Explanipedia

Correction to: ‘Collective rotational motion of freely expanding T84 epithelial cell colonies’ (2023) by Ascione <i>et al.</i> Open

Flora Ascione, Sergio Caserta, Speranza Esposito, Valeria Rachela Villella, Luigi Maiuri , et al. · 2023

Collective rotational motion of freely expanding T84 epithelial cell colonies Open

Flora Ascione, Sergio Caserta, Speranza Esposito, Valeria Rachela Villella, Luigi Maiuri , et al. · 2023

Coordinated rotational motion is an intriguing, yet still elusive mode of collective cell migration, which is relevant in pathological and morphogenetic processes. Most of the studies on this topic have been carried out on epithelial cells…

Collective rotational motion of freely-expanding T84 epithelial cell colonies Open

Flora Ascione, Sergio Caserta, Speranza Esposito, Valeria Rachela Villella, Luigi Maiuri , et al. · 2022

Coordinated rotational motion is an intriguing, yet still elusive mode of collective cell migration, which is relevant in pathological and morphogenetic processes. Most of the studies on this topic have been carried out on confined epithel…

Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy Open

Frank L. van de Veerdonk, Giorgia Renga, Marilena Pariano, Marina Maria Bellet, Giuseppe Servillo , et al. · 2021

Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic stra…

Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosis <i>versus</i> gluten-mediated inhibition in celiac disease Open

Luigi Maiuri, Valeria Raia, Mauro Piacentini, Antonella Tosco, Valeria Rachela Villella , et al. · 2019

Cystic Fibrosis (CF) is the most frequent lethal monogenetic disease affecting humans. CF is characterized by mutations in cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel whose malfunction triggers the activa…

Cystic Fibrosis: New Insights into Therapeutic Approaches Open

Antonella Tosco, Valeria Rachela Villella, Valeria Raia, Guido Kroemer, Luigi Maiuri · 2019

Since the identification of Cystic Fibrosis (CF) as a disease in 1938 until 2012, only therapies to treat symptoms rather than etiological therapies have been used to treat the disease. Over the last few years, new technologies have been d…

Genistein antagonizes gliadin-induced CFTR malfunction in models of celiac disease Open

Speranza Esposito, Valeria Rachela Villella, Eleonora Ferrari, Romina Monzani, Antonella Tosco , et al. · 2019

In celiac disease (CD), an intolerance to dietary gluten/gliadin, antigenic gliadin peptides trigger an HLA-DQ2/DQ8-restricted adaptive Th1 immune response. Epithelial stress, induced by other non-antigenic gliadin peptides, is required fo…

Author Correction: Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux Open

Shaoyi Zhang, Yan Wang, Wei Xie, Ethan N. W. Howe, Nathalie Busschaert , et al. · 2019

In the version of this article originally submitted, it was stated that the first three authors (Shaoyi_ Than, Yan Wang, Wei Xie) had contributed equally. However, in the published version this information was missing.

Congenital Hypopigmentary Disorders with Multiorgan Impairment: A Case Report and an Overview on Gray Hair Syndromes Open

Laura Cristina Gironi, Francesca Zottarelli, Gianfranco Savoldi, Lucia Dora Notarangelo, Maria Eleonora Basso , et al. · 2019

The term congenital hypopigmentary disorders refers to a wide group of heterogeneous hereditary diseases, clinically characterized by inborn pigmentary defects of the iris, hair, and/or skin. They include Gray Hair Syndromes (GHSs), a rare…

The gliadin-CFTR connection: new perspectives for the treatment of celiac disease Open

Luigi Maiuri, Valeria Rachela Villella, Valeria Raia, Guido Kroemer · 2019

Autophagy suppresses the pathogenic immune response to dietary antigens in cystic fibrosis Open

Valeria Rachela Villella, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Antonella Tosco , et al. · 2019

Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux Open

Shaoyi Zhang, Yan Wang, Wei Xie, Ethan N. W. Howe, Nathalie Busschaert , et al. · 2019

Defective proteostasis in celiac disease as a new therapeutic target Open

Luigi Maiuri, Valeria Rachela Villella, Mauro Piacentini, Valeria Raia, Guido Kroemer · 2019

Vitamin D and Type I Diabetes Open

Silvia Savastio, Francesco Cadario, Sheila Beux, Alberto Giorgis, Giulia Genoni , et al. · 2018

Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism but is also endowed with the capability of modulating inflammatory and immune function. Recent studies reported a relationship between low vitamin D levels …

Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease Open

Luigi Maiuri, Guido Kroemer · 2018

Cystic fibrosis (CF) and Wilson disease (WD) are two monogenetic, recessively inherited lethal pathologies that are caused by ionic disequilibria. CF results from loss-of-function mutations in CF transmembrane conductance regulator (CFTR),…

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease Open

Valeria Rachela Villella, Andrea Venerando, Giorgio Cozza, Speranza Esposito, Eleonora Ferrari , et al. · 2018

Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis Open

Luigina Romani, Vasileios Oikonomou, Silvia Moretti, Rossana G. Iannitti, Maria Cristina D’Adamo , et al. · 2018

Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis Open

Luigina Romani, Vasileios Oikonomou, Silvia Moretti, Rossana G. Iannitti, Maria Cristina D’Adamo , et al. · 2018

TG2 regulates the heat‐shock response by the post‐translational modification of HSF1 Open

Federica Rossin, Valeria Rachela Villella, Manuela D’Eletto, Maria Grazia Farrace, Speranza Esposito , et al. · 2018

IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut Open

Giorgia Renga, Silvia Moretti, Vasileios Oikonomou, Monica Borghi, Teresa Zelante , et al. · 2018

Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D Open

Gillian E. Walker, Antonia Follenzi, Valentina Bruscaggin, Marcello Manfredi, Simonetta Bellone , et al. · 2018

Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR Open

Shaoyi Zhang, Gautier Stoll, José Manuel Bravo‐San Pedro, Valentina Sica, Allan Sauvat , et al. · 2018

Cystic Fibrosis (CF) due to the ΔF508 mutation of cystic fibrosis transmembrane conductance regulator (CFTR) can be treated with a combination of cysteamine and Epigallocatechin gallate (EGCG). Since ECGC is not a clinically approved drug,…

IL-9 and Mast Cells Are Key Players of Candida Albicans Commensalism and Pathogenesis in the Gut Open

Giorgia Renga, Silvia Moretti, Vasileios Oikonomou, Monica Borghi, Teresa Zelante , et al. · 2018

Strategies for the etiological therapy of cystic fibrosis Open

Luigi Maiuri, Valeria Raia, Guido Kroemer · 2017

Etiological therapies aim at repairing the underlying cause of cystic fibrosis (CF), which is the functional defect of the cystic fibrosis transmembrane conductance regulator (CFTR) protein owing to mutations in the CFTR gene. Among these,…

The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways Open

Antonella De Luca, Marilena Pariano, Barbara Cellini, Claudio Costantini, Valeria Rachela Villella , et al. · 2017

An ex vivo model contributing to the diagnosis and evaluation of new drugs in cystic fibrosis Open

Antonella Miriam Di Lullo, Manuela Scorza, Felice Amato, Marika Comegna, Valeria Raia , et al. · 2017

La fibrosi cistica (FC) è una malattia autosomica recessiva causata da mutazioni nel gene CFTR (Cystic Fibrosis Transmembrane conductance Regulator). Finora sono state descritte circa 2000 mutazioni, ma per la maggior parte di esse è diffi…

Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis Open

Luigina Romani, Vasileios Oikonomou, Silvia Moretti, Rossana G. Iannitti, Maria Cristina D’Adamo , et al. · 2017

Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation Open

Eleonora Ferrari, Romina Monzani, Valeria Rachela Villella, Speranza Esposito, Francesca Saluzzo , et al. · 2017

Metabolic interactions between cysteamine and epigallocatechin gallate Open

Valentina Izzo, Federico Pietrocola, Valentina Sica, Sylvère Durand, Sylvie Lachkar , et al. · 2017

Phase II clinical trials indicate that the combination of cysteamine plus epigallocatechin gallate (EGCG) is effective against cystic fibrosis in patients bearing the most frequent etiological mutation (CFTRΔF508). Here, we investigated th…

Metabolic interactions between cysteamine and epigallocatechin gallate Open

Valentina Izzo, Federico Pietrocola, Valentina Sica, Sylvère Durand, Sylvie Lachkar , et al. · 2017

Phase II clinical trials indicate that the combination of cysteamine plus epigallocatechin gallate (EGCG) is effective against cystic fibrosis in patients bearing the most frequent etiological mutation (CFTRΔF508). Here, we investigated th…

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