Nick D. Jones
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View article: Differential control of mycobacteria among COVID-19 patients is associated with CD28+ CD8+ T cells
Differential control of mycobacteria among COVID-19 patients is associated with CD28+ CD8+ T cells Open
Diseases caused by SARS-CoV-2 and Mycobacterium tuberculosis ( M.tb ) represent two public health emergencies. In severe disease, both pathogens may share a biological niche in the lower respiratory tract. There is significant potential fo…
View article: Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma
Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma Open
Systemic treatment for advanced hepatocellular carcinoma (HCC) has been revolutionized over the last few years following the approval of immune checkpoint inhibitors (ICI). Despite the promising survival extension seen with ICI combination…
View article: Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses
Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses Open
Introduction Vaccination with Vi capsular polysaccharide (Vi-PS) or protein-Vi typhoid conjugate vaccine (TCV) can protect adults against Salmonella Typhi infections. TCVs offer better protection than Vi-PS in infants and may offer better …
View article: Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses
Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses Open
Vaccination with Vi capsular polysaccharide (Vi-PS) or protein-Vi typhoid conjugate vaccine (TCV) can protect adults against Salmonella Typhi infections. TCVs offer better protection than Vi-PS in infants and may offer better protection in…
View article: Latent Cytomegalovirus Infection and Previous Capsular Polysaccharide Vaccination Predict Poor Vaccine Responses in Older Adults, Independent of Chronic Kidney Disease
Latent Cytomegalovirus Infection and Previous Capsular Polysaccharide Vaccination Predict Poor Vaccine Responses in Older Adults, Independent of Chronic Kidney Disease Open
Background Patients with chronic kidney disease (CKD) are more prone to severe infection. Vaccination is a key strategy to reduce this risk. Some studies suggest vaccine efficacy may be reduced in patients with CKD, despite preserved maint…
View article: Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain <i>Salmonella</i>
Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain <i>Salmonella</i> Open
Clearance of intracellular infections caused by Salmonella Typhimurium (STm) requires IFN-γ and the Th1-associated transcription factor T-bet. Nevertheless, whereas IFN-γ−/− mice succumb rapidly to STm infections, T-bet−/− mice do not. In …
View article: Use of Regulatory T Cells as a Cellular Therapy for Transplant Rejection/Autoimmunity
Use of Regulatory T Cells as a Cellular Therapy for Transplant Rejection/Autoimmunity Open
Foxp3+ regulatory T cells (Treg) are a crucial sub-population of T cells in the control of immunity and the maintenance of immunological tolerance aiding the prevention of autoimmunity. As such Treg have been proposed to be a candidate cel…
View article: Abstracts presented at the South West ENT Academic Meeting 2018, Bath, UK
Abstracts presented at the South West ENT Academic Meeting 2018, Bath, UK Open
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View article: Global and regional estimates of the morbidity due to type I diabetes among children aged 0-4 years: a systematic review and analysis
Global and regional estimates of the morbidity due to type I diabetes among children aged 0-4 years: a systematic review and analysis Open
The identified large variation in incidence estimates for different parts of the world, along with scarcity of information and the identified strong temporal increase in T1DM incidence suggest a clear need for further research into this su…
View article: 19941014
19941014 Open
Where on campus can one ca!yakitori, watch sumo wrestling and sing karaoke all in one Saturday?Only at TIUA.where the
View article: Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity
Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity Open
Although strategies that block FOXP3-dependent regulatory T cell function (CTLA4 blockade) and the inhibitory receptor PD1 have shown great promise in promoting antitumor immune responses in humans, their widespread implementation for canc…
View article: Inflammation-Induced Formation Of Fat-Associated Lymphoid Clusters
Inflammation-Induced Formation Of Fat-Associated Lymphoid Clusters Open
Fat-associated lymphoid clusters (FALCs) are a recently discovered type of lymphoid tissue associated with visceral fat. Here we show that distribution of FALCs was heterogeneous with the pericardium containing large numbers of these clust…
View article: Development of a Pediatric Adverse Events Terminology
Development of a Pediatric Adverse Events Terminology Open
In 2009, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Pediatric Terminology Harmonization Initiative to establish a core library of terms to facilitate the acquisition and shar…