Explanipedia

Landscape Analysis of Human Papillomavirus (HPV) Prophylactic Vaccine Clinical Trials in China Based on the NMPA Database Open

Gaoli He, Yanmei Huang, Xiaoyan Zhang, Lin Yuan, Hua Jiang , et al. · 2025

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience Open

Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi , et al. · 2025

There is a complex pathological association between neurodegenerative diseases and cancer. The epidemiological negative correlation between Parkinson's disease (PD) and brain tumor is particularly noteworthy. PD is characterized by the los…

Engineering virus-like particles for safe and versatile modeling of SARS-CoV-2 host interaction and immune escape Open

Liang Ma, Lin Yuan, Siyu Ma, Kai Chen, Yihan Lin · 2025

The effect of high-fat diet on serum metabolites in rats with heart failure: a non-targeted metabolomics approach Open

Qiuping Zhang, Minli Zhao, Lin Yuan, W.A. Day, Qiang Chen · 2025

Non‐human primate models of Parkinson's disease: Decoding pathogenesis and advancing therapies Open

Sihui Zhang, Lin Yuan, Zihan Wu, Xuguang Du, Jacek Z. Kubiak , et al. · 2025

Parkinson's disease (PD) is a neurodegenerative disorder in which the clinical manifestations include resting tremor, bradykinesia, akinesia, rigidity, and postural instability. The disease can be accompanied by non‐motor symptoms such as …

Stress granules: emerging players in neurodegenerative diseases Open

Lin Yuan, Lihong Mao, Yanming Huang, Tiago F. Outeiro, Wen Li , et al. · 2025

Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid–liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas ce…

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas Open

Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li , et al. · 2025

Adrenal incidentalomas (AIs) are commonly detected endocrine lesions, identified during imaging for unrelated conditions. These lesions exhibit considerable heterogeneity and diverse clinical outcomes. This study employed single‐cell RNA s…

The Impact of Vaccination Frequency on COVID-19 Public Health Outcomes: A Model-Based Analysis Open

Lin Yuan, Madison Stoddard, Sharanya Sarkar, Debra Van Egeren, Shruthi Mangalaganesh , et al. · 2025

Background: While the rapid deployment of SARS-CoV-2 vaccines had a significant impact on the ongoing COVID-19 pandemic, rapid viral immune evasion and waning neutralizing antibody titers have degraded vaccine efficacy. Nevertheless, vacci…

Author Correction: THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation Open

Henghui Xu, Sheng-xin Hao, Heyang Sun, Xinxin Dong, Lin Yuan , et al. · 2025

ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice Open

Heng Liu, Haiying Zhang, Han Lou, Jennifer Wang, Siyu Hao , et al. · 2024

The prevalence of cardiovascular diseases (CVDs) has increased markedly as the world population has aged. Long non-coding RNAs (lncRNAs) have been reported as novel regulators in diverse pathophysiological conditions. Here, we performed RN…

Retraction Note: Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin Open

Steven M. Hill, Eric C. K. Cheng, Lin Yuan, Lulu Mao, Ralf Jockers , et al. · 2024

CAG Repeat Expansions Increase N1-Methyladenine to Alter TDP-43 Phase Separation: Lights Up Therapeutic Intervention for Neurodegeneration Open

Lin Yuan, Lihong Mao, Jiayi Li · 2024

N¹-methyladenine (m¹A), a modification of transcripts, regulates mRNA structure and translation efficiency. In a recent issue of Nature, Sun et al. reported that m¹A in CAG repeat RNA contributes to CAG rep…

MiR‐203 improves cardiac dysfunction by targeting PARP1‐NAD+ axis in aging murine Open

Limin Zhao, Pingping Tang, Lin Yuan, Menghan Du, Huimin Li , et al. · 2023

Heart aging is a prevalent cause of cardiovascular diseases among the elderly. NAD + depletion is a hallmark feature of aging heart, however, the molecular mechanisms that affect NAD + depletion remain unclear. In this study, we identified…

Heterogeneity in Vaccinal Immunity to SARS-CoV-2 Can Be Addressed by a Personalized Booster Strategy Open

Madison Stoddard, Lin Yuan, Sharanya Sarkar, Shruthi Mangalaganesh, Ryan P. Nolan , et al. · 2023

SARS-CoV-2 vaccinations were initially shown to substantially reduce risk of severe disease and death. However, pharmacokinetic (PK) waning and rapid viral evolution degrade neutralizing antibody (nAb) binding titers, causing loss of vacci…

Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice Open

Zi-Lu Ma, Zhangli Wang, Feiyue Zhang, H. P. Liu, Li-Hong Mao , et al. · 2023

Parkinson's disease (PD) is a common neurodegenerative disease characterized pathologically by dopaminergic neuron loss and the formation of Lewy bodies, which are enriched with aggregated α-synuclein (α-syn). PD currently has no cure, but…

Peer Review #1 of "GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (v0.1)" Open

Ming Yang, Xudong Zhu, Yang Shen, Qi He, Yuan Qin , et al. · 2022

Objective: This study aimed to establish a prognostic model related to prostate cancer (PCa) recurrence-free survival (RFS) and identify biomarkers.Methods: The RFS prognostic model and key genes associated with PCa were established using …

Peer Review #1 of "GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (v0.2)" Open

Ming Yang, Xudong Zhu, Yang Shen, Qi He, Yuan Qin , et al. · 2022

Objective: This study aimed to establish a prognostic model related to prostate cancer (PCa) recurrence-free survival (RFS) and identify biomarkers.Methods: The RFS prognostic model and key genes associated with PCa were established using …

GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer Open

Ming Yang, Xudong Zhu, Yang Shen, Qi He, Yuan Qin , et al. · 2022

Objective This study aimed to establish a prognostic model related to prostate cancer (PCa) recurrence-free survival (RFS) and identify biomarkers. Methods The RFS prognostic model and key genes associated with PCa were established using L…

Heterogeneity in vaccinal immunity to SARS-CoV-2 can be addressed by a personalized booster strategy Open

Madison Stoddard, Lin Yuan, Sharanya Sarkar, Shruthi Mangalaganesh, Ryan P. Nolan , et al. · 2022

The ongoing COVID-19 pandemic has placed an unprecedented burden on global health. Crucial for managing this burden, the existing SARS-CoV-2 vaccines have substantially reduced the risk of severe disease and death up to this point. The ind…

Identification of Potential Core Genes for the Rupture of Intracranial Aneurysms by a Bioinformatics Analysis Open

Lin Yuan, Hai-Ying Ma, Yi Wang, Jiang He, Heng-Jian Liu · 2022

Background: Previous studies, using autopsy and angiography, have shown that 3.6–6% of the population have intracranial aneurysms, and the rupture of aneurysm can lead to brain dysfunction or even death in patients. Methods: To explore pot…

Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model Open

Yiqing Lv, Lin Yuan, Yan Sun, Hao-Wen Dou, Ji-Hui Su , et al. · 2022

Ferroptosis in Parkinson’s disease: glia–neuron crosstalk Open

Zhangli Wang, Lin Yuan, Wen Li, Jiayi Li · 2022

Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contribu…

Targeting CD38 in acute myeloid leukemia interferes with leukemia trafficking and induces phagocytosis Open

Meike Farber, Yiyang Chen, Lucas Arnold, Michael Möllmann, Eva Boog-Whiteside , et al. · 2021

Targeting the interaction between leukemic cells and the microenvironment is an appealing approach to enhance the therapeutic efficacy in acute myeloid leukemia (AML). AML infiltration induces a significant release of inflammatory cytokine…

Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment Open

Javier Jarazo, Kyriaki Barmpa, Jennifer Modamio, Cláudia Saraiva, Sònia Sabaté‐Soler , et al. · 2021

Background The etiology of Parkinson's disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and specific gene mutations are contributors to the disease. Biallelic mutations in the phosphatase …

M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway Open

Hang Yin, Lin Chen, Shiqi Piao, Yiru Wang, Zhange Li , et al. · 2021

Using mixed-effects modeling to estimate decay kinetics of response to SARS-CoV-2 infection Open

Dean Bottino, Greg Hather, Lin Yuan, Madison Stoddard, Lin White , et al. · 2021

The duration of natural immunity in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a matter of some debate in the literature at present. For example, in a recent publication characterizing SARS-CoV-2 immunity o…

Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions Open

Di Liu, Jianjun Guo, Ji-Hui Su, Alexander Svanbergsson, Lin Yuan , et al. · 2021

Comparative transcriptome analysis of Alpinia oxyphylla Miq. reveals tissue-specific expression of flavonoid biosynthesis genes Open

Lin Yuan, Kun Pan, Yonghui Li, Bo Yi, Bingmiao Gao · 2021

Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis Open

Hui Zhang, Yuxuan Li, Lin Yuan, Lutian Yao, Jie Yang , et al. · 2021

Objective Osteoporosis is a common metabolic bone disease mainly involving bone remodeling and blood vessels. The current study aimed to explore the suppressive role of interleukin (IL)-35 in nuclear factor kappa-B ligand receptor activato…

Using mixed-effects modeling to estimate decay kinetics of response to SARS-CoV-2 infection Open

Dean Bottino, Greg Hather, Lin Yuan, Marcus F. Stoddard, Laura F. White , et al. · 2021

The duration of natural immunity in response to SARS-CoV-2 is a matter of some debate in the literature at present. For example, in a recent publication characterizing SARS-CoV-2 immunity over time, the authors fit pooled longitudinal data…

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