Luis Miguel Blanco‐Colio
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View article: High Levels of Galectin-3 and Uric Acid Are Independent Predictors of Renal Impairment in Patients with Stable Coronary Artery Disease
High Levels of Galectin-3 and Uric Acid Are Independent Predictors of Renal Impairment in Patients with Stable Coronary Artery Disease Open
Background: High plasma levels of Galectin-3 (Gal-3) and uric acid (UA) are associated with a decline in renal function in different populations. However, this association has not yet been studied in patients with coronary artery disease (…
View article: Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction
Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction Open
Excessive local inflammation is a common mechanism in many cardiovascular diseases (CVDs) such as hypertension, atherosclerosis and aortic aneurysms. In endothelial cells, inflammatory cytokines such as interferons, tumour necrosis factor …
View article: Annexin A8 deficiency delays atherosclerosis progression
Annexin A8 deficiency delays atherosclerosis progression Open
Background Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids and leukocytes within the arterial wall. By studying the aortic transcriptome of atherosclerosis‐prone apolipoprotein E ( ApoE −/− ) m…
View article: Integrated Stress Response Triggered by Excessive Glycosylation Drives Thoracic Aortic aneurysm
Integrated Stress Response Triggered by Excessive Glycosylation Drives Thoracic Aortic aneurysm Open
Thoracic aortic aneurysms and dissections (TAAD) are marked by degenerative changes in the aortic media. Marfan syndrome is the most common inherited connective tissue disorder associated with TAAD. While vascular smooth muscle cell (VSMC)…
View article: Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury
Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury Open
Spanish Ministry of Science and Innovation, ISCIII and Junta de Andalucía.
View article: Atherosclerosis and Other Related-Arterial Diseases
Atherosclerosis and Other Related-Arterial Diseases Open
Cardiovascular diseases (CVD) are a major cause of morbidity and mortality worldwide, accounting for more than 17 million deaths each year [...]
View article: Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?
Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors? Open
Aortic aneurysms, including abdominal aortic aneurysms (AAAs), is the second most prevalent aortic disease and represents an important cause of death worldwide. AAA is a permanent dilation of the aorta on its infrarenal portion, pathologic…
View article: Absence of High Lipoprotein(a) Levels Is an Independent Predictor of Acute Myocardial Infarction without Coronary Lesions
Absence of High Lipoprotein(a) Levels Is an Independent Predictor of Acute Myocardial Infarction without Coronary Lesions Open
The pathophysiological mechanisms underlying Myocardial Infarction with Non-Obstructive Coronary Artery Disease (MINOCA) are still under debate. Lipoprotein (a) [Lp(a)] has proinflammatory and prothrombotic actions and has been involved in…
View article: Annexins and cardiovascular diseases: Beyond membrane trafficking and repair
Annexins and cardiovascular diseases: Beyond membrane trafficking and repair Open
Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. The main cause underlying CVD is associated with the pathological remodeling of the vascular wall, involving several cell types, including endothelial cells, va…
View article: NT-proBNP Levels Influence the Prognostic Value of Mineral Metabolism Biomarkers in Coronary Artery Disease
NT-proBNP Levels Influence the Prognostic Value of Mineral Metabolism Biomarkers in Coronary Artery Disease Open
Background. Mineral metabolism (MM) system and N-terminal pro-brain natriuretic peptide (NT-ProBNP) have been shown to add prognostic value in patients with stable coronary artery disease (SCAD). However, the influence of NT-ProBNP on the …
View article: Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm
Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm Open
Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside–binding protein, as a therapeutic target for atherosclerosis…
View article: Combined Immunoglobulin Free Light Chains Are Novel Predictors of Cardiovascular Events in Patients With Abdominal Aortic Aneurysm
Combined Immunoglobulin Free Light Chains Are Novel Predictors of Cardiovascular Events in Patients With Abdominal Aortic Aneurysm Open
Increased cFLCs are observed in adventitial tissue of patients with AAA, indicating local activation of B cells. Plasma cFLC levels are an independent predictor of death, MACE, and MALE in patients with AAA.
View article: Role of Extracellular Vesicles as Potential Diagnostic and/or Therapeutic Biomarkers in Chronic Cardiovascular Diseases
Role of Extracellular Vesicles as Potential Diagnostic and/or Therapeutic Biomarkers in Chronic Cardiovascular Diseases Open
Cardiovascular diseases (CVDs) are the first cause of death worldwide. In recent years, there has been great interest in the analysis of extracellular vesicles (EVs), including exosomes and microparticles, as potential mediators of biologi…
View article: N-Terminal Pro-Brain Natriuretic Peptide Plasma Levels Are Associated with Intermediate-Term Follow-Up Cancer in Coronary Patients
N-Terminal Pro-Brain Natriuretic Peptide Plasma Levels Are Associated with Intermediate-Term Follow-Up Cancer in Coronary Patients Open
N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma levels are increased in patients with cancer. In this paper, we test whether NT-proBNP may identify patients who are going to receive a future cancer diagnosis (CD) in the interme…
View article: Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling
Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling Open
Pathological vascular wall remodeling refers to the structural and functional changes of the vessel wall that occur in response to injury that eventually leads to cardiovascular disease (CVD). Vessel wall are composed of two major primary …
View article: Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development
Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development Open
Background Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity. However, the functional role o…
View article: Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease
Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease Open
Inflammation has long been known to play a role in atherogenesis and plaque complication, as well as in some drugs used in therapy for atherosclerotic disease, such as statins, acetylsalicylic acid, and modulators of the renin-angiotensin …
View article: Parathormone levels add prognostic ability to N‐terminal pro‐brain natriuretic peptide in stable coronary patients
Parathormone levels add prognostic ability to N‐terminal pro‐brain natriuretic peptide in stable coronary patients Open
Aims There are controversial data on the ability of the components of mineral metabolism (vitamin D, phosphate, parathormone [PTH], fibroblast growth factor‐23 [FGF23], and klotho) to predict cardiovascular events. In addition, it is unkno…
View article: Endogenous Soluble TRAIL Contributes to the Survival and Growth of Human Mesenchymal Stem Cells
Endogenous Soluble TRAIL Contributes to the Survival and Growth of Human Mesenchymal Stem Cells Open
TNF-related apoptosis-inducing ligand (TRAIL) is known to induce caspase-dependent apoptosis in tumor cells, while sparing normal cells. However, TRAIL is also able to induce proliferation in cells that are resistant to cell death inductio…
View article: MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation
MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation Open
Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of …
View article: N-terminal Pro-brain Natriuretic Peptide plasma levels are Associated With a Short-Term Diagnosis of Cancer in Patients with Coronary Artery Disease
N-terminal Pro-brain Natriuretic Peptide plasma levels are Associated With a Short-Term Diagnosis of Cancer in Patients with Coronary Artery Disease Open
Background N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma levels are increased in patients with cancer. In this paper we test whether NT-proBNP may identify patients who are going to receive a future cancer diagnosis (CD) in t…
View article: Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome
Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome Open
Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association of this with acute atherotrombotic events (AAT). We studie…
View article: CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice
CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice Open
Atherosclerosis is an inflammatory disease characterized by the accumulation of macrophages in the vessel wall. Macrophages depend on their polarization to exert either pro‐inflammatory or anti‐inflammatory effects. Macrophages of the anti…
View article: Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression Open
Recent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic aneurysm (AAA). The study was conducted in plasmas from 39 large size AAA patients (aortic di…
View article: Galectin-3 is Associated with Cardiovascular Events in Post-Acute Coronary Syndrome Patients with Type-2 Diabetes
Galectin-3 is Associated with Cardiovascular Events in Post-Acute Coronary Syndrome Patients with Type-2 Diabetes Open
Introduction: Type-2 diabetes mellitus (T2DM) is associated with early and severe atherosclerosis. However, few biomarkers can predict cardiovascular events in this population. Methods: We followed 964 patients with coronary artery disease…