Lufeng Ding
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View article: High-speed mapping of whole-mouse peripheral nerves at subcellular resolution
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution Open
In contrast to the rapid advancements in mesoscale connectomic mapping of the mammalian brain, similar mapping of the peripheral nervous system has remained challenging due to the body size and complexity. Here, we present a high-speed blo…
View article: Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes
Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes Open
To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium im…
View article: Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes
Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes Open
To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium im…
View article: Preferential subcortical collateral projections of pedunculopontine nucleus-targeting cortical pyramidal neurons revealed by brain-wide single fiber tracing
Preferential subcortical collateral projections of pedunculopontine nucleus-targeting cortical pyramidal neurons revealed by brain-wide single fiber tracing Open
View article: Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice
Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice Open
Corticotropin-releasing factor (CRF) neurons are one of the most densely distributed cell types in the central amygdala (CeA), and are involved in a wide range of behaviors including anxiety and learning. However, the fundamental input cir…
View article: Mapping big brains at subcellular resolution in the era of big data in zoology
Mapping big brains at subcellular resolution in the era of big data in zoology Open
View article: Mapping big brains at subcellular resolution in the era of big data in zoology
Mapping big brains at subcellular resolution in the era of big data in zoology Open
View article: Long-range GABAergic projections from the nucleus of the solitary tract
Long-range GABAergic projections from the nucleus of the solitary tract Open
The nucleus of the solitary tract (NTS) plays a crucial role in integrating peripheral information regarding visceral functions. Glutamate decarboxylase 2 (GAD2) inhibitory neurons are abundant in the NTS, and are known to form local and s…
View article: High-throughput whole-brain mapping of rhesus monkey at micron resolution
High-throughput whole-brain mapping of rhesus monkey at micron resolution Open
Whole-brain mesoscale mapping of primates has been hindered by large brain size and the relatively low throughput of available microscopy methods. Here, we present an integrative approach that combines primate-optimized tissue sectioning a…
View article: Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution
Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution Open
The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits, which is of fundamental importance for neuroscience research. Here, we describe a new microsco…
View article: Corticosterone Signaling and a Lateral Habenula–Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model
Corticosterone Signaling and a Lateral Habenula–Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model Open
Self-injurious behavior (SIB) is commonly observed in patients with neuropsychiatric disorders, as well as in nonclinical populations with stress-related mental-health problems. However, the exact circuitry mechanisms underlying SIB have r…
View article: Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution
Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution Open
We describe a new light-sheet microscopy method for fast, large-scale volumetric imaging. Combining synchronized scanning illumination and oblique imaging over cleared, thick tissue sections in smooth motion, our approach achieves high-spe…