Ľudmila Vodičková
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View article: Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis
Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis Open
Introduction There is convincing evidence that overall adiposity increases the risks of several cancers. Whether the distribution of adiposity plays a similar role is unclear. Methods We used 2-sample Mendelian randomization (MR) to examin…
View article: DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study
DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study Open
In this study, we evaluated the genomic stability of oral mucosal epithelial cells (OMECs) cultured in complex media (COM) and xenobiotic-free media (XF) to assess their potential clinical application for limbal stem cell deficiency (LSCD)…
View article: Adiposity distribution and risks of twelve obesity-related cancers: a Mendelian randomization analysis
Adiposity distribution and risks of twelve obesity-related cancers: a Mendelian randomization analysis Open
Background There is convincing evidence that overall adiposity (as measured by body mass index) increases the risks of several cancers. Whether there are similar relationships between these cancers and the distribution of adiposity is uncl…
View article: <i>TACSTD2</i>expression marks the early transition to colon adenomas
<i>TACSTD2</i>expression marks the early transition to colon adenomas Open
This study aimed to address new molecular events occurring in precancerous stages of colorectal cancer (CRC) by integrated analysis of gene expression data and DNA methylation profiles. Whole-transcriptome sequencing analysis was performed…
View article: Polymorphisms within autophagy‐related genes as susceptibility biomarkers for pancreatic cancer: A meta‐analysis of three large European cohorts and functional characterization
Polymorphisms within autophagy‐related genes as susceptibility biomarkers for pancreatic cancer: A meta‐analysis of three large European cohorts and functional characterization Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients having unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Given that genetic variation within autophagy‐rela…
View article: Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance Open
View article: Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma
Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma Open
View article: Commentary: Special Issue: Current Understanding of Colorectal and Pancreatic Cancers
Commentary: Special Issue: Current Understanding of Colorectal and Pancreatic Cancers Open
The Commentary on Special Issue- Current Understanding of Colorectal and Pancreatic Cancers provides the reasoning for the selection of the contributions on pancreatic and colorectal cancer, and summarizes in brief the individual topics an…
View article: Genetic and environmental associations of nonspecific chromosomal aberrations
Genetic and environmental associations of nonspecific chromosomal aberrations Open
Nonspecific structural chromosomal aberrations (CAs) are found in around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. CAs have been used in th…
View article: Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk Open
View article: Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: a meta-analysis of four large European cohorts and functional characterization
Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: a meta-analysis of four large European cohorts and functional characterization Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. The vast majority of patients have unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Considering this fact, it is urgent…
View article: Editorial: Current understanding of genomic and chromosomal instabilities in solid malignancies
Editorial: Current understanding of genomic and chromosomal instabilities in solid malignancies Open
EDITORIAL article Front. Oncol., 24 August 2023Sec. Cancer Genetics Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1245087
View article: Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians Open
View article: The dynamics of telomere length in primary and metastatic colorectal cancer lesions
The dynamics of telomere length in primary and metastatic colorectal cancer lesions Open
View article: A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study
A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study Open
View article: The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer
The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer Open
View article: Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer
Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer Open
Despite distant metastases being the critical factor affecting patients’ survival, they remain poorly understood. Our study thus aimed to molecularly characterize colorectal cancer liver metastases (CRCLMs) and explore whether molecular pr…
View article: Supplementary Table 3 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas
Supplementary Table 3 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas Open
PDF file, 57K, Table shows list of genes analyzed by MS-HRM with their respective primers sequences and reaction conditions.
View article: Supplementary Table 2 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas
Supplementary Table 2 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas Open
PDF file, 59K, Table shows list of genes analyzed by MSP with their respective primers sequences and reaction conditions.
View article: Data from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Data from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding Open
Purpose: Colorectal cancer is routinely treated with a 5-fluorouracil (5-FU)–based chemotherapy. 5-FU incorporates into DNA, and the base excision repair (BER) pathway specifically recognizes such damage. We investigated the associa…
View article: Data from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas
Data from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas Open
Purpose: DNA repair capacity (DRC) is a determinant not only of cancer development but also of individual response to therapy. Previously, altered base and nucleotide excision repair (BER and NER) have been described in lymphocytes …
View article: Supplementary Table 3 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Supplementary Table 3 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding Open
PDF file - 86K, SNPs associated with EFS in the Training set (Cox regression for adjusted estimates).
View article: Supplementary Table 4 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Supplementary Table 4 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding Open
PDF file - 83K, Predicted miRNAs binding in SNPs significantly associated with OS in the study.
View article: Supplementary Table 1 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas
Supplementary Table 1 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas Open
PDF file, 65K, Table shows list of genes analyzed by qPCR with their respective primers sequences and reaction conditions.
View article: Supplementary Table 1 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Supplementary Table 1 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding Open
PDF file - 89K, Genotype/allele frequencies of 12 selected BER gene SNPs in cases and controls and risk of CRC (Multivariate logistic regression analysis).
View article: Supplementary Table 3 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Supplementary Table 3 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding Open
PDF file - 86K, SNPs associated with EFS in the Training set (Cox regression for adjusted estimates).
View article: Supplementary Table 2 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas
Supplementary Table 2 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas Open
PDF file, 59K, Table shows list of genes analyzed by MSP with their respective primers sequences and reaction conditions.
View article: Supplementary Table 1 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding
Supplementary Table 1 from Variation within 3′-UTRs of Base Excision Repair Genes and Response to Therapy in Colorectal Cancer Patients: A Potential Modulation of microRNAs Binding Open
PDF file - 89K, Genotype/allele frequencies of 12 selected BER gene SNPs in cases and controls and risk of CRC (Multivariate logistic regression analysis).
View article: Supplementary Table 3 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas
Supplementary Table 3 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas Open
PDF file, 57K, Table shows list of genes analyzed by MS-HRM with their respective primers sequences and reaction conditions.
View article: Supplementary Table 1 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas
Supplementary Table 1 from Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas Open
PDF file, 65K, Table shows list of genes analyzed by qPCR with their respective primers sequences and reaction conditions.