Explanipedia

Alterations in chromatin accessibility and conformation elucidate genetic mechanisms in ASD Open

Jiani Yin, Jerry I. Huang, Jing Ou, George Chen, Lucy Bicks , et al. · 2025

Genetic risk for psychiatric disorders lies largely within non-coding regions, where the lack of detailed knowledge of gene regulation and chromatin structure has hampered understanding of disease mechanisms. We analyzed chromatin accessib…

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders Open

Andrew D. Grotzinger, Josefin Werme, Wouter J. Peyrot, Oleksandr Frei, Christiaan A. de Leeuw , et al. · 2025

Psychiatric disorders display high levels of comorbidity and genetic overlap 1,2 . Genomic methods have shown that even for schizophrenia and bipolar disorder, two disorders long-thought to be etiologically distinct 3 , the majority of gen…

A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex Open

Louise A. Huuki-Myers, Abby Spangler, Nicholas J. Eagles, Kelsey D. Montgomery, Sang Ho Kwon , et al. · 2024

The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally defi…

Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain Open

Cindy Wen, Michael Margolis, Rujia Dai, Pan Zhang, Pawel F. Przytycki , et al. · 2024

Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain. However, prioritizing risk genes and mechanis…

Single-cell genomics and regulatory networks for 388 human brains Open

Prashant S. Emani, Jason Liu, Declan Clarke, Matthew Jensen, Jonathan Warrell , et al. · 2024

Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, …

Massively parallel characterization of regulatory elements in the developing human cortex Open

Chengyu Deng, Sean Whalen, Marilyn Steyert, Ryan Ziffra, Pawel F. Przytycki , et al. · 2024

Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogat…

Developmental convergence and divergence in human stem cell models of autism spectrum disorder Open

Aaron Gordon, Se‐Jin Yoon, Lucy Bicks, Jacqueline M. Martín, Greta Pintacuda , et al. · 2024

Two decades of genetic studies in autism spectrum disorder (ASD) have identified over a hundred genes harboring rare risk mutations. Despite this substantial heterogeneity, transcriptomic and epigenetic analyses have identified convergent …

Single-cell genomics and regulatory networks for 388 human brains Open

Prashant S. Emani, Jason J. Liu, Declan Clarke, Matthew L. Jensen, Jonathan Warrell , et al. · 2024

Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet, little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei,…

The contributions of rare inherited and polygenic risk to ASD in multiplex families Open

Matilde Cirnigliaro, Timothy S. Chang, Stephanie A. Arteaga, Laura Pérez‐Cano, Elizabeth K. Ruzzo , et al. · 2023

Autism spectrum disorder (ASD) has a complex genetic architecture involving contributions from both de novo and inherited variation. Few studies have been designed to address the role of rare inherited variation or its interaction with com…

Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics Open

Brie Wamsley, Lucy Bicks, Yuyan Cheng, Riki Kawaguchi, Diana Quintero , et al. · 2023

Understanding how genetic variation exerts its effects on the human brain in health and disease has been greatly informed by functional genomic characterization. Studies over the last decade have demonstrated robust evidence of convergent …

Neuronal protein interaction networks in autism spectrum disorder Open

Lucy Bicks, Katherine W. Eyring, Daniel H. Geschwind · 2023

How rare protein-disrupting risk variants implicated in autism spectrum disorders (ASDs) interact or functionally converge is unknown. Pintacuda et al.¹ perform proteomics in induced human neurons and identify more than 1,000 in…

The Contributions of Rare Inherited and Polygenic Risk to ASD in Multiplex Families Open

Timothy S. Chang, Matilde Cirnigliaro, Stephanie A. Arteaga, Laura Pérez‐Cano, Elizabeth K. Ruzzo , et al. · 2022

Autism Spectrum Disorder (ASD) has a complex genetic architecture involving contributions from de novo and inherited variation. Few studies have been designed to address the role of rare inherited variation, or its interaction with polygen…

Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions Open

Sandhya Chandrasekaran, Sergio Espeso‐Gil, Yong‐Hwee Eddie Loh, Behnam Javidfar, Bibi Kassim , et al. · 2021

NEURON-SPECIFIC CHROMOSOMAL MEGADOMAIN ORGANIZATION IS ADAPTIVE TO RECENT RETROTRANSPOSON EXPANSIONS Open

Sandhya Chandrasekaran, Sergio Espeso‐Gil, Yong‐Hwee Eddie Loh, Behnam Javidfar, Bibi Kassim , et al. · 2021

Here, we mapped cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic ‘B 2 NeuN+ ’ megabase-sc…

An Adolescent Sensitive Period for Social Dominance Hierarchy Plasticity Is Regulated by Cortical Plasticity Modulators in Mice Open

Lucy Bicks, Michelle S. Peng, Alana Taub, Schahram Akbarian, Hirofumi Morishita · 2021

Social dominance hierarchies are a common adaptation to group living and exist across a broad range of the animal kingdom. Social dominance is known to rely on the prefrontal cortex (PFC), a brain region that shows a protracted development…

A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice Open

Kazuhiko Yamamuro, Lucy Bicks, Michael B. Leventhal, Daisuke Kato, Susanna Im , et al. · 2020

S189. PREFRONTAL PARVALBUMIN INTERNEURONS REQUIRE JUVENILE SOCIAL EXPERIENCE TO ESTABLISH ADULT SOCIAL BEHAVIOR Open

Lucy Bicks, Kazuhiko Yamamuro, Meghan E. Flanigan, Elizabeth K. Lucas, Hiroyuki Koike , et al. · 2020

Background Social isolation during developmental critical windows could be highly detrimental to proper functioning of mature prefrontal cortex (PFC) and establishment of appropriate adult behaviors. However, the specific circuits that und…

Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior Open

Lucy Bicks, Kazuhiko Yamamuro, Meghan E. Flanigan, Julia Minjung Kim, Daisuke Kato , et al. · 2020

Acknowledgments Open

Leonard Abbeduto, Chris Abbott, Jessica L. Ables, Ashley Acheson, Giovanni Addolorato , et al. · 2018

Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility Open

Mitra Heshmati, Hossein Aleyasin, Caroline Ménard, Daniel J. Christoffel, Meghan E. Flanigan , et al. · 2018

Significance Although mutations in the neuroligin-3 and neuroligin-4 genes are implicated in autism syndromes, very little is known about the contribution of neuroligin-2 to neuropsychiatric disease states. We report a decrease in neurolig…

The epigenomics of schizophrenia, in the mouse Open

Behnam Javidfar, Royce Park, Bibi Kassim, Lucy Bicks, Schahram Akbarian · 2017

Large‐scale consortia including the Psychiatric Genomics Consortium, the Common Minds Consortium, BrainSeq and PsychENCODE, and many other studies taken together provide increasingly detailed insights into the genetic and epigenetic risk a…

MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice Open

Amanda Mitchell, Behnam Javidfar, Venu Pothula, Daisuke Ibi, Erica Shen , et al. · 2017

Acknowledgment of Ad Hoc Reviewers Open

Anders Ågmo, Bruno B. Averbeck, Elena Azañón, Stephanie Badde, Karen L. Bales , et al. · 2017

Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex Open

Amanda Mitchell, Behnam Javidfar, Lucy Bicks, Rachael L. Neve, Krassimira Garbett , et al. · 2016

Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex Open

Amanda Mitchell, Behnam Javidfar, Lucy Bicks, Krassimira Garbett, Sharon S Lander , et al. · 2016

Neuronal epigenomes, including chromosomal loopings moving distal cis-regulatory elements into proximity of target genes, could serve as molecular proxy linking present-day-behaviour to past exposures. However, longitudinal assessment of c…

Social functioning in major depressive disorder Open

Aleksandra Kupferberg, Lucy Bicks, Gregor Hasler · 2016

Depression is associated with social risk factors, social impairments and poor social functioning. This paper gives an overview of these social aspects using the NIMH Research and Domain Criteria 'Systems for Social Processes' as a framewo…

Prefrontal Cortex and Social Cognition in Mouse and Man Open

Lucy Bicks, Hiroyuki Koike, Schahram Akbarian, Hirofumi Morishita · 2015

Social cognition is a complex process that requires the integration of a wide variety of behaviors, including salience, reward-seeking, motivation, knowledge of self and others, and flexibly adjusting behavior in social groups. Not surpris…

Sex, social status, and CRF receptor densities in naked mole‐rats Open

Annaliese K. Beery, Lucy Bicks, Skyler J. Mooney, Nastacia L. Goodwin, Melissa M. Holmes · 2015

Naked mole‐rats ( Heterocephalus glaber ) live in groups that are notable for their large size and caste structure, with breeding monopolized by a single female and a small number of males. Recent studies have demonstrated substantial diff…

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