Ludi E. Smeele
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View article: Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial
Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial Open
Patients with cutaneous squamous cell carcinoma (CSCC) frequently require mutilating surgery and adjuvant radiotherapy (RT). CSCC has been demonstrated to be highly responsive to neoadjuvant anti-PD-1 immune-checkpoint blockade (ICB). Howe…
View article: Surgeon’s perceptions on 3D visualization methods in parotid gland tumor surgery
Surgeon’s perceptions on 3D visualization methods in parotid gland tumor surgery Open
Introduction Recent advances in high-resolution MRI and reconstruction techniques offer new opportunities to enhance visualization of the facial nerve and its relationship to parotid tumors in 3D models. The aim of this study is twofold: f…
View article: Improved ground truth annotation by multimodal image registration from 3D ultrasound to histopathology for resected tongue carcinoma
Improved ground truth annotation by multimodal image registration from 3D ultrasound to histopathology for resected tongue carcinoma Open
Objectives This study’s objectives are (1) to investigate the registration accuracy from intraoperative ultrasound (US) to histopathological images, (2) to assess the agreement and correlation between measurements in registered 3D US and h…
View article: Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer
Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer Open
Purpose Treatment of head and neck cancer (HNC) may lead to obstructive sleep apnea (OSA), but conclusive results on the prevalence of OSA are lacking. The objective of this study is to investigate the prevalence of OSA in a cohort of pati…
View article: The implementation of a multidisciplinary, electronic health record embedded care pathway to improve structured data recording and decrease electronic health record burden
The implementation of a multidisciplinary, electronic health record embedded care pathway to improve structured data recording and decrease electronic health record burden Open
Implementing an EHR embedded care pathway with structured documentation led to decreased EHR burden.
View article: National Improvement of Waiting Times: First Results From the Dutch Head and Neck Audit
National Improvement of Waiting Times: First Results From the Dutch Head and Neck Audit Open
Objective Timely treatment initiation in head and neck cancer (HNC) care is of great importance regarding survival, oncological, functional, and psychological outcomes. Therefore, waiting times are assessed in the Dutch Head and Neck Audit…
View article: Corrigendum to ‘Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up’
Corrigendum to ‘Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up’ Open
The authors regret that there were errors in the text and published figures. The authors would like to apologise for any inconvenience caused.
View article: The observational clinical registry (cohort design) of the European Reference Network on Rare Adult Solid Cancers: The protocol for the rare head and neck cancers
The observational clinical registry (cohort design) of the European Reference Network on Rare Adult Solid Cancers: The protocol for the rare head and neck cancers Open
Introduction Care for head and neck cancers is complex in particular for the rare ones. Knowledge is limited and histological heterogeneity adds complexity to the rarity. There is a wide consensus that to support clinical research on rare …
View article: Imaging in rhabdomyosarcoma: a patient journey
Imaging in rhabdomyosarcoma: a patient journey Open
Rhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site in the body, with most common presentations in the head and neck, genitourinary tract and ex…
View article: Developments in the Surgical Approach to Staging and Resection of Rhabdomyosarcoma
Developments in the Surgical Approach to Staging and Resection of Rhabdomyosarcoma Open
Although survival after rhabdosarcoma treatment has improved over the years, one third of patients still develop locoregional relapse. This review aims to highlight developments pertaining to staging and local treatment of specific RMS tum…
View article: Development and validation of automated electronic health record data reuse for a multidisciplinary quality dashboard
Development and validation of automated electronic health record data reuse for a multidisciplinary quality dashboard Open
Objective To describe the development and validation of automated electronic health record data reuse for a multidisciplinary quality dashboard. Materials and methods Comparative study analyzing a manually extracted and an automatically ex…
View article: Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up
Salivary gland cancer: ESMO–European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment and follow-up Open
• This ESMO–EURACAN Clinical Practice Guideline provides key recommendations for managing salivary gland cancer. • The guideline covers clinical and pathological diagnosis, staging and risk assessment, treatment and follow-up. • Treatment …
View article: Quantifying the Electronic Health Record Burden in Head and Neck Cancer Care
Quantifying the Electronic Health Record Burden in Head and Neck Cancer Care Open
Background Although the main task of health care providers is to provide patient care, studies show that increasing amounts of time are spent on documentation. Objective To quantify the time and effort spent on the electronic health record…
View article: The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma
The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma Open
Introduction Febrile neutropenia (FN) is a potential life-threatening complication of myelosuppressive chemotherapy, particularly when induced by infection. There is evidence that FN can originate from the oral cavity, but its contribution…
View article: The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation
The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation Open
Background Late side effects of radiotherapy in patients with head and neck cancer (HNCPs) result in decreased tissue vascularity, a compromised healing capacity and spontaneous breakdown of tissue. The aim of this study was to examine the…
View article: Intra-operative resection margin model of tongue carcinoma using 3D reconstructed ultrasound
Intra-operative resection margin model of tongue carcinoma using 3D reconstructed ultrasound Open
Background: Although an oncological surgeon aims to remove tongue cancer with a margin of no less than 5 mm, 85% of margins are reported as close or positive (<5 mm). Currently, the only feedback on the status of margins is provided by fro…