Ludwig G. Bauer
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View article: Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in <i>Escherichia coli</i>
Live-Cell Chemoproteomic Profiling Identifies the Uncharacterised Protein YbaA as a Direct Target of Ciprofloxacin in <i>Escherichia coli</i> Open
Fluoroquinolone antibiotics, such as ciprofloxacin, are important broad-spectrum agents for a range of bacterial infections; however, fluoroquinolone usage is increasingly challenged by the emergence of resistance. Ciprofloxacin resistance…
View article: Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence
Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence Open
Bisphosphonates (BPs) have been the major class of medicines used to treat disorders of excessive bone loss for over five decades. Recently it has been recognized that BPs may also have additional significant beneficial extra-skeletal effe…
View article: Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity
Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity Open
6-Thioguanine (6-TG), an FDA-approved antimetabolite drug, is widely used in the treatment of leukemia. Its cellular effects require metabolic activation and are regulated through interactions with various proteins such as NUDT15, which ca…
View article: Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine <i>de novo</i> synthesis
Functional profiling reveals a non-enzymatic role of NUDT5 in repressing purine <i>de novo</i> synthesis Open
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. Here, we investigate the chemical and genetic dependencies caused by mutations in th…
View article: Phenomics‐Based Discovery of Novel Orthosteric Choline Kinase Inhibitors
Phenomics‐Based Discovery of Novel Orthosteric Choline Kinase Inhibitors Open
Choline kinase alpha (CHKA) is a central mediator of cell metabolism linked to cancer and immune regulation. Cellular and clinical evaluation of CHKA has been hampered by challenges in the development of drug‐like choline kinase inhibitors…
View article: Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300 Open
The transcriptional coactivators EP300 and CREBBP are critical regulators of gene expression that share high sequence identity but exhibit nonredundant functions in basal and pathological contexts. Here, we report the development of a bifu…
View article: Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist Open
Cofactor mimicry represents an attractive strategy for the development of enzyme inhibitors but can lead to off-target effects due to the evolutionary conservation of binding sites across the proteome. Here, we uncover the ADP-ribose (ADPr…
View article: DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras Open
Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligas…
View article: A low-cost fluorescence reader for in vitro transcription and nucleic acid detection with Cas13a
A low-cost fluorescence reader for in vitro transcription and nucleic acid detection with Cas13a Open
Point-of-care testing (POCT) in low-resource settings requires tools that can operate independently of typical laboratory infrastructure. Due to its favorable signal-to-background ratio, a wide variety of biomedical tests utilize fluoresce…
View article: A low-cost fluorescence reader for in vitro transcription and nucleic acid detection with Cas13a
A low-cost fluorescence reader for in vitro transcription and nucleic acid detection with Cas13a Open
Point-of-care testing (POCT) in low-resource settings requires tools that can operate independent of typical laboratory infrastructure. Due to its favorable signal-to-background ratio, a wide variety of biomedical tests utilize fluorescenc…
View article: Supplementary Material for: Best Albuminuria Measurement to Predict Cardiovascular and Renal Events
Supplementary Material for: Best Albuminuria Measurement to Predict Cardiovascular and Renal Events Open
Background: Kidney Disease Improving Global Outcomes (KDIGO) guidelines encourage clinicians to estimate 24-hour albuminuria as albumin to creatinine ratio (ACR) from spot urine samples. However, ACR underestimates 24-hour albumin excretio…