Linhong He
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View article: Structural Optimizations on the Scaffold of 7 <i>H</i> ‐Pyrrolo[2,3‐ <i>d</i> ]Pyrimidine to Develop Potent iNOS Inhibitors With Improved Antiarthritis Activity In Vivo
Structural Optimizations on the Scaffold of 7 <i>H</i> ‐Pyrrolo[2,3‐ <i>d</i> ]Pyrimidine to Develop Potent iNOS Inhibitors With Improved Antiarthritis Activity In Vivo Open
Inducible nitric oxide synthase (iNOS) is an attractive target to develop drugs for the treatment of rheumatoid arthritis (RA), whose overexpression leads to the release of abundant NO. In this study, a series of compounds were designed an…
View article: A Wideband Dielectric Resonator Antenna With Four Dielectric Blocks for Generating Filtering Response
A Wideband Dielectric Resonator Antenna With Four Dielectric Blocks for Generating Filtering Response Open
In this letter, a wideband filtering dielectric resonator antenna is proposed. The antenna consists of a hybrid dielectric block and four dielectric blocks with metal vias. The hybrid dielectric resonator is surrounded by the four dielectr…
View article: FTH1P8 induces and transmits docetaxel resistance by inhibiting ferroptosis in prostate cancer
FTH1P8 induces and transmits docetaxel resistance by inhibiting ferroptosis in prostate cancer Open
Overcoming docetaxel resistance remains a significant challenge in the management of prostate cancer. Previous studies have confirmed a link between ferroptosis and the development of docetaxel resistance. This study revealed that docetaxe…
View article: Research Progress in the Separation of Chemical Components from Essential Oils by High-Speed Countercurrent Chromatography
Research Progress in the Separation of Chemical Components from Essential Oils by High-Speed Countercurrent Chromatography Open
Essential oils (EOs) are vital secondary metabolites in plants. They have garnered substantial attention owing to their distinct flavors and desirable attributes, including potent antioxidant, antibacterial, and antitumor properties. Never…
View article: Association between Dietary Theobromine and Cognitive Function in a Representative American Population: A Cross-Sectional Study
Association between Dietary Theobromine and Cognitive Function in a Representative American Population: A Cross-Sectional Study Open
Daily theobromine intake was associated with cognitive performance in a large nationally representative population. However, further research is needed to corroborate our findings.
View article: Toxigenic potential analysis and fumigation treatment of three Fusarium spp. strains isolated from Fusarium head blight of wheat
Toxigenic potential analysis and fumigation treatment of three Fusarium spp. strains isolated from Fusarium head blight of wheat Open
Fusarium Head Blight (FHB) of wheat and small grain cereals caused by Fusarium graminearum and other Fusarium species is an economically cereal disease worldwide.Fusarium infections results in reduced yields and mycotoxin contamination of …
View article: Erratum: New high-spin structure and possible chirality in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mmultiscripts><mml:mi>In</mml:mi><mml:mprescripts/><mml:none/><mml:mn>109</mml:mn></mml:mmultiscripts></mml:math> [Phys. Rev. C <b>98</b>, 014304 (2018)]
Erratum: New high-spin structure and possible chirality in [Phys. Rev. C <b>98</b>, 014304 (2018)] Open
Received 6 August 2020DOI:https://doi.org/10.1103/PhysRevC.102.069903©2020 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasCollective levelsElectromagnetic transitionsEnergy levels & level densitiesNuclear density fu…
View article: Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis
Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis Open
Janus tyrosine kinase 3 (JAK3) is expressed in lymphoid cells and is involved in the signalling of T cell functions. The development of a selective JAK3 inhibitor has been shown to have a potential benefit in the treatment of autoimmune di…
View article: Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis Open
View article: Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors
Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors Open
View article: Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC
Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC Open
View article: Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening
Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening Open
View article: Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents
Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents Open