Charlotte Hammerbeck-Ward
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View article: Racial disparities in acute care utilization among individuals with myasthenia gravis
Racial disparities in acute care utilization among individuals with myasthenia gravis Open
Objective In myasthenia gravis (MG), evidence on the impact of social determinants of health on disparities in disease burden and healthcare resource utilization is limited. This study aimed to investigate the independent association betwe…
View article: SpaFlow: a Nextflow pipeline for QC and clustering of MxIF datasets
SpaFlow: a Nextflow pipeline for QC and clustering of MxIF datasets Open
Motivation Multiplex immunofluorescence (MxIF) enables the quantification of multiple protein markers at a single-cell level while preserving spatial information, offering a powerful tool for studying tissue microenvironments. However, the…
View article: Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study
Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study Open
Objective Skull base chordoma and chondrosarcoma are distinct sarcomas of the skull base but share significant therapeutic challenges due to their proximity to critical neurovascular structures, making surgical resection difficult. We soug…
View article: Recurrence of Resected Skull Base Meningiomas during Long-term Follow-up: Incidence and Predisposing Factors
Recurrence of Resected Skull Base Meningiomas during Long-term Follow-up: Incidence and Predisposing Factors Open
Introduction Skull base meningiomas (SBMs) are often subtotally resected and there is a paucity of evidence regarding the long-term rates of postoperative tumor progression. We aimed to investigate the factors that influence tumor recurren…
View article: Improved Recovery after Vestibular Schwannoma Excision with Intratympanic Gentamicin Prehabilitation
Improved Recovery after Vestibular Schwannoma Excision with Intratympanic Gentamicin Prehabilitation Open
Objective Translabyrinthine excision of a vestibular schwannoma is associated with acute vestibular failure. Preoperative intratympanic gentamicin (ITG) injections can improve objective balance function after surgery but its clinical benef…
View article: Evidence for inflammation in normal-appearing brain regions in patients with growing sporadic vestibular schwannoma: A PET study
Evidence for inflammation in normal-appearing brain regions in patients with growing sporadic vestibular schwannoma: A PET study Open
Background Nonauditory symptoms can be a prominent feature in patients with sporadic vestibular schwannoma (VS), but the cause of these symptoms is unknown. Inflammation is hypothesized to play a key role in the growth and symptomatic pres…
View article: Changes in audiovestibular handicap following treatment of vestibular schwannomas
Changes in audiovestibular handicap following treatment of vestibular schwannomas Open
Objective This study aimed to assess degree of audiovestibular handicap in patients with vestibular schwannoma. Methods Audiovestibular handicap was assessed using the Hearing Handicap Inventory, Tinnitus Handicap Inventory and Dizziness H…
View article: The management of symptomatic hyperostotic bilateral spheno-orbital meningiomas: patient series
The management of symptomatic hyperostotic bilateral spheno-orbital meningiomas: patient series Open
BACKGROUND The occurrence of hyperostotic bilateral spheno-orbital meningiomas (BSOMs) is very rare. Patients present with bilateral symptoms and require bilateral treatment. This series describes 6 patients presenting to 2 UK neurosurgica…
View article: The clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis
The clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis Open
NF2-schwannomatosis is the most common genetic predisposition syndrome associated with meningioma. Meningioma in NF2-schwannomatosis is a major source of morbidity and mortality. This is due to accumulative tumor burden in patients with sy…
View article: Radiation treatment of benign tumors in NF2-related-schwannomatosis: A national study of 266 irradiated patients showing a significant increase in malignancy/malignant progression
Radiation treatment of benign tumors in NF2-related-schwannomatosis: A national study of 266 irradiated patients showing a significant increase in malignancy/malignant progression Open
Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from treatment centers suggest safety despite apparent radiation-associated malignancy being reported. We determined…
View article: Surgery versus radiosurgery for vestibular schwannoma: Shared decision making in a multidisciplinary clinic
Surgery versus radiosurgery for vestibular schwannoma: Shared decision making in a multidisciplinary clinic Open
Background Our neurosurgical unit adopted a model of shared decision-making (SDM) based on multidisciplinary clinics for vestibular schwannoma (VS). A unique feature of this clinic is the interdisciplinary counseling process with a surgeon…
View article: Genome-wide association analysis identifies a susceptibility locus for sporadic vestibular schwannoma at 9p21
Genome-wide association analysis identifies a susceptibility locus for sporadic vestibular schwannoma at 9p21 Open
Vestibular schwannomas are benign nerve sheath tumours that arise on the vestibulocochlear nerves. Vestibular schwannomas are known to occur in the context of tumour predisposition syndromes NF2-related and LZTR1-related schwannomatosis. H…
View article: Translabyrinthine resection of NF2 associated vestibular schwannoma with cochlear implant insertion
Translabyrinthine resection of NF2 associated vestibular schwannoma with cochlear implant insertion Open
The authors present the case of a 24-year-old female with neurofibromatosis type 2. Growth of the left vestibular schwannoma and progressive hearing loss prompted the decision to proceed to translabyrinthine resection with cochlear nerve p…
View article: Long-Term Outcomes of the Electrically Unresponsive, Anatomically Intact Facial Nerve Following Vestibular Schwannoma Surgery
Long-Term Outcomes of the Electrically Unresponsive, Anatomically Intact Facial Nerve Following Vestibular Schwannoma Surgery Open
Objective The study aimed to determine long-term outcomes in patients with intraoperative electrical conduction block in an anatomically intact facial nerve (FN). Methods Single center retrospective review of prospectively collected databa…
View article: CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service
CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service Open
Background The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intra…
View article: Disease course of neurofibromatosis type 2: a 30-year follow-up study of 353 patients seen at a single institution
Disease course of neurofibromatosis type 2: a 30-year follow-up study of 353 patients seen at a single institution Open
Background Limited data exist on the disease course of neurofibromatosis type 2 (NF2) to guide clinical trial design. Methods A prospective database of patients meeting NF2 diagnostic criteria, reviewed between 1990 and 2020, was evaluated…
View article: The importance of genetic counseling and screening for people with pathogenic <scp><i>SMARCE1</i></scp> variants: A family study
The importance of genetic counseling and screening for people with pathogenic <span><i>SMARCE1</i></span> variants: A family study Open
Clear cell meningioma (CCM) is a rare variant of meningioma. In recent years, an association between cranial and spinal CCMs and germline loss of function mutations in the SMARCE1 gene ( SWI/SNF chromatin remodeling complex subunit gene) h…
View article: Beyond Antoni: A Surgeon's Guide to the Vestibular Schwannoma Microenvironment
Beyond Antoni: A Surgeon's Guide to the Vestibular Schwannoma Microenvironment Open
Introduction Vestibular schwannomas (VS) are histologically benign tumors arising from cranial nerve VIII. Far from a homogenous proliferation of Schwann cells, mounting evidence has highlighted the complex nature of the inflammatory micro…
View article: The microenvironment in sporadic and neurofibromatosis type II–related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study
The microenvironment in sporadic and neurofibromatosis type II–related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study Open
OBJECTIVE Inflammation and angiogenesis may play a role in the growth of sporadic and neurofibromatosis type 2 (NF2)–related vestibular schwannoma (VS). The similarities in microvascular and inflammatory microenvironment have not been inve…
View article: Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma
Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma Open
We present the first in vivo imaging evidence of increased inflammation within growing sporadic VS. Our results demonstrate that 11C-(R)-PK11195 specific binding and DCE-MRI derived parameters can be used as imaging biomarkers of inflammat…
View article: Familial unilateral vestibular schwannoma is rarely caused by inherited variants in the <i>NF2</i> gene
Familial unilateral vestibular schwannoma is rarely caused by inherited variants in the <i>NF2</i> gene Open
Objectives/Hypothesis Unilateral vestibular schwannoma (VS) occurs with a lifetime risk of around 1 in 1,000 and is due to inactivation of the NF2 gene, either somatically or from a constitutional mutation. It has been postulated that fami…
View article: High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient
High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient Open
BACKGROUND The Manchester criteria for neurofibromatosis type 2 (NF2) include a range of tumors, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas. OB…
View article: Revisiting neurofibromatosis type 2 diagnostic criteria to exclude <i>LZTR1</i> -related schwannomatosis
Revisiting neurofibromatosis type 2 diagnostic criteria to exclude <i>LZTR1</i> -related schwannomatosis Open
The most common etiology for unilateral VS and 2 additional NF2-associated tumors in this cohort was mosaic NF2. Germline LZTR1 and germline NF2 mutations were equally common in our cohort. This indicates that LZTR1 must be considered when…
View article: Petrous Bone Cholesteatoma: The Manchester Experience
Petrous Bone Cholesteatoma: The Manchester Experience Open
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View article: DWI imaging in extensive petrous bone cholesteatoma
DWI imaging in extensive petrous bone cholesteatoma Open
An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.