Lucy Marsh
YOU?
Author Swipe
Treatment Intensification With Either Fludarabine, AraC, G-CSF and Idarubicin, or Cladribine Plus Daunorubicin and AraC on the Basis of Residual Disease Status in Older Patients With AML: Results From the NCRI AML18 Trial Open
PURPOSE To evaluate the survival benefit of chemotherapy intensification in older patients with AML who have not achieved a measurable residual disease (MRD)–negative remission. METHODS Five hundred twenty-three patients with AML (median a…
Gemtuzumab Based Induction Chemotherapy Combined with Midostaurin for FLT3 Mutated Patients. Results from the Patient- Reported Outcome Measures from the NCRI AML19V2 ‘Midotarg Pilot‘ Open
Introduction: The AML19 v2 ‘midotarg’ pilot explored the safety and efficacy of Midostaurin in patients with a FLT3 mutation who had received DA chemotherapy combined with one or two doses of Gemtuzumab Ozogamicin (GO) in induction. The ad…
Optimising Therapy in <i>FLT3</i>-Mutated Acute Myeloid Leukaemia Open
Background Substantial progress has been made in the treatment of Acute myeloid leukaemia (AML) with changes to chemotherapy schedules and the addition of novel targeted therapies(Burnett et al. Br J Haematol 2020;188:86-100). Recently app…
Healthcare consumer acceptability of routine use of the EQ-5D-5L in clinical care: a cross-sectional survey Open
Purpose Patient reported outcome measures, such as the EQ-5D-5L, provide a measure of self-perceived health status or health-related quality of life. Understanding the consumer acceptability of a patient reported outcome measure can help t…
Mapping the use of patient reported outcomes at a health organisation to inform integration into hospital data systems. Open
ObjectivesIncorporating patient reported outcomes into health data linkage research ensures that the patient’s perspective is considered. We aimed to understand the use of patient reported outcomes across an entire healthcare organisation,…
What is the purpose of Clinical Trial Monitoring? Open
Background The sources of information on clinical trial monitoring do not give information in an accessible language and do not give detailed guidance. In order to enable communication and to build clinical trial monitoring tools on a stro…
Evaluation of the acceptability of patient-reported outcome measures in women following pelvic floor procedures Open
Purpose. Patient-reported outcome measures (PROMs) are valuable tools in evaluating the outcomes of surgical treatment health-related quality of life (HRQoL) of women with stress urinary incontinence (SUI), and may be incorporated into rel…
Efficacy and acceptability of pharmacological and non-pharmacological interventions for non-specific chronic low back pain: a protocol for a systematic review and network meta-analysis Open
Background Despite the enormous financial and humanistic burden of chronic low back pain (CLBP), there is little consensus on what constitutes the best treatment options from a multitude of competing interventions. The objective of this ne…
View article: PRImary care Management of lower Urinary tract Symptoms in men: protocol for development and validation of a diagnostic and clinical decision support tool (the PriMUS study)
PRImary care Management of lower Urinary tract Symptoms in men: protocol for development and validation of a diagnostic and clinical decision support tool (the PriMUS study) Open
Introduction Lower urinary tract symptoms (LUTS) is a bothersome condition affecting older men which can lead to poor quality of life. General practitioners (GPs) currently have no easily available assessment tools to help effectively diag…
View article: Physical Activity and Exercise Outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month Trial Within Cohort Evaluation of a Physical Activity Intervention in People With Huntington Disease
Physical Activity and Exercise Outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month Trial Within Cohort Evaluation of a Physical Activity Intervention in People With Huntington Disease Open
Background Exercise is emerging as an important aspect in the management of disease-related symptoms and functional decline in people with Huntington disease (HD). Long-term evaluation of physical activity and exercise participation in HD …
Enterococcus faecalis Demonstrates Pathogenicity through Increased Attachment in an<i>Ex Vivo</i>Polymicrobial Pulpal Infection Open
This study investigated the host response to a polymicrobial pulpal infection consisting of Streptococcus anginosus and Enterococcus faecalis , bacteria commonly implicated in dental abscesses and endodontic failure, using a validated ex v…