Luís F. Callado
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View article: A molecular convergence in the triad of parkinson’s disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis
A molecular convergence in the triad of parkinson’s disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis Open
This study identifies a specific inflammation-miRNA pathway as a common molecular mechanism connecting the pathophysiology of PD, DD, and gut dysfunction. This pattern represents a critical point of convergence that drives a shared, bidire…
View article: Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia
Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with clozapine treatment in schizophrenia Open
View article: Altered immune and inflammatory gene expression in prefrontal cortex of antipsychotic-free schizophrenia subjects
Altered immune and inflammatory gene expression in prefrontal cortex of antipsychotic-free schizophrenia subjects Open
View article: A molecular convergence in the triad of Parkinson's disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis
A molecular convergence in the triad of Parkinson's disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis Open
Background Parkinson's disease (PD) is a multisystem disorder frequently comorbid with non-motor symptoms like depressive disorder (DD) and gastrointestinal (GI) dysfunction. Chronic neuroinflammation and disruption of the gut-brain axis a…
View article: A molecular convergence in the triad of Parkinson’s disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis
A molecular convergence in the triad of Parkinson’s disease, depressive disorder and gut health is revealed by the inflammation-miRNA axis Open
Background Parkinson’s disease (PD) is a multisystem disorder frequently comorbid with non-motor symptoms like depressive disorder (DD) and gastrointestinal (GI) dysfunction. Chronic neuroinflammation and disruption of the gut-brain axis a…
View article: Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex
Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex Open
View article: Extracellular matrix dysfunction and synaptic alterations in schizophrenia
Extracellular matrix dysfunction and synaptic alterations in schizophrenia Open
Schizophrenia is a complex disorder with strong evidence implicating neurodevelopmental abnormalities in its pathophysiology. Olfactory neuroepithelial cells from patients provide a unique platform for studying neurodevelopmental processes…
View article: Regional profiling reveals a distinct glioblastoma infiltrative margin proteome
Regional profiling reveals a distinct glioblastoma infiltrative margin proteome Open
View article: Synthesis of Diversely Substituted Diethyl (Pyrrolidin-2-Yl)Phosphonates
Synthesis of Diversely Substituted Diethyl (Pyrrolidin-2-Yl)Phosphonates Open
Imidazoline I2 receptors (I2-IR) are untapped therapeutic targets lacking a structural description. Although the levels of I2-IR are dysregulated in a plethora of illnesses, the arsenal of ligands that can modulate I2-IR is limited. In thi…
View article: Receptor-mediated Gi-3 activation in mammalian and human brain membranes: Reestablishment method and its application to nociceptin/orphanin FQ opioid peptide (NOP) receptor/Gi-3 interaction
Receptor-mediated Gi-3 activation in mammalian and human brain membranes: Reestablishment method and its application to nociceptin/orphanin FQ opioid peptide (NOP) receptor/Gi-3 interaction Open
Functional activation of heterotrimeric guanine nucleotide-binding proteins (G-proteins) via G-protein-coupled receptors (GPCRs) has been extensively explored using guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS…
View article: Extracellular Matrix Dysfunction Drives Synaptic Pathology in Schizophrenia
Extracellular Matrix Dysfunction Drives Synaptic Pathology in Schizophrenia Open
Schizophrenia is a complex disorder with strong evidence implicating neurodevelopmental abnormalities in its pathophysiology. Olfactory neuroepithelial cells from patients provide a unique platform for studying neurodevelopmental processes…
View article: Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2<i>H</i>-pyrrol-2-yl)phosphonates as Imidazoline <i>I</i><sub>2</sub> Receptor Ligands with Anti-Alzheimer and Analgesic Properties
Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2<i>H</i>-pyrrol-2-yl)phosphonates as Imidazoline <i>I</i><sub>2</sub> Receptor Ligands with Anti-Alzheimer and Analgesic Properties Open
Imidazoline I2 receptors (I2-IRs) are altered in Alzheimer's disease (AD) patients and are associated with analgesia. I2-IRs are not structurally described, and their pharmacological characterization…
View article: Global lncRNA expression profiles in medulloblastoma reveal crucial lncRNA-oncogene interactions in Sonic hedgehog and Group 4
Global lncRNA expression profiles in medulloblastoma reveal crucial lncRNA-oncogene interactions in Sonic hedgehog and Group 4 Open
Background Advances in multi-omic studies have improved medulloblastoma (MB) characterization, yet novel molecular biomarkers are needed to refine tumor biology and therapeutic strategies. Current profiling mainly targets the protein-codin…
View article: Uncovering metabolic dysregulation in schizophrenia and cannabis use disorder through untargeted plasma lipidomics
Uncovering metabolic dysregulation in schizophrenia and cannabis use disorder through untargeted plasma lipidomics Open
Cannabis use disorder affects up to 42% of individuals with schizophrenia, correlating with earlier onset, increased positive symptoms, and more frequent hospitalizations. This study employed an untargeted lipidomics approach to identify b…
View article: CLOZAPINE-RELATED BRAIN<i>NRN1</i>EXPRESSION PATTERNS ARE ASSOCIATED WITH METHYLATION AND GENETIC VARIANTS IN SCHIZOPHRENIA
CLOZAPINE-RELATED BRAIN<i>NRN1</i>EXPRESSION PATTERNS ARE ASSOCIATED WITH METHYLATION AND GENETIC VARIANTS IN SCHIZOPHRENIA Open
The Neuritin-1 gene ( NRN1 ), involved in neurodevelopment and synaptic plasticity, is associated with schizophrenia (SZ) and related clinical, cognitive, and neuroimaging phenotypes. Additionally, it is one of the most differentially meth…
View article: <i>Scn1a</i> haploinsufficiency in the prefrontal cortex leads to cognitive impairment and depressive phenotype
<i>Scn1a</i> haploinsufficiency in the prefrontal cortex leads to cognitive impairment and depressive phenotype Open
Altered development and function of the prefrontal cortex (PFC) during adolescence is implicated in the origin of mental disorders. Deficits in the GABAergic system prominently contribute to these alterations. Nav1.1 is a voltage-gated Na+…
View article: Alcohol Triggers the Accumulation of Oxidatively Damaged Proteins in Neuronal Cells and Tissues
Alcohol Triggers the Accumulation of Oxidatively Damaged Proteins in Neuronal Cells and Tissues Open
Alcohol is toxic to neurons and can trigger alcohol-related brain damage, neuronal loss, and cognitive decline. Neuronal cells may be vulnerable to alcohol toxicity and damage from oxidative stress after differentiation. To consider this f…
View article: NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia
NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia Open
The expression of Neuritin-1 ( NRN1 ), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor ( BDNF ). Although the receptor of NRN1 remains unclear, it is suggeste…
View article: High number of mitochondrial DNA alterations in postmortem brain tissue of patients with schizophrenia compared to healthy controls
High number of mitochondrial DNA alterations in postmortem brain tissue of patients with schizophrenia compared to healthy controls Open
Previous studies have shown mitochondrial dysfunction in schizophrenia (SZ) patients, which may be caused by mitochondrial DNA (mtDNA) alterations. However, there are few studies in SZ that have analyzed mtDNA in brain samples by next-gene…
View article: Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia
Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia Open
Genome-wide association studies have revealed >270 loci associated with schizophrenia risk, yet these genetic factors do not seem to be sufficient to fully explain the molecular determinants behind this psychiatric condition. Epigenetic ma…
View article: Author Response: Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia
Author Response: Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia Open
Genome-wide association studies have revealed >270 loci associated with schizophrenia risk, yet these genetic factors do not seem to be sufficient to fully explain the molecular determinants behind this psychiatric condition. Epigenetic ma…
View article: Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia
Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia Open
Genome-wide association studies have revealed >270 loci associated with schizophrenia risk, yet these genetic factors do not seem to be sufficient to fully explain the molecular determinants behind this psychiatric condition. Epigenetic ma…
View article: Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects
Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects Open
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu 2 R and mGlu 3 R) in brains of schizophrenia patients may explain the limited efficacy of mGlu 2/3 R ligands in clinical trials. Studies ev…
View article: Permissive epigenetic regulatory mechanisms at the histone level are enhanced in postmortem dorsolateral prefrontal cortex of individuals with schizophrenia
Permissive epigenetic regulatory mechanisms at the histone level are enhanced in postmortem dorsolateral prefrontal cortex of individuals with schizophrenia Open
Background: Susceptibility to schizophrenia is determined by interactions between genes and environment, possibly via epigenetic mechanisms. Schizophrenia has been associated with a restrictive epigenome, and histone deacetylase (HDAC) inh…
View article: Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome
Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome Open
Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular communication. The role(s) of these vesicles have been widely investigated in the context of neurological diseases; however, their potential implication…
View article: Gene expression of metabotropic glutamate receptors and histone deacetylases in postmortem prefrontal cortex of subjects with bipolar disorder
Gene expression of metabotropic glutamate receptors and histone deacetylases in postmortem prefrontal cortex of subjects with bipolar disorder Open
View article: Glial and neuronal lesion marker evaluation in schizophrenia-diagnosed patients' plasma
Glial and neuronal lesion marker evaluation in schizophrenia-diagnosed patients' plasma Open
View article: Nrn1 Epistasis With Bdnf and Cacna1c: Mediation Effects on Symptom Severity Through Neuroanatomical Changes in Schizophrenia
Nrn1 Epistasis With Bdnf and Cacna1c: Mediation Effects on Symptom Severity Through Neuroanatomical Changes in Schizophrenia Open
The expression of Neuritin-1 (NRN1), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor (BDNF). Although the receptor of NRN1 remains unclear, it is suggested th…
View article: Transcriptomic hormonal fingerprint in the female offspring of a schizophrenia-like double-hit murine model
Transcriptomic hormonal fingerprint in the female offspring of a schizophrenia-like double-hit murine model Open
View article: Is cognitive performance mediated by anticholinergic medication burden in first episode psychosis?
Is cognitive performance mediated by anticholinergic medication burden in first episode psychosis? Open