Li Hua
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View article: Prenatal Exposure to Perfluorooctanoic Acid and Childhood Allergic Diseases: A Prospective Birth Cohort Study
Prenatal Exposure to Perfluorooctanoic Acid and Childhood Allergic Diseases: A Prospective Birth Cohort Study Open
Background Perfluorooctanoic acid (PFOA) is widely used in daily life; however, research has shown its immune suppression effects. This study aimed to investigate the association between prenatal exposure to PFOA and allergic diseases in c…
View article: High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex
High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex Open
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric diso…
View article: Soil Organic Carbon Dynamics in Northeast China Under Water Erosion: Spatiotemporal Patterns and Driving Mechanisms
Soil Organic Carbon Dynamics in Northeast China Under Water Erosion: Spatiotemporal Patterns and Driving Mechanisms Open
View article: Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus
Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus Open
View article: Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus
Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus Open
Background Previously, we reported that serum Semaphorin 5A (Sema5A) levels were increased in systemic lupus erythematosus (SLE) patients compared with healthy controls (HC), and elevated Sema5A correlated with disease activity and lupus n…
View article: The role of the natural compound naringenin in AMPK-mitochondria modulation and colorectal cancer inhibition
The role of the natural compound naringenin in AMPK-mitochondria modulation and colorectal cancer inhibition Open
Our data suggest that naringenin is important for inhibiting CRC proliferation, possibly through the AMPK pathway, to regulate mitochondrial function and induce apoptosis in CRC.
View article: RIPK4 Promotes Cell Invasion and the Epithelial–Mesenchymal Transition in Ovarian Cancer
RIPK4 Promotes Cell Invasion and the Epithelial–Mesenchymal Transition in Ovarian Cancer Open
Objective: To investigate the clinical role and biological function of receptor-interacting protein kinase 4 (RIPK4) in ovarian cancer (OC). Methods: We conducted a comprehensive analysis of the expression and prognostic role of RIPK4 in O…
View article: The analysis of risk factors for recurrent wheezing in infants and clinical intervention
The analysis of risk factors for recurrent wheezing in infants and clinical intervention Open
BACKGROUND: Asthma is one of the most common chronic diseases affecting children’s health, and recurrent wheezing in infants is closely related to childhood asthma. However, up to now, there is a lack of unified diagnostic criteria and int…
View article: The efficacy and safety of patent Foramen Ovale Closure for Refractory Epilepsy (PFOC-RE): a prospectively randomized control trial of an innovative surgical therapy for refractory epilepsy patients with PFO of high-grade right-to-left shunt
The efficacy and safety of patent Foramen Ovale Closure for Refractory Epilepsy (PFOC-RE): a prospectively randomized control trial of an innovative surgical therapy for refractory epilepsy patients with PFO of high-grade right-to-left shunt Open
Background A significant proportion of patients with epilepsy have an unknown etiology and lack effective targeted therapeutic drugs. Patent Foramen Ovale (PFO) induces hypoxia and microembolism, leading to cerebral neurological dysfunctio…
View article: Supplementary Figure 7 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice
Supplementary Figure 7 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice Open
PDF file - 116K, In vivo response of xenograftted tumors.
View article: Data from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice
Data from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice Open
Purpose: High-throughput chemosensitivity testing of low-passage cancer cell lines can be used to prioritize agents for personalized chemotherapy. However, generating cell lines from primary cancers is difficult because contaminatin…
View article: Supplementary Figure 7 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice
Supplementary Figure 7 from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice Open
PDF file - 116K, In vivo response of xenograftted tumors.
View article: Data from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice
Data from Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice Open
Purpose: High-throughput chemosensitivity testing of low-passage cancer cell lines can be used to prioritize agents for personalized chemotherapy. However, generating cell lines from primary cancers is difficult because contaminatin…
View article: Human activities have been a key driver of hydraulic erosion changes in northeastern China over the past 37 years
Human activities have been a key driver of hydraulic erosion changes in northeastern China over the past 37 years Open
Northeast China is experiencing severe soil erosion, resulting in land degradation and nutrient loss. Among them, hydraulic erosion poses the greatest threat to food security. Combining various multi-source data, we applied the modified so…
View article: Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis Open
Neutrophils, the most abundant innate immune cells, function as crucial regulators of the adaptive immune system in diverse pathological conditions, including metastatic cancer. However, it remains largely unknown whether their immunomodul…
View article: APOA1 mRNA and protein in kidney renal clear cell carcinoma correlate with the disease outcome
APOA1 mRNA and protein in kidney renal clear cell carcinoma correlate with the disease outcome Open
Renal cancer is one of the most common malignant tumors with high mortality, and kidney renal clear cell carcinoma (KIRC) is the most common type of renal cancer. We attempted to evaluate the clinical and prognostic significance of Apolipo…
View article: Contents
Contents Open
Two-level consensus modeling with utility and
View article: Correlation of ICU Nurses’ Cognitive Level with Their Attitude and Behavior toward the Prevention of Ventilator-Associated Pneumonia
Correlation of ICU Nurses’ Cognitive Level with Their Attitude and Behavior toward the Prevention of Ventilator-Associated Pneumonia Open
Objective. To analyze the correlation of ICU nurses’ cognitive level with their attitude and behavior toward the prevention of ventilator-associated pneumonia (VAP). Methods. A total of 90 ICU nurses working in the adult internal medicine …
View article: Effective treatment of pulmonary adenocarcinoma harboring triple EGFR mutations of L858R, T790M, cis-G796s/cis-C797s by osimertinib, brigatinib, and bevacizumab combination therapy: A case report
Effective treatment of pulmonary adenocarcinoma harboring triple EGFR mutations of L858R, T790M, cis-G796s/cis-C797s by osimertinib, brigatinib, and bevacizumab combination therapy: A case report Open
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) were widely used in advanced non-small cell lung cancers (NSCLCs) with EGFR sensitive mutation and greatly improved the patient survival. With the widespread use of EG…
View article: A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials
A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials Open
Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-c…
View article: Interleukin‐6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model
Interleukin‐6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model Open
Background T helper 17 (Th17) cells actively participate in the tumor immune response in lung cancer. However, the heterogeneity and plasticity of intratumoral Th17 cells in lung cancer remain elusive. In this study, Th17 subpopulations we…
View article: Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis Open
View article: Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status Open
View article: A pilot study to evaluate the role of peripheral blood CD4+CRTh2+CCR6+ in predicting future asthma in preschool wheezing children: Outcome of two-year follow-up
A pilot study to evaluate the role of peripheral blood CD4+CRTh2+CCR6+ in predicting future asthma in preschool wheezing children: Outcome of two-year follow-up Open
Background：Wheezing is an important respiratory symptom in the diagnosis of asthma. However, wheezing is common in children and often related to viral infection. This and the lack of reliable biological indicators for asthma create difficu…
View article: <p>Long Non-Coding RNA DUXAP8 Facilitates Cell Viability, Migration, and Glycolysis in Non-Small-Cell Lung Cancer via Regulating HK2 and LDHA by Inhibition of miR-409-3p</p>
Long Non-Coding RNA DUXAP8 Facilitates Cell Viability, Migration, and Glycolysis in Non-Small-Cell Lung Cancer via Regulating HK2 and LDHA by Inhibition of miR-409-3p Open
Our findings demonstrated that DUXAP8 served as an oncogene in the progression of NSCLC.
View article: Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer: a study from Guangxi Zhuang
Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer: a study from Guangxi Zhuang Open
Background There are obviously ethnic differences between the UGT1A1 gene polymorphisms. Due to the difference of genetic background and environment, the treatment with colorectal cancer patients of Guangxi Zhuang should not completely fol…
View article: MicroRNA-145 suppresses epithelial to mesenchymal transition in pancreatic cancer cells by inhibiting TGF-β signaling pathway
MicroRNA-145 suppresses epithelial to mesenchymal transition in pancreatic cancer cells by inhibiting TGF-β signaling pathway Open
TGF-β signaling plays a critical role in tumor progression and many approaches have been made to inhibit its functions. MicroRNA is one of the approaches that inhibit TGF-β signaling and can be used as a promising treatment for cancer. Thi…
View article: Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)
Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review) Open
A variety of cells and cytokines have been shown to be involved in the whole process of hypertension. Data from experimental and clinical studies on hypertension have confirmed the key roles of immune cells and inflammation in the process.…
View article: Thermodynamic of β-cyclodextrin in sucrose solution
Thermodynamic of β-cyclodextrin in sucrose solution Open
View article: Molecular dynamics simulations of surface effects on Couette gas flows in nanochannels
Molecular dynamics simulations of surface effects on Couette gas flows in nanochannels Open
Molecular dynamics method is used to investigate gas flows in nanoscale channels. A set of Couette gas flows with the same Knudsen number but different channel heights and densities is simulated to study the dimensional effects on dynamica…