Ludis̆e Málková
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View article: Pharmacological Inhibition of the Nucleus Accumbens Increases Dyadic Social Interaction in Macaques
Pharmacological Inhibition of the Nucleus Accumbens Increases Dyadic Social Interaction in Macaques Open
The nucleus accumbens (NAc) is a central component of the brain circuitry that mediates motivated behavior, including reward processing. Since the rewarding properties of social stimuli have a vital role in guiding behavior (both in humans…
View article: Hippocampal lesions impair non‐navigational spatial memory in macaques
Hippocampal lesions impair non‐navigational spatial memory in macaques Open
Decades of studies robustly support a critical role for the hippocampus in spatial memory across a wide range of species. Hippocampal damage produces clear and consistent deficits in allocentric spatial memory that requires navigating thro…
View article: Pharmacological Inactivation of the Bed Nucleus of the Stria Terminalis Increases Affiliative Social Behavior in Rhesus Macaques
Pharmacological Inactivation of the Bed Nucleus of the Stria Terminalis Increases Affiliative Social Behavior in Rhesus Macaques Open
The bed nucleus of the stria terminalis (BNST) has been implicated in a variety of social behaviors, including aggression, maternal care, mating behavior, and social interaction. Limited evidence from rodent studies suggests that activatio…
View article: Macaques fail to develop habit responses during extended training on a reinforcer devaluation task.
Macaques fail to develop habit responses during extended training on a reinforcer devaluation task. Open
Goal-directed behavior and habit are parallel and, at times, competing processes. The relative balance of flexible, goal-directed responding as compared to inflexible habitual responding is highly dependent on experience (e.g., training hi…
View article: Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques.
Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques. Open
Cholinergic neurotransmission within the hippocampus has long been suggested to play a pivotal role in memory processing, based partly on the assumption that the well-established amnestic effects of systemic cholinergic receptor blockade a…
View article: Inhibition of the Deep and Intermediate Layers of the Superior Colliculus Disrupts Sensorimotor Gating in Monkeys
Inhibition of the Deep and Intermediate Layers of the Superior Colliculus Disrupts Sensorimotor Gating in Monkeys Open
The deep and intermediate layers of the superior colliculus (DLSC) respond to visual, auditory, and tactile inputs and act as a multimodal sensory association area. In turn, activity in the DLSC can drive orienting and avoidance responses—…
View article: The Parahippocampal Cortex and its Functional Connection with the Hippocampus are Critical for Nonnavigational Spatial Memory in Macaques
The Parahippocampal Cortex and its Functional Connection with the Hippocampus are Critical for Nonnavigational Spatial Memory in Macaques Open
The Hamilton Search Task (HST) is a test of nonnavigational spatial memory that is dependent on the hippocampus. The parahippocampal cortex (PHC) is a major route for spatial information to reach the hippocampus, but the extent to which th…
View article: 2016 Chemogenetic workshop report
2016 Chemogenetic workshop report Open
Molecular tools - such as chemogenetics, optogenetics, and calcium sensors – have been shown in small animals, e.g., mice, zebrafish, and flies, to be powerful tools for studying the mechanisms underlying brain function. The adoption of mo…
View article: Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar
Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar Open
Neuropsychological and neuroimaging studies have suggested the presence of a fast, subcortical route for the processing of emotionally-salient visual information in the primate brain. This putative pathway consists of the superior collicul…
View article: Genetically Epilepsy-Prone Rats Display Anxiety-Like Behaviors and Neuropsychiatric Comorbidities of Epilepsy
Genetically Epilepsy-Prone Rats Display Anxiety-Like Behaviors and Neuropsychiatric Comorbidities of Epilepsy Open
Epilepsy is associated with a variety of neuropsychiatric comorbidities, including both anxiety and depression. Despite high occurrences of depression and anxiety seen in human epilepsy populations, little is known about the etiology of th…
View article: Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques
Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques Open
Reward contingencies are dynamic: outcomes that were valued at one point may subsequently lose value. Action selection in the face of dynamic reward associations requires several cognitive processes: registering a change in value of the pr…
View article: Author response: Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques
Author response: Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Reward contingencies are dyna…
View article: MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys
MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys Open
Selective, fiber-sparing excitotoxic lesions are a state-of-the-art tool for determining the causal contributions of different brain areas to behavior. For nonhuman primates especially, it is advantageous to keep subjects with high-quality…
View article: Defensive Vocalizations and Motor Asymmetry Triggered by Disinhibition of the Periaqueductal Gray in Non-human Primates
Defensive Vocalizations and Motor Asymmetry Triggered by Disinhibition of the Periaqueductal Gray in Non-human Primates Open
Rapid and reflexive responses to threats are present across phylogeny. The neural circuitry mediating reflexive defense reactions has been well-characterized in a variety of species, for example, in rodents and cats, the detection of and s…
View article: Blockade of glutamatergic transmission in the primate basolateral amygdala suppresses active behavior without altering social interaction.
Blockade of glutamatergic transmission in the primate basolateral amygdala suppresses active behavior without altering social interaction. Open
The amygdala is an integrator of affective processing, and a key component of a network regulating social behavior. While decades of lesion studies in nonhuman primates have shown alterations in social interactions after amygdala damage, a…
View article: Development of relational memory processes in monkeys
Development of relational memory processes in monkeys Open
The present study tested whether relational memory processes, as measured by the transverse patterning problem, are late-developing in nonhuman primates as they are in humans. Eighteen macaques ranging from 3 to 36 months of age, were trai…
View article: Bidirectional Control of Social Behavior by Activity within Basolateral and Central Amygdala of Primates
Bidirectional Control of Social Behavior by Activity within Basolateral and Central Amygdala of Primates Open
Many previous studies reported loss of social interactions following permanent damage to the amygdala in nonhuman primates. In contrast, we report that transient inhibition of the basolateral amygdala triggered a profound increase in socia…
View article: Amygdala selectively modulates defensive responses evoked from the superior colliculus in non-human primates
Amygdala selectively modulates defensive responses evoked from the superior colliculus in non-human primates Open
Brain circuitry underlying defensive behaviors includes forebrain modulatory sites, e.g. the amygdala and hypothalamus, and midbrain effector regions, such as the deep/intermediate layers of the superior colliculus (DLSC). When disinhibite…