Ludovic Zimmerlin
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View article: Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis
Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis Open
View article: Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a PARP-DUX4 Regulatory Axis
Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a PARP-DUX4 Regulatory Axis Open
PARP1 (ARTD1) and Tankyrases (TNKS1/TNKS2; PARP5a/5b) are poly-ADP-ribose polymerases (PARPs) with catalytic and non-catalytic functions that regulate both the genome and proteome during zygotic genome activation (ZGA), totipotent, and plu…
View article: Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a Parp-Dux4 Regulatory Axis
Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a Parp-Dux4 Regulatory Axis Open
View article: Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells
Generation of Pericytic-Vascular Progenitors from Tankyrase/PARP-Inhibitor-Regulated Naïve (TIRN) Human Pluripotent Stem Cells Open
View article: Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential
Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential Open
View article: 92 Adoptive transfer of immature myeloid cells lacking NF-κB p50 (p50-IMC) slows high-risk neuroblastoma tumor growth
92 Adoptive transfer of immature myeloid cells lacking NF-κB p50 (p50-IMC) slows high-risk neuroblastoma tumor growth Open
Background High-risk neuroblastomas, including those with MYCN gene amplification, harbor abundant myeloid cells that suppress anti-tumor immunity and favor tumor growth. Macrophages lacking the inhibitory NF-κB p50 subunit adopt an M1-pol…
View article: Long-term engraftment of mature human photoreceptors following subretinal transplantation of naïve hPSC-derived retinal organoids
Long-term engraftment of mature human photoreceptors following subretinal transplantation of naïve hPSC-derived retinal organoids Open
View article: Pleiotropic roles of tankyrase/PARP proteins in the establishment and maintenance of human naïve pluripotency
Pleiotropic roles of tankyrase/PARP proteins in the establishment and maintenance of human naïve pluripotency Open
View article: Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina Open
View article: Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naïve Diabetic Human iPSC Potentiate Efficient Revascularization of Ischemic Retina
Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naïve Diabetic Human iPSC Potentiate Efficient Revascularization of Ischemic Retina Open
Vascular regenerative therapies with conventional human induced pluripotent stem cells (hiPSC) currently remain limited by high interline variability of differentiation and poor efficiency for generating functionally transplantable vascula…
View article: Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency Open
Naïve human pluripotent stem cells (N-hPSC) with improved functionality may have a wide impact in regenerative medicine. The goal of this protocol is to efficiently revert lineage-primed, conventional human pluripotent stem cells (hPSC) ma…
View article: Human Pluripotent Stem Cells with Improved Functionality and Efficient Interspecies Chimera Potential
Human Pluripotent Stem Cells with Improved Functionality and Efficient Interspecies Chimera Potential Open
Human naïve pluripotent stem cells (N-hPSC) with improved functionality may have wide impact in human regenerative medicine due to their potential to contribute functional tissues to a developing embryo. For example, stable naïve human emb…
View article: Cell Therapy Model of Diabetic Retinopathy Using Vascular Progenitor Cells Derived from Human iPSC
Cell Therapy Model of Diabetic Retinopathy Using Vascular Progenitor Cells Derived from Human iPSC Open
View article: Capturing Human Naïve Pluripotency in the Embryo and in the Dish
Capturing Human Naïve Pluripotency in the Embryo and in the Dish Open
Although human embryonic stem cells (hESCs) were first derived almost 20 years ago, it was only recently acknowledged that they share closer molecular and functional identity to postimplantation lineage-primed murine epiblast stem cells th…
View article: Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality
Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality Open
The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve mouse embryonic stem cell (ESC) WNT …
View article: Stable Reversion of Conventional Human Pluripotent Stem Cells to a Mouse ESC-like Naïve Ground State Erases Somatic Donor Epigenetic Memory and Significantly Improves Their Hemato-Vascular Differentiation Potency
Stable Reversion of Conventional Human Pluripotent Stem Cells to a Mouse ESC-like Naïve Ground State Erases Somatic Donor Epigenetic Memory and Significantly Improves Their Hemato-Vascular Differentiation Potency Open
Human pluripotent stem cells (hPSC) share developmental, biochemical, and epigenetic commonalities with "primed" rodent post-implantation epiblast stem cells (EpiSC), which possess a less primitive, more restricted lineage-primed functiona…
View article: BMSC co-culture primed efficient non-integrated reprogramming of CB progenitors that required only four episomal Yamanaka factors on a single plasmid.
BMSC co-culture primed efficient non-integrated reprogramming of CB progenitors that required only four episomal Yamanaka factors on a single plasmid. Open
The role of a brief 3-day BMSC co-culture of GF-activated CD34+ CB progenitors following a single pulse of episomal plasmids on Day 0, and the number of episomal factors required for efficient reprogramming. The experimental des…