Luis E. Abatti
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View article: Transcriptional repression of <scp>SOX2</scp> by p53 in cancer cells regulates cell identity and migration
Transcriptional repression of <span>SOX2</span> by p53 in cancer cells regulates cell identity and migration Open
During cancer development and progression, many genetic alterations lead to the acquisition of novel features that confer selective advantage to cancer cells and that resemble developmental programs. SRY‐box transcription factor 2 (SOX2) i…
View article: A role for NFIB in <i>SOX2</i> downregulation and epigenome accessibility changes due to long-term estrogen treatment of breast cancer epithelial cells
A role for NFIB in <i>SOX2</i> downregulation and epigenome accessibility changes due to long-term estrogen treatment of breast cancer epithelial cells Open
Estrogen (E2) regulates the differentiation and proliferation of mammary progenitor cells by modulating the transcription of multiple genes. One of the genes that is downregulated by E2 is SOX2, a transcription factor associated with stem …
View article: Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration Open
During cancer development and progression, many genetic alterations lead to the acquisition of novel features that confer selective advantage to cancer cells and that resemble developmental programs. SOX2 is one of the key pluripotency tra…
View article: Evolution of a novel regulatory mechanism of hypoxia inducible factor in hypoxia-tolerant electric fishes
Evolution of a novel regulatory mechanism of hypoxia inducible factor in hypoxia-tolerant electric fishes Open
Hypoxia is a significant source of metabolic stress that activates many cellular pathways involved in cellular differentiation, proliferation, and cell death. Hypoxia is also a major component in many human diseases and a known driver of m…
View article: Epigenetic reprogramming of a distal developmental enhancer cluster drives <i>SOX2</i> overexpression in breast and lung adenocarcinoma
Epigenetic reprogramming of a distal developmental enhancer cluster drives <i>SOX2</i> overexpression in breast and lung adenocarcinoma Open
Enhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal …
View article: Epigenetic reprogramming of a distal developmental enhancer cluster drives<i>SOX2</i>overexpression in breast and lung cancer
Epigenetic reprogramming of a distal developmental enhancer cluster drives<i>SOX2</i>overexpression in breast and lung cancer Open
Enhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal …
View article: Proof of ChIP selectivity in myometrial tissues.
Proof of ChIP selectivity in myometrial tissues. Open
Applied anti-H3K27ac ChIP in murine myometrial tissue (target, pink) and murine embryonic stem cells (cell control, blue) revealed enrichment or lack of enrichment at select gene targets, as expected. Cell-specific enrichment of this histo…
View article: List of primers used in ChIP-qPCR test.
List of primers used in ChIP-qPCR test. Open
View article: The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice
The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice Open
During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, …
View article: Epigenetic landscapes of select labor-associated genes.
Epigenetic landscapes of select labor-associated genes. Open
UCSC genome browser views of epigenetic and transcription regulatory mark enrichment profiles at (A) Fosl2, (B) Gja1, (C) Oxtr, and (D) Ptgs2. Data displayed include H3K4me3 signal (green), H3K27ac signal (blue)…
View article: List of primers used in RT-qPCR experiments.
List of primers used in RT-qPCR experiments. Open
RT-qPCR, reverse transcriptase-quantitative polymerase chain reaction. (PDF)
View article: Motif enrichment at promoters of labor–up-regulated genes.
Motif enrichment at promoters of labor–up-regulated genes. Open
Motif enrichment at promoters (1 kb upstream of TSS) of genes with increased expression in labor based on intron reads. Data associated with this figure can be found in S6 Data. TSS, transcription start site. (PDF)
View article: Enhancer-gene rewiring in the pathogenesis of Quebec Platelet Disorder
Enhancer-gene rewiring in the pathogenesis of Quebec Platelet Disorder Open
Quebec Platelet Disorder (QPD) is an autosomal dominant bleeding disorder with a unique, platelet-dependent gain-of-function defect in fibrinolysis, without systemic fibrinolysis. The hallmark feature of QPD is a >100-fold overexpressio…
View article: The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice
The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice Open
During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, …
View article: KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control
KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control Open
Embryonic stem (ES) cells are regulated by a network of transcription factors that maintain the pluripotent state. Differentiation relies on down-regulation of pluripotency transcription factors disrupting this network. While investigating…
View article: KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control
KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control Open
Embryonic stem (ES) cells are regulated by a network of transcription factors which maintain the pluripotent state. Differentiation relies on downregulation of pluripotency transcription factors disrupting this network. While investigating…
View article: Regulação da expressão de SOX2 em células-tronco embrionárias e células-tronco induzidas a epiblasto de camundongo
Regulação da expressão de SOX2 em células-tronco embrionárias e células-tronco induzidas a epiblasto de camundongo Open