Explanipedia

The Impact of Myopia on Regional Visual Field Loss and Progression in Glaucoma Open

Anagha Lokhande, Lifei Song, Yueyin Pang, Yan Luo, Louis R. Pasquale , et al. · 2025

We provide evidence for the relationship between SE and VF progression and inform clinical practice by highlighting even mild myopia as a highly prevalent possible risk factor for glaucoma progression.

Equity-enhanced glaucoma progression prediction from OCT with knowledge distillation Open

Sulaiman O Afolabi, Leila Gheisi, Jing Shan, Lucy Q. Shen, Mengyu Wang , et al. · 2025

Glaucoma is a progressive disease that can lead to permanent vision loss, making progression prediction vital for guiding effective treatment. Deep learning aids progression prediction but may yield unequal outcomes across demographic grou…

Deep Learning with Disc Photos or OCT Scans in Glaucoma Detection Open

Abhilash Katuru, In Young Chung, Iyad Majid, Lucy Q. Shen, Mengyu Wang · 2025

New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area Open

Julia V. Stingl, C. E. Braun, S Walter, Jasmin Rezapour, Felix Mathias Wagner , et al. · 2025

The novel thresholds for small and LOD-C will help to account for the effects of disc status on RNFL and MRW. They will furthermore help clinicians to better diagnose children with suspicious discs for glaucoma.

Equitable artificial intelligence for glaucoma screening with fair identity normalization Open

Min Shi, Yan Luo, Yu Tian, Lucy Q. Shen, Nazlee Zebardast , et al. · 2025

Glaucoma is the leading cause of irreversible blindness globally. Research indicates a disproportionate impact of glaucoma on racial and ethnic minorities. Existing deep learning models for glaucoma detection might not achieve equitable pe…

Impact of Demographics on Regional Visual Field Loss and Deterioration in Glaucoma Open

Yueyin Pang, Melody Tang, Min Shi, Yu Tian, Yan Luo , et al. · 2024

This study furthered our understanding of racial, ethnic, and socioeconomic disparities in glaucoma outcomes. Understanding the VF loss burden in different racial, ethnic, and socioeconomic groups may guide more effective glaucoma screenin…

Transformer-Based Deep Learning Prediction of 10-Degree Humphrey Visual Field Tests From 24-Degree Data Open

Min Shi, Anagha Lokhande, Yu Tian, Yan Luo, M. Eslami , et al. · 2024

The predicted 10-2 VF has the potential to improve glaucoma diagnosis.

Management of a posterior tube exposure Open

Laura Barna, Lucy Q. Shen · 2024

Harvard Glaucoma Fairness: A Retinal Nerve Disease Dataset for Fairness Learning and Fair Identity Normalization Open

Yan Luo, Yu Tian, Min Shi, Louis R. Pasquale, Lucy Q. Shen , et al. · 2024

Fairness (also known as equity interchangeably) in machine learning is important for societal well-being, but limited public datasets hinder its progress. Currently, no dedicated public medical datasets with imaging data for fairness learn…

Equitable Artificial Intelligence for Glaucoma Screening with Fair Identity Normalization Open

Min Shi, Yan Luo, Yu Tian, Lucy Q. Shen, Tobias Elze , et al. · 2023

Objective To develop an equitable artificial intelligence model for glaucoma screening. Design Cross-sectional study. Participants 7,418 optical coherence tomography (OCT) paired with reliable visual field (VF) measurements of 7,418 patien…

Comparison of Structural and Functional Features in Primary Angle Closure and Open Angle Glaucomas Open

Jessica A. Sun, Melissa Yuan, Grace E. Johnson, Louis R. Pasquale, Michael V. Boland , et al. · 2023

Précis: Using a large data set, we showed structural and functional differences between primary angle closure glaucoma (PACG) and primary open angle glaucoma (POAG). Primary angle closure glaucoma has relative structural preservation and w…

Artifact Correction in Retinal Nerve Fiber Layer Thickness Maps Using Deep Learning and Its Clinical Utility in Glaucoma Open

Min Shi, Jessica A. Sun, Anagha Lokhande, Yu Tian, Yan Luo , et al. · 2023

Our model improves clinical usability of RNFLT maps with artifacts.

Steroid Response Following Dropless Cataract Surgery Using Subconjunctival Triamcinolone Open

Annie M. Wu, Kristen Pitts, Roberto Pineda, Sherleen Chen, Mengyu Wang , et al. · 2023

Dropless cataract surgery increases the risk of prolonged steroid response postoperatively. Patients with glaucoma have an increased risk of steroid response and may not be good candidates for dropless cataract surgery with subconjunctival…

Artifact-Tolerant Clustering-Guided Contrastive Embedding Learning for Ophthalmic Images in Glaucoma Open

Min Shi, Anagha Lokhande, Mojtaba S. Fazli, Vishal Sharma, Yu Tian , et al. · 2023

Ophthalmic images, along with their derivatives like retinal nerve fiber layer (RNFL) thickness maps, play a crucial role in detecting and monitoring eye diseases such as glaucoma. For computer-aided diagnosis of eye diseases, the key tech…

Association between Heat Shock Protein-Specific T-Cell Counts and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma Open

Chhavi Saini, Shuhong Jiang, Julia Devlin, Pan Li, Yizhen Tang , et al. · 2023

Proprietary or commercial disclosure may be found after the references.

Transscleral vs endoscopic cyclophotocoagulation: safety and efficacy when combined with phacoemulsification Open

Abraham Nirappel, Emma Klug, Cameron Neeson, Mari Chachanidze, Hani El Helwe , et al. · 2023

Incidence and risk factors for glaucoma development and progression after corneal transplantation Open

Chhavi Saini, Emma Davies, Lawson Ung, James Chodosh, Joseph B. Ciolino , et al. · 2022

Combined Model of OCT Angiography and Structural OCT Parameters to Predict Paracentral Visual Field Loss in Primary Open-Angle Glaucoma Open

Christine Xu, Chhavi Saini, Mengyu Wang, Julia Devlin, Haobing Wang , et al. · 2022

Expanding relationship science to unpartnered singles: What predicts life satisfaction? Open

Lisa C. Walsh, Ariana Gonzales, Lucy Q. Shen, Anthony Rodriguez, Victor A. Kaufman · 2022

Singles are an understudied yet growing segment of the adult population. The current study aims to expand the lens of relationship science by examining the well-being of unpartnered, single adults using latent profile analysis. We recruite…

Artifact-Tolerant Clustering-Guided Contrastive Embedding Learning for Ophthalmic Images Open

Min Shi, Anagha Lokhande, Mojtaba S. Fazli, Vishal Sharma, Yu Tian , et al. · 2022

Ophthalmic images and derivatives such as the retinal nerve fiber layer (RNFL) thickness map are crucial for detecting and monitoring ophthalmic diseases (e.g., glaucoma). For computer-aided diagnosis of eye diseases, the key technique is …

Transscleral vs endoscopic cyclophotocoagulation: safety and efficacy when combined with phacoemulsification Open

Abraham Nirappel, Emma Klug, Cameron Neeson, Mari Chachanidze, Nathan Hall , et al. · 2022

Purpose To compare the effectiveness and safety of phacoemulsification combined with endoscopic cyclophotocoagulation (phaco/ECP), phacoemulsification combined with MicroPulse transscleral cyclophotocoagulation (phaco/MP-TSCPC), and phacoe…

Assessing Surface Shapes of the Optic Nerve Head and Peripapillary Retinal Nerve Fiber Layer in Glaucoma with Artificial Intelligence Open

Chhavi Saini, Lucy Q. Shen, Louis R. Pasquale, Michael V. Boland, David S. Friedman , et al. · 2022

The ONH and RNFL surface shape patterns quantified by unsupervised AI techniques improved the structure-function relationship and subsequent VF loss rate prediction.

Transscleral vs Endoscopic Cyclophotocoagulation: Safety and Efficacy When Combined with Phacoemulsification Open

Abraham Nirappel, Emma Klug, Cameron Neeson, Mari Chachanidze, Nathan Hall , et al. · 2021

Precis: Phacoemulsification combined with MicroPulse transscleral cyclophotocoagulation appears to provide significantly greater long-term IOP reduction than phacoemulsification combined with endoscopic cyclophotocoagulation without compro…

The Prevalence of Autoimmune Diseases in Patients with Primary Open-Angle Glaucoma Undergoing Ophthalmic Surgeries Open

Maltish Lorenzo, Julia Devlin, Chhavi Saini, Kin‐Sang Cho, Eleftherios I. Paschalis , et al. · 2021

The Effect of Ametropia on Glaucomatous Visual Field Loss Open

Eun Young Choi, Raymond C S Wong, Thuzar Thein, Louis R. Pasquale, Lucy Q. Shen , et al. · 2021

Myopia has been discussed as a risk factor for glaucoma. In this study, we characterized the relationship between ametropia and patterns of visual field (VF) loss in glaucoma. Reliable automated VFs (SITA Standard 24-2) of 120,019 eyes fro…

Development and Comparison of Machine Learning Algorithms to Determine Visual Field Progression Open

Osamah Saeedi, Michael V. Boland, Loris D’Acunto, Ramya Swamy, Vikram Hegde , et al. · 2021

MLCs may help to determine visual field progression.

Artificial Intelligence Assessment of Optic Cup Shape Patterns in Glaucoma Open

Mengyu Wang, Lucy Q. Shen, Louis R. Pasquale, Thao D. Nguyen, Yangjiani Li , et al. · 2021

Incidence and Prognostic Factors for Glaucoma Progression after Corneal Transplantation in Patients with Pre-existing Glaucoma Open

Chhavi Saini, Emma Davies, Lawson Ung, James Chodosh, Joseph B. Ciolino , et al. · 2021

Spatial Patterns of Preclinical Visual Fields in Glaucoma Open

Eun Young Choi, Lucy Q. Shen, Louis R. Pasquale, Michael V. Boland, Pradeep Y. Ramulu , et al. · 2021

Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma Open

Marissa K. Shoji, Clara C. Cousins, Chhavi Saini, Rafaella Nascimento e Silva, Mengyu Wang , et al. · 2021

The concomitant abnormalities in nailfold capillaries and relevant ocular vascular beds in POAG suggest that the microvasculature may be a target for POAG treatment.

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