Luigi De Masi
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View article: Genome Sequencing of a Fusarium Endophytic Isolate from Hazelnut: Phylogenetic and Metabolomic Implications
Genome Sequencing of a Fusarium Endophytic Isolate from Hazelnut: Phylogenetic and Metabolomic Implications Open
This study reports on the whole genome sequencing of the hazelnut endophytic Fusarium isolate Hzn5 from Poland. It was identified as a member of the Fusarium citricola species complex based on a phylogenetic analysis which also pointed out…
View article: Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential Open
Epigallocatechin gallate (EGCG), the predominant catechin in green tea, comprises approximately 50% of its total polyphenol content and has garnered widespread recognition for its significant therapeutic potential. As the principal bioacti…
View article: Coin Circulation in Lipari (Sicily) from the Greek to the Roman Period
Coin Circulation in Lipari (Sicily) from the Greek to the Roman Period Open
View article: Health-Promoting Effects, Phytochemical Constituents and Molecular Genetic Profile of the Purple Carrot ‘Purple Sun’ (Daucus carota L.)
Health-Promoting Effects, Phytochemical Constituents and Molecular Genetic Profile of the Purple Carrot ‘Purple Sun’ (Daucus carota L.) Open
The purple carrot cultivar ‘Purple Sun’ (Daucus carota L.) is characterized by a relevant content of phenolic compounds and anthocyanins, which may play an important role in reducing the risk of chronic diseases and in the treatment of met…
View article: Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions
Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions Open
Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality. These diseases have a multifaceted nature being influenced by a multitude of biochemical, genetic, environmental, and behavioral factors. Epigenetic m…
View article: Analysis of Dieback in a Coastal Pinewood in Campania, Southern Italy, through High-Resolution Remote Sensing
Analysis of Dieback in a Coastal Pinewood in Campania, Southern Italy, through High-Resolution Remote Sensing Open
For some years, the stone pine (Pinus pinea L.) forests of the Domitian coast in Campania, Southern Italy, have been at risk of conservation due to biological adversities. Among these, the pine tortoise scale Toumeyella parvicornis (Cocker…
View article: Functional Properties of Natural Products and Human Health
Functional Properties of Natural Products and Human Health Open
Natural products (NPs), broadly defined as chemicals produced by living organisms including microbes, marine organisms, animals, fungi and plants, are widely used as therapeutic agents for treating diseases and maintaining health and “well…
View article: Sirtuin Inhibitor Cambinol Induces Cell Differentiation and Differently Interferes with SIRT1 and 2 at the Substrate Binding Site
Sirtuin Inhibitor Cambinol Induces Cell Differentiation and Differently Interferes with SIRT1 and 2 at the Substrate Binding Site Open
Epigenetic mechanisms finely regulate gene expression and represent potential therapeutic targets. Cambinol is a synthetic heterocyclic compound that inhibits class III histone deacetylases known as sirtuins (SIRTs). The acetylating action…
View article: Pilot Study on the Geographical Mapping of Genetic Diversity among European Chestnut (Castanea sativa Mill.) Cultivars in Southern Italy
Pilot Study on the Geographical Mapping of Genetic Diversity among European Chestnut (Castanea sativa Mill.) Cultivars in Southern Italy Open
Knowledge of the spatial distribution of European chestnut (Castanea sativa Mill.) cultivar diversity is essential for managing and conserving the genetic resources of this fruit tree species in Southern Italy. To this goal, the present wo…
View article: Molecular Aspects of Spike–ACE2 Interaction
Molecular Aspects of Spike–ACE2 Interaction Open
A new betacoronavirus (CoV-2) is responsible for the pandemic of severe acute respiratory syndrome (SARS) that began in China at the end of 2019, today known as COronaVIrus Disease 2019 (COVID-19). Subsequent studies confirmed the human an…
View article: [Retracted] Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential
[Retracted] Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential Open
Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate ( Punica granatum L.) and in wood and bark of some tree species. Structurally,…
View article: Min-max construction of minimal surfaces with a fixed angle at the boundary
Min-max construction of minimal surfaces with a fixed angle at the boundary Open
We prove the existence of minimal surfaces in a bounded convex subset of $\mathbb R^3$, $\mathcal M$, intersecting the boundary of $\mathcal M$ with a fixed contact angle. The proof is based on a min-max construction in the spirit of Almgr…
View article: Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular Receptor
Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular Receptor Open
An outbreak by a new severe acute respiratory syndrome betacoronavirus (SARS-CoV-2) has spread CoronaVirus Disease 2019 (COVID-19) all over the world. Immediately, following studies have confirmed the human Angiotensin-Converting Enzyme 2 …
View article: Metabolite Profile and In Vitro Beneficial Effects of Black Garlic (Allium sativum L.) Polar Extract
Metabolite Profile and In Vitro Beneficial Effects of Black Garlic (Allium sativum L.) Polar Extract Open
Over the centuries, humans have traditionally used garlic (Allium sativum L.) as a food ingredient (spice) and remedy for many diseases. To confirm this, many extensive studies recognized the therapeutic effects of garlic bulbs. More recen…
View article: Molecular Docking Simulations on Histone Deacetylases (HDAC)-1 and -2 to Investigate the Flavone Binding
Molecular Docking Simulations on Histone Deacetylases (HDAC)-1 and -2 to Investigate the Flavone Binding Open
Histone modifications through acetylation are fundamental for remodelling chromatin and consequently activating gene expression. The imbalance between acetylation and deacetylation activity causes transcriptional dysregulation associated w…
View article: Assessment of allergenic potential in urban forests: a case study of the Royal Park of Portici in Southern Italy
Assessment of allergenic potential in urban forests: a case study of the Royal Park of Portici in Southern Italy Open
In modern cities, the abundance of allergenic plant species has contributed to making less healthy the urban environment, as on-going and direct contact of humans with the urban flora can increase the negative effects on people allergic to…
View article: Single Nucleotide Polymorphisms as Practical Molecular Tools to Support European Chestnut Agrobiodiversity Management
Single Nucleotide Polymorphisms as Practical Molecular Tools to Support European Chestnut Agrobiodiversity Management Open
European chestnut orchards are multifunctional agroforestry systems with a key role in environmental management. Their biodiversity is at risk of erosion and farmers do not have enough tools to protect and valorize traditional ecotypes. In…
View article: Comparative Phytochemical Characterization, Genetic Profile, and Antiproliferative Activity of Polyphenol-Rich Extracts from Pigmented Tubers of Different Solanum tuberosum Varieties
Comparative Phytochemical Characterization, Genetic Profile, and Antiproliferative Activity of Polyphenol-Rich Extracts from Pigmented Tubers of Different Solanum tuberosum Varieties Open
Plants produce a vast array of biomolecules with beneficial effects for human health. In this study, polyphenol and anthocyanin-rich extracts (PAE) from pigmented tubers of Solanum tuberosum L. varieties “Blue Star”, “Magenta Love”, and “D…
View article: The Ancient Neapolitan Sweet Lime and the Calabrian Lemoncetta Locrese Belong to the Same Citrus Species
The Ancient Neapolitan Sweet Lime and the Calabrian Lemoncetta Locrese Belong to the Same Citrus Species Open
“Neapolitan limmo” is an ancient and rare sweet Mediterranean lime, now almost extinct but used until a few decades ago for the production of a fragrant liqueur called the “four citrus fruits”. The objective of this work was to compare, th…
View article: Structure and Ligands Interactions of Citrus Tryptophan Decarboxylase by Molecular Modeling and Docking Simulations
Structure and Ligands Interactions of Citrus Tryptophan Decarboxylase by Molecular Modeling and Docking Simulations Open
In a previous work, we in silico annotated protein sequences of Citrus genus plants as putative tryptophan decarboxylase (pTDC). Here, we investigated the structural properties of Citrus pTDCs by using the TDC sequence of Catharanthus rose…
View article: Experimental Evidence and In Silico Identification of Tryptophan Decarboxylase in Citrus Genus
Experimental Evidence and In Silico Identification of Tryptophan Decarboxylase in Citrus Genus Open
Plant tryptophan decarboxylase (TDC) converts tryptophan into tryptamine, precursor of indolealkylamine alkaloids. The recent finding of tryptamine metabolites in Citrus plants leads to hypothesize the existence of TDC activity in this gen…
View article: Anticancer activities of anthocyanin extract from genotyped Solanum tuberosum L. “Vitelotte”
Anticancer activities of anthocyanin extract from genotyped Solanum tuberosum L. “Vitelotte” Open
The action of anthocyanins contained in the Vitelotte potato (Solanum tuberosum L.) in both breast and haematological cancers were investigated. The biomedical activities of anthocyanin extract derived from the Vitelotte cultivar were dete…