Explanipedia

Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson’s disease Open

Luca Ballotto, Thomas Baratta, H Winterberg, Cédric Dusanter, Sara Sambin , et al. · 2025

Neuroinflammation is increasingly recognized as a central pathological mechanism in Parkinson’s disease (PD), a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and variety of motor and non…

Beyond neurons: How does dopamine signaling impact astrocytic functions and pathophysiology? Open

Giulia Favetta, Luigi Bubacco · 2025

Astrocytes, the most abundant glial cells in the central nervous system (CNS), are critical regulators of brain homeostasis and play an active role in synaptic signaling and plasticity. While dopamine, a key catecholamine neurotransmitter,…

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open

Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao, Elena Giusto , et al. · 2024

Immune landscape of the enteric nervous system differentiates Parkinson's disease patients from controls: The PADUA-CESNE cohort Open

Marta Campagnolo, Luca Weis, Michele Sandre, Aleksandar Tushevski, Francesco Paolo Russo , et al. · 2024

These findings broaden our understanding of the mechanisms underlying the enteric nervous system's involvement in PD and point to the gastrointestinal system as a potential therapeutic target, especially in the early stages of the disease.…

Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis Open

Anna Masato, Annapaola Andolfo, Giulia Favetta, Edoardo Bellini, Susanna Cogo , et al. · 2024

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open

Elisa Greggio, Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao , et al. · 2024

P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the phy…

The αSynuclein half-life conundrum Open

Anna Masato, Luigi Bubacco · 2024

αSynuclein (αSyn) misfolding and aggregation frequently precedes neuronal loss associated with Parkinson's Disease (PD) and other Synucleinopathies. The progressive buildup of pathological αSyn species results from alterations on αSyn gene…

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open

Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao, Elena Giusto , et al. · 2024

P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the phy…

Prospective Role of PAK6 and 14-3-3γ as Biomarkers for Parkinson’s Disease Open

Elena Giusto, Lorenza Maistrello, Lucia Iannotta, Veronica Giusti, Ludovica Iovino , et al. · 2024

Background: Parkinson’s disease is a progressive neurodegenerative disorder mainly distinguished by sporadic etiology, although a genetic component is also well established. Variants in the LRRK2 gene are associated with both familiar and …

Correction: Nanorod-associated plasmonic circular dichroism monitors the handedness and composition of α-synuclein fibrils from Parkinson's disease models and post-mortem brain Open

Francesca Longhena, Rihab Boujelbene, Viviana Brembati, Michele Sandre, Luigi Bubacco , et al. · 2024

Correction for ‘Nanorod-associated plasmonic circular dichroism monitors the handedness and composition of α-synuclein fibrils from Parkinson's disease models and post-mortem brain’ by Francesca Longhena et al. , Nanoscale , 2024, 16 , 188…

Neuroprotective Effect of Antiapoptotic URG7 Protein on Human Neuroblastoma Cell Line SH-SY5Y Open

Ilaria Nigro, Rocchina Miglionico, Monica Carmosino, Andrea Gerbino, Anna Masato , et al. · 2023

Up-regulated Gene clone 7 (URG7) is a protein localized in the endoplasmic reticulum (ER) and overexpressed in liver cells upon hepatitis B virus (HBV) infection. Its activity has been related to the attenuation of ER stress resulting from…

Graphical Abstract: Angew. Chem. Int. Ed. 50/2023 Open

Zhonglong Zhao, Jiangwei Zhang, Qin Wang, Limin Wu, Anna Hartmann , et al. · 2023

An s-block potassium

Graphisches Inhaltsverzeichnis: Angew. Chem. 50/2023 Open

Sheng Zhu, X. Dai, Yi Xie, Wei Feng, Y Chen , et al. · 2023

Profiles"Scientific exchange between Salonen and Medina nucleated several years ago during their postdoctoral time in Munich working on covalently connected framework materials… Sharing the excitement about science has been key to maintain…

Site‐Specific Ubiquitination of Tau Amyloids Promoted by the E3 Ligase CHIP Open

Francesca Parolini, Elham Ataie Kachoie, Giulia Leo, Laura Civiero, Luigi Bubacco , et al. · 2023

Post‐translational modifications of Tau are emerging as key players in determining the onset and progression of different tauopathies such as Alzheimer's disease, and are recognized to mediate the structural diversity of the disease‐specif…

Site‐Specific Ubiquitination of Tau Amyloids Promoted by the E3 Ligase CHIP Open

Francesca Parolini, Elham Ataie Kachoie, Giulia Leo, Laura Civiero, Luigi Bubacco , et al. · 2023

Post‐translational modifications of Tau are emerging as key players in determining the onset and progression of different tauopathies such as Alzheimer's disease, and are recognized to mediate the structural diversity of the disease‐specif…

Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s disease Open

Laura Civiero, Elena Giusto, Lorenza Maistrello, Lucia Iannotta, Veronica Giusti , et al. · 2023

Parkinson’s disease (PD) is a progressive neurodegenerative disorder mainly distinguished by sporadic aetiology, although a genetic component is also well established. Variants in the LRRK2 gene are associated with both familiar and sporad…

Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s disease Open

Elena Giusto, Lorenza Maistrello, Lucia Iannotta, Veronica Giusti, Ludovica Iovino , et al. · 2023

2. Abstract Background Parkinson’s disease is a progressive neurodegenerative disorder mainly distinguished by sporadic aetiology, although a genetic component is also well established. Variants in the LRRK2 gene are associated with both f…

DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease Open

Anna Masato, Nicoletta Plotegher, Francesca Terrin, Michele Sandre, Gaia Faustini , et al. · 2023

Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal neuron degeneration in Parkinson’s disease (PD). Several studies in experimental models and postmortem PD patients underlined increasing levels of the do…

Duodenal <span>alpha‐Synuclein</span> Pathology and Enteric Gliosis in Advanced Parkinson's Disease Open

Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garrì , et al. · 2023

Background The role of the gut‐brain axis has been recently highlighted as a major contributor to Parkinson's disease (PD) physiopathology, with numerous studies investigating bidirectional transmission of pathological protein aggregates, …

Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment Open

Chiara Bacchella, Francesca Camponeschi, Paulina Kołkowska, Arian Kola, Isabella Tessari , et al. · 2023

α-Synuclein (αSyn) constitutes the main protein component of Lewy bodies, which are the pathologic hallmark in Parkinson’s disease. αSyn is unstructured in solution but the interaction of αSyn with lipid membrane modulates its conformation…

α-Synuclein Toxicity in Drosophila melanogaster Is Enhanced by the Presence of Iron: Implications for Parkinson’s Disease Open

Francesco Agostini, Luigi Bubacco, Sasanka Chakrabarti, Marco Bisaglia · 2023

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by the preferential loss of dopaminergic neurons and by the accumulation of intracellular inclusions mainly composed of α-synuclein (α-Syn). While…

Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers Open

Emily B. Brady, Molly McQuillan, Audrey T. Medeiros, Luigi Bubacco, Rui Sousa , et al. · 2023

Aberrant buildup of α-synuclein is associated with Parkinson’s disease (PD) and other neurodegenerative disorders. At synapses, α-synuclein accumulation leads to severe synaptic vesicle trafficking defects. We previously demonstrated that …

Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase Open

Elina Buitrago, Clarisse Faure, Marcello Carotti, Elisabetta Bergantino, Renaud Hardré , et al. · 2023

Fluorescence labeling methods influence the aggregation process of α-syn <i>in vitro</i> differently Open

Samira Jadavi, Silvia Dante, Laura Civiero, Michele Sandre, Luigi Bubacco , et al. · 2023

Different labelling strategies adopted to mark α-synuclein affect differently the aggregation of this peptide in vitro . By using super-resolved correlative STED–AFM microscopy we discriminate between fluorescent and non fluorescent aggreg…

Scavenging neurotoxic aldehydes using lysine carbon dots Open

Daniel Nir Bloch, Michele Sandre, Shani Ben Zichri, Anna Masato, Sofiya Kolusheva , et al. · 2023

Reactive neurotoxic aldheyde DOPAL, enzymatically produced from dopamine in cells and tissues, is associated with adverse physiological effects. Lysine-C-dots inhibit DOPAL-induced α-synuclein oligomerization and cytotoxicity.

DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis Open

Federica De Lazzari, Francesco Agostini, Nicoletta Plotegher, Michele Sandre, Elisa Greggio , et al. · 2022

DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster Open

Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro Agostino Zordan , et al. · 2022

Redox homeostasis is a vital process the maintenance of which is assured by the presence of numerous antioxidant small molecules and enzymes and the alteration of which is involved in many pathologies, including several neurodegenerative d…

Duodenal alpha-Synuclein pathology and enteric gliosis in advanced Parkinson’s Disease patients Open

Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garrì , et al. · 2022

Background The role of the gut-brain axis has been recently highlighted as a major contributor to Parkinson’s Disease (PD) physiopathology, with numerous studies investigating bidirectional transmission of pathological protein aggregates, …

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease Open

Ludovica Iovino, Veronica Giusti, Francesca Pischedda, Elena Giusto, Nicoletta Plotegher , et al. · 2022

LRRK2 as a target for modulating immune system responses Open

Isabella Russo, Luigi Bubacco, Elisa Greggio · 2022

Luigi Bubacco YOU? Author Swipe