Luigi Ippolito
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View article: Mitochondrial ROS inhibition prevents doxorubicin-induced breast cancer cell migration and invasion
Mitochondrial ROS inhibition prevents doxorubicin-induced breast cancer cell migration and invasion Open
View article: Report on the 23rd <scp>FEBS</scp> Young Scientists' Forum 2024
Report on the 23rd <span>FEBS</span> Young Scientists' Forum 2024 Open
The 23rd FEBS YSF was held from 26th to 29th June 2024 in Pavia, Italy. Over 100 PhD students and early postdoctoral researchers from around 30 different countries came together at the inspiring rooms of the University of Pavia for a four‐…
View article: A Comparison Study: Possible Bias in Troponin I Measurement Obtained with a Point of Care Testing and a Central Laboratory Analyzers Employing Different Biological Matrices and Anticoagulants
A Comparison Study: Possible Bias in Troponin I Measurement Obtained with a Point of Care Testing and a Central Laboratory Analyzers Employing Different Biological Matrices and Anticoagulants Open
Background: high-sensitive cardiac TroponinI (hs-cTnI) is widely used for diagnosis of acute coronary syndromes. The latest recommendation for hs-cTnI determination is the protocol 0–1 h finalized to improve the rule out accuracy of the te…
View article: FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer
FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer Open
View article: Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer
Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer Open
Extracellular matrix (ECM) is a major component of the tumor environment, promoting the establishment of a pro-invasive behavior. Such environment is supported by both tumor- and stromal-derived metabolites, particularly lactate. In prosta…
View article: A tribute to Prof. Naranjan S. Dhalla, former Editor-in-Chief of Molecular and Cellular Biochemistry
A tribute to Prof. Naranjan S. Dhalla, former Editor-in-Chief of Molecular and Cellular Biochemistry Open
View article: Acetyl-CoA carboxylase 1 controls a lipid droplet–peroxisome axis and is a vulnerability of endocrine-resistant ER <sup>+</sup> breast cancer
Acetyl-CoA carboxylase 1 controls a lipid droplet–peroxisome axis and is a vulnerability of endocrine-resistant ER <sup>+</sup> breast cancer Open
Targeting aromatase deprives ER + breast cancers of estrogens and is an effective therapeutic approach for these tumors. However, drug resistance is an unmet clinical need. Lipidomic analysis of long-term estrogen-deprived (LTED) ER + brea…
View article: Is SARS-CoV-2 vertical transmission still a current problem? A case report on a diagnosed SARS-CoV-2 infection with a positive sample of urines.
Is SARS-CoV-2 vertical transmission still a current problem? A case report on a diagnosed SARS-CoV-2 infection with a positive sample of urines. Open
The Omicron SARS-CoV-2 keeps provoking infections among newborns, especially if the mother contracts it during the third trimester. The host response is most likely influenced by the newborn's peculiar state of immune immaturity. Just befo…
View article: A new era for Molecular and Cellular Biochemistry
A new era for Molecular and Cellular Biochemistry Open
View article: FADS1/2-mediated lipid metabolic reprogramming drives ferroptosis sensitivity in triple-negative breast cancer
FADS1/2-mediated lipid metabolic reprogramming drives ferroptosis sensitivity in triple-negative breast cancer Open
Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic and characterized by early recurrence. Lipid metabolism is generally deregulated in TNBC and might reveal vulnerabilities to be targeted or used as …
View article: A suspected hypervitaminosis A.
A suspected hypervitaminosis A. Open
We believe that Laboratory testing is one of the most widely used diagnostic interventions supporting medical decisions, and further investigations regarding the etiology and prevalence of this phenomenon are necessary. (www.actabiomedica.…
View article: Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer Open
Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. …
View article: Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer Open
Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. …
View article: Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer Open
Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
View article: Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer Open
Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
View article: Maintainance of diagnostic Laboratory during pandemic emergency (SARS-CoV-2) in a Small Hospital.
Maintainance of diagnostic Laboratory during pandemic emergency (SARS-CoV-2) in a Small Hospital. Open
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View article: Therapeutic support protocol for patient with dysosmia with or without dysgeusia related to the SARS-CoV2 virus infection.
Therapeutic support protocol for patient with dysosmia with or without dysgeusia related to the SARS-CoV2 virus infection. Open
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View article: Metabolic cell communication within tumour microenvironment: models, methods and perspectives
Metabolic cell communication within tumour microenvironment: models, methods and perspectives Open
View article: Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer
Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer Open
View article: Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness
Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness Open
Neoplastic tissues are composed not only by tumor cells but also by several non-transformed stromal cells, such as cancer-associated fibroblasts, endothelial and immune cells, that actively participate to tumor progression. Starting from t…
View article: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer
miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer Open
View article: Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy
Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy Open
Mitochondria play multifaceted roles in malignant tumor progression. Beyond their bioenergetic role, mitochondria are essential for providing malignant cells a higher plasticity to face the harsh environmental conditions. Cell-autonomous m…
View article: Cancer-Associated Fibroblasts Promote Prostate Cancer Malignancy via Metabolic Rewiring and Mitochondrial Transfer
Cancer-Associated Fibroblasts Promote Prostate Cancer Malignancy via Metabolic Rewiring and Mitochondrial Transfer Open
Cancer-associated fibroblasts (CAFs) are the major cellular stromal component of many solid tumors. In prostate cancer (PCa), CAFs establish a metabolic symbiosis with PCa cells, contributing to cancer aggressiveness through lactate shuttl…
View article: Cancer metabolism in space and time: Beyond the Warburg effect
Cancer metabolism in space and time: Beyond the Warburg effect Open
View article: Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells
Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells Open
Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such resistance. Indeed…