Xing Liu
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View article: Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress
Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress Open
Acute stressors, significant risk factors for mood disorders, increase anxiety and reduce reward sensitivity. However, the underlying neuroadaptive mechanisms remain unclear. Here, it is shown that acute restraint stress upregulates Signal…
View article: The intrinsic excitability of and autophagy protein expression levels in dentate gyrus ensembles regulate fear generalization
The intrinsic excitability of and autophagy protein expression levels in dentate gyrus ensembles regulate fear generalization Open
The overgeneralization of fear is associated with psychiatric disorders and cognitive decline. Recent studies have shown that engram cells in the dorsal dentate gyrus are integrated into functionally heterogeneous ensembles that are involv…
View article: Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease Open
Background Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic fat accumulation and is closely associated with obesity, diabetes, and hyperlipidemia. Objectives This study explores the effects of pachymaran on NA…
View article: Advances in irreversible electroporation for prostate cancer
Advances in irreversible electroporation for prostate cancer Open
Irreversible electroporation is a nonthermal ablation technique that uses a high-voltage electric current to create nanosized pores in the cell membrane of a malignant tumor, thus resulting in cell death. In recent years, an increasing num…
View article: <scp>T2T</scp> genomes of carrot and <i>Alternaria dauci</i> and their utility for understanding host–pathogen interactions during carrot leaf blight disease
<span>T2T</span> genomes of carrot and <i>Alternaria dauci</i> and their utility for understanding host–pathogen interactions during carrot leaf blight disease Open
SUMMARY Carrot ( Daucus carota ) is one of the most popular and nutritious vegetable crops worldwide. However, significant yield losses occur every year due to leaf blight, a disease caused by a fungal pathogen ( Alternaria dauci ). Past r…
View article: Inflammation-oriented montmorillonite adjuvant enhanced oral delivery of anti-TNF-α nanobody against inflammatory bowel disease
Inflammation-oriented montmorillonite adjuvant enhanced oral delivery of anti-TNF-α nanobody against inflammatory bowel disease Open
Oral delivery of proteins faces challenges due to the harsh conditions of the gastrointestinal (GI) tract, including gastric acid and intestinal enzyme degradation. Permeation enhancers are limited in their ability to deliver proteins with…
View article: Destabilization of fear memory by Rac1-driven engram-microglia communication in hippocampus
Destabilization of fear memory by Rac1-driven engram-microglia communication in hippocampus Open
Rac1 is a key regulator of the cytoskeleton and neuronal plasticity, and is known to play a critical role in psychological and cognitive brain disorders. To elucidate the engram specific Rac1 signaling in fear memory, a doxycycline (Dox)-d…
View article: Abstract 1392 Identification of CAND1 and CAND2 interacting proteins using BioID
Abstract 1392 Identification of CAND1 and CAND2 interacting proteins using BioID Open
Cullin-associated Nedd8-dissociated 1 and 2 (CAND1 and CAND2) are key regulators of cullin-RING ubiquitin ligases (CRLs). CRLs are composed of a cullin scaffold, a RING protein, a substrate receptor, and adaptor proteins. They catalyze the…
View article: Safety, tolerability, pharmacokinetics and neutrophil elastase inhibitory effects of Sivelestat: A randomized, double-blind, placebo-controlled single- and multiple-dose escalation study in Chinese healthy subjects
Safety, tolerability, pharmacokinetics and neutrophil elastase inhibitory effects of Sivelestat: A randomized, double-blind, placebo-controlled single- and multiple-dose escalation study in Chinese healthy subjects Open
www.chinadrugtrials.org.cn identifier is CTR20210072.
View article: Combination therapy of anti-TNF nanobody and PGE2 elevated therapeutic effect in experimental colits via regulating Treg/Th17 balance
Combination therapy of anti-TNF nanobody and PGE2 elevated therapeutic effect in experimental colits via regulating Treg/Th17 balance Open
Backgrounds and purpose: Anti-TNF therapy have gained great success in autoimmune disease. However, insufficient efficacy and safety of high dosage anti-TNF agents are exposed in amounts of clinical cases. Aiming at improving therapeutic o…
View article: A novel combined technology for treating hypertrophic scars: adipose tissue extract combined with fractional CO2 laser
A novel combined technology for treating hypertrophic scars: adipose tissue extract combined with fractional CO2 laser Open
Introduction: Owing to the need for liposuction and its unsuitability for allogeneic transplantation, the clinical application of stromal vascular fraction gel (SVF-gel) combined with fractional CO 2 laser for scar treatment is limited. Ad…
View article: Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors
Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors Open
Cooperativity and antagonism between transcription factors (TFs) can drastically modify their binding to regulatory DNA elements. While mapping these relationships between TFs is important for understanding their context-specific functions…
View article: CDDO-Me ameliorates podocyte injury through anti-oxidative stress and regulation of actin cytoskeleton in adriamycin nephropathy
CDDO-Me ameliorates podocyte injury through anti-oxidative stress and regulation of actin cytoskeleton in adriamycin nephropathy Open
Podocyte injury is the common initiating event in focal segmental glomerulosclerosis (FSGS). Oxidative stress and inflammation mediate podocyte injury in FSGS. NRF2 pathway regulates the constitutive and inducible transcription of various …
View article: Proteomic sequencing analysis in a rat model of atrial fibrosis caused by chronic intermittent hypoxia
Proteomic sequencing analysis in a rat model of atrial fibrosis caused by chronic intermittent hypoxia Open
Myh7, Myl2, Myl3, and Atpla3 may play key roles in the progression of atrial fibrillation through their involvement in cardiovascular-disease-related signaling pathways.
View article: Machine Learning-Based Prediction Models for Parathyroid Carcinoma Using Pre- Surgery Cognitive Function and Clinical Features
Machine Learning-Based Prediction Models for Parathyroid Carcinoma Using Pre- Surgery Cognitive Function and Clinical Features Open
Background Patients with parathyroid carcinoma (PC) are often diagnosed postoperatively, due to incomplete resection during the initial surgery, resulting in poor outcomes. The aim of our study was to investigate the pre-surgery indicators…
View article: Comparative evaluation of costs and healthcare resource utilization of oral selexipag versus inhaled treprostinil or oral treprostinil in patients with pulmonary arterial hypertension
Comparative evaluation of costs and healthcare resource utilization of oral selexipag versus inhaled treprostinil or oral treprostinil in patients with pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH), a rare vasculopathy progressively leading to right heart failure and death, is associated with considerable economic burden. Oral prostacyclin pathway agents (PPAs) like selexipag and treprostinil add…
View article: Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors
Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors Open
Cooperativity and antagonism between transcription factors (TFs) can drastically modify their binding to regulatory DNA elements. While mapping these relationships between TFs is important for understanding their context-specific functions…
View article: Impact of initial limited fluid resuscitation in sepsis patients
Impact of initial limited fluid resuscitation in sepsis patients Open
Review question / Objective: To Evaluate the impact of different fluid resuscitation strategies in sepsis.Condition being studied: Intravenous fluid resuscitation is a common therapy used in the initial treatment of patients with septic sh…
View article: Data from Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma
Data from Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma Open
Prospective data are limited regarding dynamic adulthood weight changes and hepatocellular carcinoma (HCC) risk. We included 77,238 women (1980–2012) and 48,026 men (1986–2012), who recalled young-adult weight [age 18 years (women); 21 yea…
View article: Supplementary Data from Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma
Supplementary Data from Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma Open
Supplementary Methods Supplementary Tables Table S1. Age-standardized Characteristics of Participants from NHS (n=56,224) and HPFS (n=35,975) With Available Waist Circumference Data in 1986 (NHS) and 1987 (HPFS), According to Adulthood Wei…
View article: Supplementary Data from Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma
Supplementary Data from Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma Open
Supplementary Methods Supplementary Tables Table S1. Age-standardized Characteristics of Participants from NHS (n=56,224) and HPFS (n=35,975) With Available Waist Circumference Data in 1986 (NHS) and 1987 (HPFS), According to Adulthood Wei…
View article: Figure S7 from The Landscape of Viral Expression Reveals Clinically Relevant Viruses with Potential Capability of Promoting Malignancy in Lower-Grade Glioma
Figure S7 from The Landscape of Viral Expression Reveals Clinically Relevant Viruses with Potential Capability of Promoting Malignancy in Lower-Grade Glioma Open
Cytomegalovirus infection in glioma (A) and survival analysis (B)
View article: Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma, and chronic liver disease mortality
Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma, and chronic liver disease mortality Open
Background Diet modulates inflammation and insulin response and may be an important modifiable factor in the primary prevention of hepatocellular carcinoma (HCC) and chronic liver disease (CLD). We developed the empirical dietary inflammat…