parents and Caregivers of Children and Young People With Rheumatological Conditions (the IMPACT Study): Protocol for a Co-Designed Proof-of-Concept Study (Preprint)
Designing, Developing, and Testing a Chatbot for Parents and Caregivers of Children and Young People With Rheumatological Conditions (the IMPACT Study): Protocol for a Co-Designed Proof-of-Concept Study (Preprint) Open
BACKGROUND Pediatric rheumatology is a term that encompasses over 80 conditions affecting different organs and systems. Children and young people with rheumatological chronic conditions are known to have high levels of mental health probl…
View article: Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts
Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts Open
Medical Research Council, Versus Arthritis, Great Ormond Street Hospital Children's Charity, Olivia's Vision, and the National Institute for Health Research.
View article: The immune landscape of the inflamed joint defined by spectral flow cytometry
The immune landscape of the inflamed joint defined by spectral flow cytometry Open
Cellular phenotype and function are altered in different microenvironments. For targeted therapies it is important to understand site-specific cellular adaptations. Juvenile Idiopathic Arthritis (JIA) is characterised by joint inflammation…
View article: Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods
Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods Open
Gene expression studies often use bulk RNA sequencing of mixed cell populations because single cell or sorted cell sequencing may be prohibitively expensive. However, mixed cell studies may miss expression patterns that are restricted to s…
View article: Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes Open
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has been implicated in inflammatory conditions, but large-scale metagenomic evaluations have not yet traced the routes by which immunity in the gut affects i…
View article: POS0753 TIF1-GAMMA IGG2 ISOTYPE IS ASSOCIATED WITH ETHNICITY IN JDM PATIENTS
POS0753 TIF1-GAMMA IGG2 ISOTYPE IS ASSOCIATED WITH ETHNICITY IN JDM PATIENTS Open