Luezhen Yuan
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View article: Identifying regulators of aged fibroblast activation in 3D tissue models
Identifying regulators of aged fibroblast activation in 3D tissue models Open
Robust 3D tissue culture models to activate aged fibroblasts for cell-based therapies and identify regulators of such activation are still missing. In our previous study, we showed that aged fibroblasts can be activated simply through appl…
View article: Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through <scp>ERK</scp> Signaling Pathway
Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through <span>ERK</span> Signaling Pathway Open
Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging. While these changes result in altered mechanotransduction, the epigenetic basis of rejuvenating aging cells remains a significant c…
View article: Remodeling of cytoskeleton, chromatin, and gene expression during mechanical rejuvenation of aged human dermal fibroblasts
Remodeling of cytoskeleton, chromatin, and gene expression during mechanical rejuvenation of aged human dermal fibroblasts Open
Aging is associated with a progressive decline in cellular function. To reset the aged cellular phenotype, various reprogramming approaches, including mechanical routes, have been explored. However, the epigenetic mechanisms underlying cel…
View article: Compressive forces induce epigenetic activation of aged human dermal fibroblasts through ERK signaling pathway
Compressive forces induce epigenetic activation of aged human dermal fibroblasts through ERK signaling pathway Open
Age-related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging. While these changes result in altered mechanotransduction, the epigenetic basis of rejuvenating aging cells remains a significant c…
View article: Implanting mechanically reprogrammed fibroblasts for aged tissue regeneration and wound healing
Implanting mechanically reprogrammed fibroblasts for aged tissue regeneration and wound healing Open
Cell‐based therapies are essential for tissue regeneration and wound healing during aging. Autologous transplantation of aging cells is ineffective due to their increased senescence and reduced tissue remodeling capabilities. Alternatively…
View article: Fibroblast rejuvenation by mechanical reprogramming and redifferentiation
Fibroblast rejuvenation by mechanical reprogramming and redifferentiation Open
Significance The mechanical reprogramming of fibroblasts, followed by their redifferentiation into rejuvenated fibroblasts in an optimized 3D collagen matrix, made these cells more contractile and more efficient at synthesizing matrix comp…