Luís E. Pablo
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View article: Retinal and Choroidal Morphological Features Influencing Contrast Sensitivity in Retinitis Pigmentosa
Retinal and Choroidal Morphological Features Influencing Contrast Sensitivity in Retinitis Pigmentosa Open
Background and Objectives: To find morphological features on optical coherence tomography (OCT) and OCT-angiography (OCTA) influencing contrast sensitivity (CS) in patients with retinitis pigmentosa (RP). Materials and Methods: Cross-secti…
View article: Effectiveness of Enhanced Modules as a Targeted Intervention to Improve Grade 4 Learners’ Mathematical Competency
Effectiveness of Enhanced Modules as a Targeted Intervention to Improve Grade 4 Learners’ Mathematical Competency Open
Mathematics plays a vital role in developing critical thinking and problem-solving skills. However, many learners, especially in the early grades, struggle with foundational concepts due to the abstract nature of the subject and lack of ta…
View article: Quality indicators to ensure excellence in glaucoma care: the GlauCCare Spanish consensus
Quality indicators to ensure excellence in glaucoma care: the GlauCCare Spanish consensus Open
Topic To develop quality indicators to be included for the certification of excellence care in glaucoma units in Spain. Clinical relevance The certificate of excellence in care in glaucoma units is expected to enhance clinical outcomes and…
View article: Ketorolac, melatonin and latanoprost tri-loaded PLGA microspheres for neuroprotection in glaucoma
Ketorolac, melatonin and latanoprost tri-loaded PLGA microspheres for neuroprotection in glaucoma Open
Glaucoma is a multifactorial neurodegenerative disease that affects the retina and optic nerve. The aim of this work was to reach different therapeutics targets by co-encapsulating three neuroprotective substances with hypotensive (latanop…
View article: Correction: A Preservative-Free Combination of Sodium Hyaluronate and Trehalose Improves Dry Eye Signs and Symptoms and Increases Patient Satisfaction in Real-Life Settings: The TEARS Study
Correction: A Preservative-Free Combination of Sodium Hyaluronate and Trehalose Improves Dry Eye Signs and Symptoms and Increases Patient Satisfaction in Real-Life Settings: The TEARS Study Open
View article: ST Elevation myocardial infarction with split LAD and bilateral acute limb ischemia in young patient with COVID-19
ST Elevation myocardial infarction with split LAD and bilateral acute limb ischemia in young patient with COVID-19 Open
We report a 31-year-old overweight patient without any other cardiovascular risk factors, who presented with a 4-hour ST-segment elevation myocardial infarction (STEMI) with chest pain. An urgent coronary angiogram observed a single corona…
View article: A Preservative-Free Combination of Sodium Hyaluronate and Trehalose Improves Dry Eye Signs and Symptoms and Increases Patient Satisfaction in Real-Life Settings: The TEARS Study
A Preservative-Free Combination of Sodium Hyaluronate and Trehalose Improves Dry Eye Signs and Symptoms and Increases Patient Satisfaction in Real-Life Settings: The TEARS Study Open
NCT04803240.
View article: Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model
Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model Open
This work focused on the co-encapsulation and simultaneous co-delivery of three different neuroprotective drugs in PLGA (poly(lactic-co-glycolic acid) microspheres for the treatment of glaucoma. For formulation optimization, dexamethasone …
View article: A four-years retrospective study: Clinical outcomes of XEN45 in patients with glaucoma
A four-years retrospective study: Clinical outcomes of XEN45 in patients with glaucoma Open
Introduction: To evaluate the long-term effectiveness and safety of XEN45 implant, either alone or in combination with cataract surgery, in patients with glaucoma. Methods: Retrospective and single center study conducted on consecutive pat…
View article: Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model
Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model Open
This work focused on the co-encapsulation and simultaneous co-delivery of three different neuroprotective drugs in PLGA (poly(lactic-co-glycolic acid) microspheres for the treatment of glaucoma. For formulation optimization, dexamethasone …
View article: Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma
Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma Open
Glaucoma is a multifactorial pathology involving the immune system. The subclinical immune response plays a homeostatic role in healthy situations, but in pathological situations, it produces imbalances. Optical coherence tomography detect…
View article: Vision-Related Quality of Life in Patients with Systemic Lupus Erythematosus
Vision-Related Quality of Life in Patients with Systemic Lupus Erythematosus Open
Purpose: To assess vision-related quality of life (VRQoL) in patients with systemic lupus erythematosus (SLE) under treatment with hydroxychloroquine (HCQ), and to find the influencing factors. Methods: Cross-sectional study enrolling SLE …
View article: Corrigendum to “Laponite for biomedical applications: An ophthalmological perspective” [Mater. Today Bio 24 (2024) 100935]
Corrigendum to “Laponite for biomedical applications: An ophthalmological perspective” [Mater. Today Bio 24 (2024) 100935] Open
[This corrects the article DOI: 10.1016/j.mtbio.2023.100935.].
View article: Laponite for biomedical applications: An ophthalmological perspective
Laponite for biomedical applications: An ophthalmological perspective Open
Clay minerals have been applied in biomedicine for thousands of years. Laponite is a nanostructured synthetic clay with the capacity to retain and progressively release drugs. In recent years there has been a resurgence of interest in Lapo…
View article: Chronic Glaucoma Induced in Rats by a Single Injection of Fibronectin-Loaded PLGA Microspheres: IOP-Dependent and IOP-Independent Neurodegeneration
Chronic Glaucoma Induced in Rats by a Single Injection of Fibronectin-Loaded PLGA Microspheres: IOP-Dependent and IOP-Independent Neurodegeneration Open
To evaluate a new animal model of chronic glaucoma induced using a single injection of fibronectin-loaded biodegradable PLGA microspheres (Ms) to test prolonged therapies. 30 rats received a single injection of fibronectin-PLGA-Ms suspensi…
View article: Relationship between treatment and cost with visual acuity improvement in age-related macular degeneration
Relationship between treatment and cost with visual acuity improvement in age-related macular degeneration Open
AntiVEGF treatments (ranibizumab, aflibercept, or both) maintained VA in patients with exudative AMD. Overall, care and treatment costs were lower in the group that received both drugs.
View article: Stargardt pigmentaria: una nueva combinación de 2 distrofias hereditarias de la retina
Stargardt pigmentaria: una nueva combinación de 2 distrofias hereditarias de la retina Open
View article: Efficacy of estimations of Hartmann–Shack sensors in small pupil sizes
Efficacy of estimations of Hartmann–Shack sensors in small pupil sizes Open
PURPOSE: The purpose of this study was to evaluate the in vivo efficacy of the estimations of wavefront analyzers using Hartmann–Shack technology to measure optical aberrations when the pupil size is smaller than the evaluated pupil area. …
View article: Evaluation of multiple sclerosis severity using a new OCT tool
Evaluation of multiple sclerosis severity using a new OCT tool Open
Purpose To assess the ability of a new posterior pole protocol to detect areas with significant differences in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness in patients with multiple sclerosis versus healthy cont…
View article: Efficacy of artificial tears containing trehalose and hyaluronic acid for dry eye disease in women aged 42–54 versus ≥ 55 years
Efficacy of artificial tears containing trehalose and hyaluronic acid for dry eye disease in women aged 42–54 versus ≥ 55 years Open
Artificial tears with trehalose and HA significantly improved the symptoms of DED in women aged 42-54 and ≥ 55 years. The decrease in symptoms was more pronounced in women of age 42-54 years, suggesting better mechanisms of recovery from i…
View article: Charter of Baeza on Agrarian Heritage : Protocol for its updating and implementation at the international level
Charter of Baeza on Agrarian Heritage : Protocol for its updating and implementation at the international level Open
The Charter of Baeza on Agrarian Heritage. It is a document that emerged from the interdisciplinary work of the researchers of the PAGO Project and the participants in the Seminar "Agrarian Heritage: reasons for the cultural recognition of…
View article: Tunable degrees of neurodegeneration in rats based on microsphere-induced models of chronic glaucoma
Tunable degrees of neurodegeneration in rats based on microsphere-induced models of chronic glaucoma Open
View article: Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres
Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres Open
To create a chronic glaucoma animal model by a single intracameral injection of biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (Ms) co-loaded with dexamethasone and fibronectin (MsDexaFibro). MsDexaFibro were prepared by a …
View article: Deep-learning algorithms for choroidal thickness measurements in high myopia
Deep-learning algorithms for choroidal thickness measurements in high myopia Open
View article: Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft
Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft Open
This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery. Patients were…
View article: Analysis of Parainflammation in Chronic Glaucoma Using Vitreous-OCT Imaging
Analysis of Parainflammation in Chronic Glaucoma Using Vitreous-OCT Imaging Open
Glaucoma causes blindness due to the progressive death of retinal ganglion cells. The immune response chronically and subclinically mediates a homeostatic role. In current clinical practice, it is impossible to analyse neuroinflammation no…
View article: Ocular related emergencies in Spain during the COVID-19 pandemic, a multicenter study
Ocular related emergencies in Spain during the COVID-19 pandemic, a multicenter study Open
View article: Influence of Sex on Neuroretinal Degeneration: Six-Month Follow-Up in Rats With Chronic Glaucoma
Influence of Sex on Neuroretinal Degeneration: Six-Month Follow-Up in Rats With Chronic Glaucoma Open
Female rats with chronic glaucoma experienced lower IOP and structural loss and better neuroretinal functionality than males. Sex and the ocular hypertension-inducing method influenced neuroretinal degeneration.
View article: Influence of Chronic Ocular Hypertension on Emmetropia: Refractive, Structural and Functional Study in Two Rat Models
Influence of Chronic Ocular Hypertension on Emmetropia: Refractive, Structural and Functional Study in Two Rat Models Open
Chronic ocular hypertension (OHT) influences on refraction in youth and causes glaucoma in adulthood. However, the origin of the responsible mechanism is unclear. This study analyzes the effect of mild-moderate chronic OHT on refraction an…
View article: Analysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life
Analysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life Open
Patients with FM present with a reduction of the inner retinal layers in the macular area. This degeneration correlates with disease severity/reduced quality of life in these patients. The PPole protocol for OCT is a non-invasive and fast …