Luigi Guida
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The Effect of Adjunctive Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implant Diseases: Systematic Review and Meta-Analysis Open
Background/Objectives: Peri-implant diseases may occur around osseointegrated implants and lead to implant loss. Treatment strategies focus on infection control with decontamination of implant surfaces/pockets. Mechanical debridement (MD) …
Plasmonic Optical Fibre–Based Point-of-Care Test for Periodontal MIP-1α Detection: A Validation Study of a Multiplexed Biosensor Prototype Open
The novel SPR-POF prototype would be of value for future studies related to POCT devices for monitoring of periodontal health and disease.
View article: Effectiveness of Implant Therapy in Patients With and Without a History of Periodontitis: A Systematic Review With Meta‐Analysis of Prospective Cohort Studies
Effectiveness of Implant Therapy in Patients With and Without a History of Periodontitis: A Systematic Review With Meta‐Analysis of Prospective Cohort Studies Open
Aim This systematic review investigates the effectiveness of implant therapy in patients with and without a history of periodontitis in terms of implant loss, peri‐implant marginal bone loss (MBL), and occurrence of peri‐implant diseases. …
A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection Open
The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon …
View article: Clinical and microbiological efficacy of indocyanine green-based antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of periodontitis: a randomized controlled clinical trial
Clinical and microbiological efficacy of indocyanine green-based antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of periodontitis: a randomized controlled clinical trial Open
Objectives The aim of the present randomized clinical trial (RCT) with a parallel arm design was to evaluate the clinical and microbiological efficacy of repeated ICG-aPDT as an adjunct to full-mouth subgingival debridement in the treatmen…
6 mm short versus 11 mm long inter‐foraminal implants in the full‐arch rehabilitation of edentulous non‐atrophic mandibles: 5‐year results from a multicenter randomized controlled trial Open
Objective The aim of this multicenter parallel‐group randomized controlled trial is to compare, in the same clinical scenario, 6 mm short with 11 mm long implants for the rehabilitation of completely edentulous non‐atrophic mandibles. Mate…
Effects of Magnetic Stimulation on Dental Implant Osseointegration: A Scoping Review Open
This PRISMA-ScR driven scoping review aims to evaluate the influence of magnetic field stimulation on dental implant osseointegration. Seven databases were screened adopting ad-hoc strings. All clinical and preclinical studies analyzing th…
Short versus Longer Implants in Sites without the Need for Bone Augmentation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Objectives: The present systematic review and meta-analysis aims to analyse the clinical performance of short compared to longer implants inserted in sites without the need for bone augmentation. Methods: The protocol of the present PRISMA…
Efficacy of locally delivered statins as an adjunct to scaling and root planning in the treatment of periodontitis: a systematic review and meta-analysis. Open
Within the limits of the available studies, the local administration of statins (in particular, atorvastatin and rosuvastatin) in adjunct to SRP may result in additional significant improvement in terms of CALgain and PDred compared with S…
Bacterial Adhesion to Grade 4 and Grade 5 Turned and Mildly Acid-Etched Titanium Implant Surfaces: An In Vitro and Ex Vivo Study Open
Aim of the present study was to investigate the bacterial adhesion to titanium (Ti) implant surfaces, different for composition and topographic features. Grade 4 and 5 turned (T-4, T-5,) and mildly acid-etched (MA-4, MA-5) Ti 6 × 1 mm disk…
FOXE1-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo Open
Forkhead box E1 (FOXE1) is a lineage-restricted transcription factor involved in thyroid cancer susceptibility. Cancer-associated polymorphisms map in regulatory regions, thus affecting the extent of gene expression. We have recently shown…
The role of bone anabolic drugs in the management of periodontitis: a scoping review Open
The aim of this scoping review was to summarise current knowledge about the effects of bone anabolic drugs on periodontitis, in order to identify new therapeutic strategies for preventing disease progression and reducing tooth loss. A tech…
View article: FOXE1 Gene Dosage Affects Thyroid Cancer Histology and Differentiation In Vivo
FOXE1 Gene Dosage Affects Thyroid Cancer Histology and Differentiation In Vivo Open
The transcription factor Forkhead box E1 (FOXE1) is a key player in thyroid development and function and has been identified by genome-wide association studies as a susceptibility gene for papillary thyroid cancer. Several cancer-associate…
6 mm vs 11 mm implants supporting mandibular full‐arch fixed prostheses: 4‐year ad‐interim report of a multicenter randomized controlled trial Open
Background: The use of short dental implants for the treatment of edentulous atrophic sites has significantly expanded the available options of implant therapy in recent years. The advantages of using short implants (e.g. minimal surgical …
Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review Open
Background and objectives: Periodontitis is a multifactorial chronic inflammatory infectious disease in which an infection is necessary, but not sufficient, for development of the condition. Individual susceptibility strictly linked to the…
Do Dietary Supplements and Nutraceuticals Have Effects on Dental Implant Osseointegration? A Scoping Review Open
Several factors affect dental implant osseointegration, including surgical issues, bone quality and quantity, and host-related factors, such as patients’ nutritional status. Many micronutrients might play a key role in dental implant osseo…
Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice Open
The serine–threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) modulates important cellular functions during development, acting as a signal integrator of a wide variety of stress signals, and as a regulator of transcription …
Enamel Matrix Derivative and Autogenous Bone Graft for Periodontal Regeneration of Intrabony Defects in Humans: A Systematic Review and Meta-Analysis Open
The combination of enamel matrix derivative (EMD) with an autogenous bone graft in periodontal regeneration has been proposed to improve clinical outcomes, especially in case of deep non-contained periodontal defects, with variable results…
The Role of Autologous Platelet Concentrates in Alveolar Socket Preservation: A Systematic Review Open
Prevention of alveolar bone resorption after tooth extraction may be useful for implant rehabilitation of the edentulous site minimizing the future need for bone augmentation procedures. A number of studies have investigated the efficacy o…
The Use of Poly-d,l-lactic Acid (PDLLA) Devices for Bone Augmentation Techniques: A Systematic Review Open
Poly-d,l-lactic acid (PDLLA) has been proposed in dentistry for regenerative procedures in the form of membranes, screws, and pins. The aim of this review was to evaluate the efficacy of bone augmentation techniques using PDLLA devices. A …
Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse Open
lncRNAs are acquiring increasing relevance as regulators in a wide spectrum of biological processes. The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regardin…
Preservation of root cementum: a comparative evaluation of power‐driven versus hand instruments Open
Objectives: The purpose of this study was to evaluate the effects of three distinct periodontal treatment methods in comparison with hand instrumentation on residual cementum of periodontal diseased teeth. Cementum can influence the activi…