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View article: Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts
Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts Open
This study delineates a SPOCD1-centered interaction network between CRC cells and CAFs in colorectal cancer liver metastasis (CRLM), offering novel molecular candidates for therapeutic intervention in CRLM.
View article: Artificial intelligence-powered copilots for precision diagnosis and surgical assessment of histological growth patterns in resectable colorectal liver metastases: a prospective study
Artificial intelligence-powered copilots for precision diagnosis and surgical assessment of histological growth patterns in resectable colorectal liver metastases: a prospective study Open
Background: Colorectal cancer (CRC) is a leading cause of mortality in China, with metastasis significantly contributing to poor outcomes. Histopathological growth patterns (HGPs) in colorectal liver metastasis (CRLM) provide vital prognos…
View article: Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts
Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts Open
Background Liver metastasis is one of the leading causes of death in colorectal cancer (CRC). The interaction between tumor cells and components of the tumor microenvironment (TME) plays an irreplaceable role in promoting cancer cell migra…
View article: Repurposing hydrochlorothiazide (HCTZ) for colorectal cancer: a retrospective and single center study
Repurposing hydrochlorothiazide (HCTZ) for colorectal cancer: a retrospective and single center study Open
Background Anti-hypertensive drugs have been reported to demonstrate anti-inflammatory and anti-angiogenic effects. This study aims to investigate the association between anti-hypertensive drugs and the prognosis of colorectal cancer (CRC)…
View article: Tissue Cadherin 17 (<scp>CDH17</scp>): An Important Prognostic Determinant of Colorectal Cancer Using Digital Image Analysis
Tissue Cadherin 17 (<span>CDH17</span>): An Important Prognostic Determinant of Colorectal Cancer Using Digital Image Analysis Open
Background Colorectal cancer (CRC) is a commonly diagnosed malignancy with significant mortality rates worldwide. The identification of robust prognostic biomarkers for prediction of survival outcomes and recurrence can aid disease managem…
View article: Identification and evaluation of a serum <scp>microRNA</scp> panel to diagnose colorectal cancer patients
Identification and evaluation of a serum <span>microRNA</span> panel to diagnose colorectal cancer patients Open
Screening plays a crucial role in the early detection of colorectal cancer, greatly reducing mortality rates. The objective of this study was to identify a non‐invasive diagnostic method utilizing serum microRNA expression for the diagnosi…
View article: A Four-Gene Panel in Rectal Swab Samples as a Biomarker for Colorectal Cancer Screening
A Four-Gene Panel in Rectal Swab Samples as a Biomarker for Colorectal Cancer Screening Open
Background: The dysregulation of gene expression is one of the key molecular features of colorectal cancer (CRC) development. This study aimed to investigate whether such dysregulation is reflected in rectal swab specimens of CRC patients …
View article: Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells
Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells Open
Background Dendritic cell (DC)-mediated antigen presentation is essential for the priming and activation of tumor-specific T cells. However, few drugs that specifically manipulate DC functions are available. The identification of drugs tar…
View article: Serum microRNA Levels as a Biomarker for Diagnosing Non-Alcoholic Fatty Liver Disease in Chinese Colorectal Polyp Patients
Serum microRNA Levels as a Biomarker for Diagnosing Non-Alcoholic Fatty Liver Disease in Chinese Colorectal Polyp Patients Open
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and its prevalence is increasing worldwide. It is reported that NAFLD is associated with colorectal polyps. Since identifying NAFLD in its early sta…
View article: Editorial: Evolving roles of piRNAs in solid tumors
Editorial: Evolving roles of piRNAs in solid tumors Open
EDITORIAL article Front. Oncol., 11 April 2023Sec. Cancer Genetics Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1178634
View article: High Levels of Tumor miR-187-3p—A Potential Tumor-Suppressor microRNA—Are Correlated with Poor Prognosis in Colorectal Cancer
High Levels of Tumor miR-187-3p—A Potential Tumor-Suppressor microRNA—Are Correlated with Poor Prognosis in Colorectal Cancer Open
Background: The microRNA miR-187-3p plays antitumor roles in a variety of cancers. We and others have previously identified miR-187-3p as a potential tumor suppressor in colorectal cancer (CRC), but there are also reports revealing that hi…
View article: High Expression of a Cancer Stemness-Related Gene, Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is Associated with Poor Prognosis of Colorectal Cancer Patients
High Expression of a Cancer Stemness-Related Gene, Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is Associated with Poor Prognosis of Colorectal Cancer Patients Open
Background: Several studies have demonstrated that the molecular profile of normal tissue adjacent to the tumor (NAT) is prognostic for recurrence in patients with different cancers. This study investigated the clinical significance of CBX…
View article: MiR-509-3p is oncogenic, targets the tumor suppressor PHLPP2, and functions as a novel tumor adjacent normal tissue based prognostic biomarker in colorectal cancer
MiR-509-3p is oncogenic, targets the tumor suppressor PHLPP2, and functions as a novel tumor adjacent normal tissue based prognostic biomarker in colorectal cancer Open
Background Recently the role of microRNAs has been explored immensely as novel regulators and potential biomarkers in several cancers. MiR-509-3p is one such miRNA that has been observed to show a mixed expression in different cancers, whi…
View article: CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling
CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling Open
CD26 has been reported as a marker for colorectal cancer stem cells endowed with tumor-initiating properties and capable of colorectal cancer (CRC) metastasis. In this study, we investigated the functional effect of CD26 on CRC angiogenesi…
View article: Application of droplet digital polymerase chain reaction of plasma methylated septin 9 on detection and early monitoring of colorectal cancer
Application of droplet digital polymerase chain reaction of plasma methylated septin 9 on detection and early monitoring of colorectal cancer Open
Methylated septin 9 (SEPT9) has been approved for non-invasive screening of colorectal cancer (CRC), but data on monitoring of CRC is sparse. Droplet digital polymerase chain reaction (ddPCR), with higher detection precision and simpler qu…
View article: A Pilot Study Investigating the Expression Levels of Pluripotency-Associated Genes in Rectal Swab Samples for Colorectal Polyp and Cancer Diagnosis and Prognosis
A Pilot Study Investigating the Expression Levels of Pluripotency-Associated Genes in Rectal Swab Samples for Colorectal Polyp and Cancer Diagnosis and Prognosis Open
Change in gene expression is inevitable in cancer development. With more studies demonstrating the contributions of cancer stem cells (CSCs) in colorectal cancer (CRC) development, this study is aimed at investigating whether rectal swab s…
View article: Repurposing DPP-4 Inhibitors for Colorectal Cancer: A Retrospective and Single Center Study
Repurposing DPP-4 Inhibitors for Colorectal Cancer: A Retrospective and Single Center Study Open
Background: There have been studies reporting the crucial roles of Dipeptidyl-peptidase 4 (DPP4) in colorectal cancer (CRC) initiation and progression, whereas DPP4-inhibitors are safe Food and Drug Association (FDA)-approved drugs for tre…
View article: Novel molecular targets in hepatocellular carcinoma
Novel molecular targets in hepatocellular carcinoma Open
Globally, hepatocellular carcinoma (HCC) is a leading cause of cancer and cancer-related deaths. The therapeutic efficacy of locoregional and systemic treatment in patients with advanced HCC remains low, which results in a poor prognosis. …
View article: Small RNA Profiling of piRNAs in Colorectal Cancer Identifies Consistent Overexpression of piR-24000 That Correlates Clinically with an Aggressive Disease Phenotype
Small RNA Profiling of piRNAs in Colorectal Cancer Identifies Consistent Overexpression of piR-24000 That Correlates Clinically with an Aggressive Disease Phenotype Open
Piwi-interacting RNAs (piRNAs) represent a novel class of small non-coding RNAs (ncRNAs) that have been shown to have a deregulated expression in several cancers, although their clinical significance in colorectal cancer (CRC) remains uncl…
View article: Linking stemness with colorectal cancer initiation, progression, and therapy
Linking stemness with colorectal cancer initiation, progression, and therapy Open
The discovery of cancer stem cells caused a paradigm shift in the concepts of origin and development of colorectal cancer. Several unresolved questions remain in this field though. Are colorectal cancer stem cells the cause or an effect of…
View article: Additional file 2: of Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients
Additional file 2: of Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients Open
Table S2. Pin1, RhoA and RhoC expressions (fold to actin) in all HCC samples and the patientâ s clinicopathological parameters. (XLSX 25 kb)
View article: Deoxycytidine kinase expression in AML blasts and its relationship to leukemia-free and overall survival
Deoxycytidine kinase expression in AML blasts and its relationship to leukemia-free and overall survival Open
Aim: Study the correlation of expression of genes involved in cytarabine metabolism to leukemia-free (LFS) and overall survival (OS) in AML. Introduction: Cytarabine is the backbone of AML therapy. Understanding the roles and polymorphisms…