Luis A. Cubano YOU? Author Swipe

Last 10y

Survey of the training needs of genetic assistants supports the creation of genetic assistant training programs Open

Renee Rider, Luis A. Cubano, Ebony Madden, Robb Rowley, Teri A. Manolio · 2023

Despite the increasing numbers of genetic assistants (GAs) in the genomics workforce, their training needs and how to best prepare GAs for their role have not been well defined. We sought to identify the current educational status of GAs, …

Supplemental Tables 1-4 from Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer Open

Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Eliud Hernandez O'Farril, Luis D. Borrero-García, Ingrid Forestier-Román , et al. · 2023

Supplemental Table 1: Effect of MBQ-167 on Rho GTPase activity (Active Rho GTPase/Total Rho GTPase) following 24 h in MDA-MB-231 cells, relative to vehicle (=1); Supplemental Table 2: Effect of MBQ-167 on Rac activity (Active Rac/Total Rac…

Supplemental Figures 1-10 from Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer Open

Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Eliud Hernandez O'Farril, Luis D. Borrero-García, Ingrid Forestier-Román , et al. · 2023

Supplemental Figure 1: Molecular docking of EHop-016 and MBQ-167 into the effector domain of Rac1; Supplemental Figure 2: Cancer cell phenotype following EHop-167 treatment; Supplemental Figure 3: Effect of MBQ-167 on Rac activity of MDA-M…

Supplemental Figures 1-10 from Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer Open

Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Eliud Hernandez O'Farril, Luis D. Borrero-García, Ingrid Forestier-Román , et al. · 2023

Supplemental Figure 1: Molecular docking of EHop-016 and MBQ-167 into the effector domain of Rac1; Supplemental Figure 2: Cancer cell phenotype following EHop-167 treatment; Supplemental Figure 3: Effect of MBQ-167 on Rac activity of MDA-M…

Data from Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer Open

Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Eliud Hernandez O'Farril, Luis D. Borrero-García, Ingrid Forestier-Román , et al. · 2023

The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer malignancy, including cell polarity, migration, and cell-cycle progression. Accord…

Supplemental Tables 1-4 from Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer Open

Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Eliud Hernandez O'Farril, Luis D. Borrero-García, Ingrid Forestier-Román , et al. · 2023

Supplemental Table 1: Effect of MBQ-167 on Rho GTPase activity (Active Rho GTPase/Total Rho GTPase) following 24 h in MDA-MB-231 cells, relative to vehicle (=1); Supplemental Table 2: Effect of MBQ-167 on Rac activity (Active Rac/Total Rac…

Data from Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer Open

Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Eliud Hernandez O'Farril, Luis D. Borrero-García, Ingrid Forestier-Román , et al. · 2023

The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer malignancy, including cell polarity, migration, and cell-cycle progression. Accord…

Development of Competency-based Online Genomic Medicine Training (COGENT) Open

Susanne B. Haga, Wendy K. Chung, Luis A. Cubano, Timothy B. Curry, Philip E. Empey , et al. · 2022

The fields of genetics and genomics have greatly expanded across medicine through the development of new technologies that have revealed genetic contributions to a wide array of traits and diseases. Thus, the development of widely availabl…

Evaluation of the Pink Luminous Breast LED-Based Technology Device as a Screening Tool for the Early Detection of Breast Abnormalities Open

Fernando Ocasio-Villa, Luisa Morales, Norma Velez-Medina, Luis A. Cubano, Juan Carlos Orengo , et al. · 2022

Breast cancer is the leading cause of sex-specific female cancer deaths in the United States. Detection at earlier stages contributes to decreasing the mortality rate. The mammogram is the “Gold Standard” for breast cancer screening with a…

Soy and Frequent Dairy Consumption with Subsequent Equol Production Reveals Decreased Gut Health in a Cohort of Healthy Puerto Rican Women Open

Mercedes Lacourt-Ventura, Brayan Vilanova-Cuevas, Delmarie M. Rivera-Rodríguez, Raysa Rosario-Acevedo, Christine Miranda , et al. · 2021

The U.S. Hispanic female population has one of the highest breast cancer (BC) incidence and mortality rates, while BC is the leading cause of cancer death in Puerto Rican women. Certain foods may predispose to carcinogenesis. Our previous …

<i>Ganoderma lucidum</i>extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway Open

Tiffany J. Rios-Fuller, Gabriela Ortíz-Soto, Mercedes Lacourt-Ventura, Gerónimo Maldonado-Martínez, Luis A. Cubano , et al. · 2018

The aggressive nature of triple negative breast cancer (TNBC) may be explained in part by the presence of breast cancer stem cells (BCSCs), a subpopulation of cells, which are involved in tumor initiation, progression, metastasis, recurren…

Naturally Derived Anti-HIV Polysaccharide Peptide (PSP) Triggers a Toll-Like Receptor 4-Dependent Antiviral Immune Response Open

Madeline Rodríguez-Valentín, Sheila N. López Acevedo, Mariela Rivera, Eddy Ríos‐Olivares, Luis A. Cubano , et al. · 2018

Aim . Intense interest remains in the identification of compounds to reduce human immunodeficiency virus type 1 (HIV-1) replication. Coriolus versicolor ’s polysaccharide peptide (PSP) has been demonstrated to possess immunomodulatory prop…

HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma Open

Sheila N. López Acevedo, Madeline Rodríguez-Valentín, Mariela Rivera, Maridaliz Rodríguez, Mohan Babu , et al. · 2017

HIV-1 clades are known to be one of the key factors implicated in modulating HIV-associated neurocognitive disorders. HIV-1 B and C clades account for the majority of HIV-1 infections, clade B being the most neuropathogenic. The mechanisms…

Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells Open

Mariela Rivera, Yanilda Ramos, Madeline Rodríguez-Valentín, Sheila N. López Acevedo, Luis A. Cubano , et al. · 2017

Curcumin, an extract from the turmeric rhizome (Curcuma longa), is known to exhibit anti-inflammatory, antioxidant, chemopreventive and antitumoral activities against aggressive and recurrent cancers. Accumulative data indicate that curcum…

A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002–2011 Open

Lycely del C. Sepúlveda‐Torres, Lavanya Rishishwar, Maria Luisa Rogers, Eddy Ríos‐Olivares, Nawal M. Boukli , et al. · 2017

Puerto Rico has one of the highest rates of HIV/AIDS seen for any US state or territory, and antiretroviral therapy has been a mainstay of efforts to mitigate the HIV/AIDS public health burden on the island. We studied the evolutionary dyn…

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer Open

Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Eliud Hernandez O'Farril, Luis D. Borrero-García, Ingrid Forestier-Román , et al. · 2017

The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer malignancy, including cell polarity, migration, and cell-cycle progression. Accord…

Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis Open

Lilia Kucheryavykh, Jan Benedikt, Luis A. Cubano, Serguei N. Skatchkov, Feliksas F. Bukauskas , et al. · 2017

Changes in the regulation, formation, and gating of connexin-based gap junction channels occur in various disorders. It has been shown that H and Ca are involved in the regulation of gap junctional communication. Ischemia-induced intracell…

Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis Open

Liza J. Burton, Mariela Rivera, Ohuod Hawsawi, Jin Zou, Tamaro Hudson , et al. · 2016

Muscadine grape skin extract (MSKE) is derived from muscadine grape (Vitis rotundifolia), a common red grape used to produce red wine. Endoplasmic reticulum (ER) stress activates the unfolded protein response (UPR) that serves as a surviva…

Author Index Open

Hugo Adamo, Yolanda Álvarez, B Bagnéris, Edward Baker, Gerd Ulrich Balcke , et al. · 2016

Novel Interactome of<i>Saccharomyces cerevisiae</i>Myosin Type II Identified by a Modified Integrated Membrane Yeast Two-Hybrid (iMYTH) Screen Open

Ednalise Santiago, Pearl Akamine, Jamie Snider, Victoria Wong, Matthew Jessulat , et al. · 2016

Nonmuscle myosin type II (Myo1p) is required for cytokinesis in the budding yeast Saccharomyces cerevisiae. Loss of Myo1p activity has been associated with growth abnormalities and enhanced sensitivity to osmotic stress, making it an appea…

Novel KCNJ10 Gene Variations Compromise Function of Inwardly Rectifying Potassium Channel 4.1 Open

Miguel P. Méndez-González, Yuriy Kucheryavykh, Astrid Zayas‐Santiago, Wanda Velez‐Carrasco, Gerónimo Maldonado-Martínez , et al. · 2016

Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein Open

Columba de la Parra, Linette Castillo‐Pichardo, Ailed Cruz‐Collazo, Luis A. Cubano, Roxana S. Redis , et al. · 2016

We previously reported that dietary genistein inhibits mammary tumor growth and metastasis of the highly metastatic MDA-MB-435 cancer cells in immunocompromised mice. The purpose herein was to characterize the role of the novel oncogenic m…

The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease. Open

Ivette J. Suárez-Arroyo, Yismeilin R. Feliz‐Mosquea, Juliana Pérez-Laspiur, Rezina Arju, Shah Giashuddin , et al. · 2016

Inflammatory Breast Cancer (IBC) is the most lethal form of breast cancer with a 35% 5-year survival rate. The accurate and early diagnosis of IBC and the development of targeted therapy against this deadly disease remain a great medical c…

<i>Ganoderma lucidum</i> Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression Open

Ivette J. Suárez-Arroyo, Tiffany J. Rios-Fuller, Yismeilin R. Feliz‐Mosquea, Mercedes Lacourt-Ventura, Daniel J. Leal-Alviarez , et al. · 2016

The high incidence of resistance to Tyrosine Kinase Inhibitors (TKIs) targeted against EGFR and downstream pathways has increased the necessity to identify agents that may be combined with these therapies to provide a sustained response fo…

Reishi reduces PI3K/AKT/mTOR and MAPK pathway gene and protein expression. Open

Ivette J. Suárez-Arroyo, Raysa Rosario-Acevedo, Alexandra Aguilar‐Perez, Pedro L. Clemente, Luis A. Cubano , et al. · 2015

A. RT² PCR array designed to profile the expression of PI3K/AKT pathway-specific genes was performed using 500 ng of tumor extracted RNA, according to manufacturer’s instructions (SA Biosciences). Volcano plot show effects on ge…

PO133 DIFFERENTIAL EXPRESSION OF PLASMA MEMBRANE PROTEINS IN INFLAMMATORY BREAST CANCER VIA STABLE ISOTOPE LABELED AMINO ACIDS IN CULTURE (SILAC) Open

Michelle Martínez, Ivette J. Suárez-Arroyo, Yismeilin R. Feliz‐Mosquea, Juliana Pérez-Laspiur, Rezina Arju , et al. · 2015

Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico Open

Jannette Gavillán-Suárez, Alexandra Aguilar‐Perez, Natalie Rivera-Ortiz, Karla Rodríguez-Tirado, Wanda M. Figueroa-Cuilan , et al. · 2015

Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway Open

Kimberleve Rolón-Reyes, Yuriy Kucheryavykh, Luis A. Cubano, Mikhail Inyushin, Serguei N. Skatchkov , et al. · 2015

Glioblastoma is one of the most aggressive and fatal brain cancers due to the highly invasive nature of glioma cells. Microglia infiltrate most glioma tumors and, therefore, make up an important component of the glioma microenvironment. In…

Up-Regulation of TREK-2 Potassium Channels in Cultured Astrocytes Requires De Novo Protein Synthesis: Relevance to Localization of TREK-2 Channels in Astrocytes after Transient Cerebral Ischemia Open

Aixa F. Rivera-Pagán, David E. Rivera-Aponte, Katya V. Melnik-Martínez, Astrid Zayas‐Santiago, Lilia Kucheryavykh , et al. · 2015

Excitotoxicity due to glutamate receptor over-activation is one of the key mediators of neuronal death after an ischemic insult. Therefore, a major function of astrocytes is to maintain low extracellular levels of glutamate. The ability of…

Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation Open

Verónica O. Berríos, Nawal M. Boukli, José W. Rodríguez, Priscilla D. Negraes, Telma T. Schwindt , et al. · 2015

Fetching topic information...