Ludovic Couty
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View article: Blood-borne sphingosine 1-phosphate maintains vascular resistance and cardiac function
Blood-borne sphingosine 1-phosphate maintains vascular resistance and cardiac function Open
G protein-coupled receptors (GPCRs) are key regulators of cardiovascular function that provide targets for the treatment of cardiovascular disease. Sphingosine 1-phosphate (S1P) is an erythrocyte- and platelet-derived lipid mediator with c…
View article: Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature
Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature Open
Aims Circulating levels of sphingosine 1-phosphate (S1P), an HDL-associated ligand for the endothelial cell (EC) protective S1P receptor-1 (S1PR1), are reduced in disease states associated with endothelial dysfunction. Yet, as S1PR1 has hi…
View article: Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock Open
Sphingosine-1-phosphate (S1P) is a potent lipid mediator that is secreted by several cell types. We recently showed that Mfsd2b is an S1P transporter from hematopoietic cells that contributes approximately 50% plasma S1P. Here we report th…
View article: Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and protection of anaphylaxis
Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and protection of anaphylaxis Open
Summary Sphingosine-1-phosphate (S1P) is a potent lipid mediator that is secreted by several cell types to induce signaling. We recently showed that Mfsd2b is an S1P transporter from hematopoietic cells, which contributes approximately 50%…
View article: Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis Open
Aims: Peritonitis is one of the most common causes of sepsis, a serious syndrome characterized by a dysregulated systemic inflammatory response. Recent evidence suggests that Granzyme A (GzmA), a serine protease mainly expressed by NK and …
View article: Endothelial S1P <sub>1</sub> Signaling Counteracts Infarct Expansion in Ischemic Stroke
Endothelial S1P <sub>1</sub> Signaling Counteracts Infarct Expansion in Ischemic Stroke Open
Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular protective pathways may provide therapeutic targets for neurological disorders. S1P (Sphingosine 1-phosphate) signaling coordinates vascular function…
View article: Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis Open
Sepsis is a serious syndrome characterised by a dysregulated systemic inflammatory response. Here we have analysed the role and the therapeutic potential of Granzyme A (GzmA) in the pathogenesis of peritoneal sepsis using the Cecal Ligatio…
View article: Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing Open
The bioactive lipid mediator sphingosine 1-phosphate (S1P) was recently assigned critical roles in platelet biology: whereas S1P1 receptor-mediated S1P gradient sensing was reported to be essential for directing proplatelet extensions from…
View article: Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice
Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice Open
Coagulation and fibrinolytic system deregulation has been implicated in the development of idiopathic pulmonary fibrosis, a devastating form of interstitial lung disease. We used intratracheal instillation of bleomycin to induce pulmonary …
View article: Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock
Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock Open
Rationale: Sphingosine-1-phosphate (S1P) signaling is essential for vascular development and postnatal vascular homeostasis. The relative importance of S1P sources sustaining these processes remains unclear. Objective: To address the level…