Lucy H. Young
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View article: Clinical Characteristics, Outcomes, and Complications Associated With Delayed Diagnosis of Intraocular Foreign Body
Clinical Characteristics, Outcomes, and Complications Associated With Delayed Diagnosis of Intraocular Foreign Body Open
Purpose: To describe the clinical characteristics, outcomes, and complications in cases of intraocular foreign bodies (IOFBs) when the diagnosis is missed or delayed. Methods: This nonconsecutive case series was a retrospective multicenter…
View article: Psychotropic medication use and its metabolic consequences: advocating for a patient-centred approach
Psychotropic medication use and its metabolic consequences: advocating for a patient-centred approach Open
Introduction There exponential rise in prescribing SSRIs and antipsychotic medication have highlighted the paucity of shared decision making, holistic therapies and weight management programmes. Guidelines are vague about checkpoints and d…
View article: P17.20.A REVERSAL OF EPIGENETIC DYSREGULATION IN BREAST CANCER BRAIN METASTASIS VIA HDAC1/2 INHIBITION
P17.20.A REVERSAL OF EPIGENETIC DYSREGULATION IN BREAST CANCER BRAIN METASTASIS VIA HDAC1/2 INHIBITION Open
BACKGROUND Breast cancer metastasising to the brain poses significant clinical challenges due to its severe prognosis and limited treatment options. Investigating the molecular mechanisms behind breast cancer brain metastasis (BCBM) is cru…
View article: SP10.3 Colectomy for Inflammatory Bowel Disease (IBD) – use of the National Consultant Information Programme (NCIP) to highlight colorectal surgical practice in England
SP10.3 Colectomy for Inflammatory Bowel Disease (IBD) – use of the National Consultant Information Programme (NCIP) to highlight colorectal surgical practice in England Open
Introduction The NCIP tool uses HES data from Trusts to understand the spread and variation of a range of surgical procedures. There are two forms of IBD; Crohn’s and Ulcerative Colitis (UC). This work uses NCIP to contextualise data and u…
View article: Angiographic Method Using Green Porphyrinew In Primmate Eyes
Angiographic Method Using Green Porphyrinew In Primmate Eyes Open
An angiographic method to observe the condition of blood vessels, including neovasculature in the eyes of living primates using green porphyrins and light at a wavelength of 550-700 nm to effect fluorescence is disclosed.
View article: Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial
Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial Open
The UK National Institute for Health Research Health Technology Assessment Programme.
View article: P02.01 A strategy to personalize the use of radiation in patients with brain metastasis based on S100A9-mediated resistance
P02.01 A strategy to personalize the use of radiation in patients with brain metastasis based on S100A9-mediated resistance Open
BACKGROUND Finding effective treatment options for patients with brain metastasis remains an unmet need. Given the limitations imposed by the blood-brain-barrier for systemic approaches, radiotherapy offers a superior ability to access the…
View article: The effect of sample medication use on subsequent anti-VEGF agent selection for neovascular age-related macular degeneration
The effect of sample medication use on subsequent anti-VEGF agent selection for neovascular age-related macular degeneration Open
Purpose: To examine the effect of medication sample use (ranibizumab or aflibercept) on future anti-vascular endothelial growth factor (VEGF) agent selection in neovascular age-related macular degeneration (nvAMD). Design: Retrospective co…
View article: Biallelic <i>RP1</i>-associated retinal dystrophies: Expanding the mutational and clinical spectrum.
Biallelic <i>RP1</i>-associated retinal dystrophies: Expanding the mutational and clinical spectrum. Open
Biallelic RP1 mutations cause a broad spectrum of retinal disease. Exon 2 missense mutations are a significant contributor to disease and can be associated with a considerably later onset of retinitis pigmentosa than that typically associa…
View article: Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays
Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays Open
The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isola…
View article: Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina Open
Significance Extracellular tissue debris accumulates with aging and in the most prevalent central-vision-threatening eye disorder, age-related macular degeneration (AMD). In this work, we discovered that lysosome-associated membrane protei…
View article: Sympathetic Ophthalmia
Sympathetic Ophthalmia Open
Sympathetic ophthalmia is a rare, bilateral, diffuse granulomatous form of uveitis that occurs after either surgical or accidental trauma to the uvea of one eye, usually 3 months after injury. The eye sustaining the injury is the "exciting…
View article: Cat-Scratch Disease
Cat-Scratch Disease Open
Cat-scratch disease (CSD) was first recognized by Parinaud in 1889 in three patients with granulomatous conjunctivitis, preauricular lymphadenopathy, chronic fever, and contact with animals. This constellation of symptoms initially became …
View article: <i>Toxoplasma</i> GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors
<i>Toxoplasma</i> GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors Open
The parasite Toxoplasma can cause birth defects and severe disease in immunosuppressed patients. Strain differences in pathogenicity exist, and these differences are due to polymorphic effector proteins that Toxoplasma secretes into the ho…
View article: Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration
Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration Open
Contradictory data have been presented regarding the implication of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in age-related macular degeneration (AMD), the leading cause of vision loss in the Western world. …
View article: Intravitreal injection of polysorbate 80: a functional and morphological study
Intravitreal injection of polysorbate 80: a functional and morphological study Open
Objective : to determine the functional and morphological effects at rabbits retina of PS80 concentration used in the preparation of intravitreal drugs. Methods: eleven New Zealand rabbits received a intravitreal injection of 0.1ml of PS80…
View article: The human immune response to Toxoplasma: Autophagy versus cell death
The human immune response to Toxoplasma: Autophagy versus cell death Open
Author(s): Krishnamurthy, Shruthi; Konstantinou, Eleni K; Young, Lucy H; Gold, Daniel A; Saeij, Jeroen PJ
View article: Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment
Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment Open
High-dose statins may result in resolution of drusenoid pigment epithelial detachments (PEDs) and improvement in VA, without atrophy or neovascularization in a high-risk subgroup of AMD patients. Confirmation from larger studies is warrant…
View article: Transcriptional Analysis of Murine Macrophages Infected with Different <i>Toxoplasma</i> Strains Identifies Novel Regulation of Host Signaling Pathways
Transcriptional Analysis of Murine Macrophages Infected with Different <i>Toxoplasma</i> Strains Identifies Novel Regulation of Host Signaling Pathways Open
Most isolates of Toxoplasma from Europe and North America fall into one of three genetically distinct clonal lineages, the type I, II and III lineages. However, in South America these strains are rarely isolated and instead a great variety…