Luis F. Lara
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View article: Pancrelipase Treatment of Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: Rationale and Methodology of a Real-World, Prospective, Observational Study
Pancrelipase Treatment of Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: Rationale and Methodology of a Real-World, Prospective, Observational Study Open
View article: Surgical management of congenital sternal cleft in a pediatric patient with PHACES syndrome
Surgical management of congenital sternal cleft in a pediatric patient with PHACES syndrome Open
PHACES syndrome, first described in 1978 and named in 1996, is a rare disorder involving multiple malformations, including abnormalities of the posterior fossa, cervicofacial segmental hemangiomas, cerebrovascular arterial anomalies, cardi…
View article: Association of Hypoalphalipoproteinemia and Its Outcome in Patients Hospitalized in Covid-19 Area at a Tertiary Care Center in Mexico Prior to Vaccination
Association of Hypoalphalipoproteinemia and Its Outcome in Patients Hospitalized in Covid-19 Area at a Tertiary Care Center in Mexico Prior to Vaccination Open
HDL-C has anti-inflammatory properties and low levels are associated with a more severe presentation of COVID-19. Objective: To identify the association of hypoalphalipoproteinemia and outcome in patients hospitalized in the COVID area in …
View article: Prevalence of CFTR Pathogenic Variants in Pancreatitis: A Systematic Review and Meta-Analysis
Prevalence of CFTR Pathogenic Variants in Pancreatitis: A Systematic Review and Meta-Analysis Open
INTRODUCTION: Pathogenic variants (PVs) in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene are commonly reported across the spectrum of pancreatitis, including acute (AP), recurrent acute (RAP), and chronic pancreatit…
View article: Diagnosing COVID-19 Severity from Chest X-Ray Images Using ViT and CNN Architectures
Diagnosing COVID-19 Severity from Chest X-Ray Images Using ViT and CNN Architectures Open
The COVID-19 pandemic strained healthcare resources and prompted discussion about how machine learning can alleviate physician burdens and contribute to diagnosis. Chest x-rays (CXRs) are used for diagnosis of COVID-19, but few studies pre…
View article: The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies
The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies Open
The overall mean liver parameter values were not altered compared to physiological values, except for GGTP, lactate dehydrogenase activity, and INR values. In the case of AST, ALT and albumin levels, mean point estimates were close to limi…
View article: Germline multigene panel testing in acute and chronic pancreatitis
Germline multigene panel testing in acute and chronic pancreatitis Open
Background/Objectives Germline genetic testing is recommended for younger patients with idiopathic pancreatitis but there has been a lack of consensus in recommendations for those over age 35. We aimed to analyze the results of genetic tes…
View article: Addressing the Transition to Adult Health Care for Adolescents and Young Adults with Pancreatic Disorders
Addressing the Transition to Adult Health Care for Adolescents and Young Adults with Pancreatic Disorders Open
To address this gap, we formed a consortium of pancreatic centers that would work in coordination to test interventions to improve the transition for AYA with RAP and CP. We then performed a baseline assessment of consortium resources and …
View article: Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis
Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis Open
Objectives Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipo…
View article: Systemic Neutrophil Gelatinase-Associated Lipocalin Alterations in Chronic Pancreatitis: A Multicenter, Cross-Sectional Study
Systemic Neutrophil Gelatinase-Associated Lipocalin Alterations in Chronic Pancreatitis: A Multicenter, Cross-Sectional Study Open
INTRODUCTION: Chronic pancreatitis (CP) is a progressive fibroinflammatory disorder lacking therapies and biomarkers. Neutrophil gelatinase-associated lipocalin (NGAL) is a proinflammatory cytokine elevated during inflammation that binds f…
View article: The Effect of SARS-CoV-2 Infection on the Level of Liver-Produced Molecules – Systematic Review and Meta-Analysis
The Effect of SARS-CoV-2 Infection on the Level of Liver-Produced Molecules – Systematic Review and Meta-Analysis Open
View article: Intestinal cavernous hemangioma as a cause of anemic syndrome and gastrointestinal bleeding
Intestinal cavernous hemangioma as a cause of anemic syndrome and gastrointestinal bleeding Open
There are multiple causes of non-variceal gastrointestinal bleeding, some more commonly diagnosed than others. Therefore, the finding of a cavernous hemangioma in the jejunum should make us consider patients who present with anemic syndrom…
View article: Acute appendicitis in giant incarcerated umbilical hernia. A Case report
Acute appendicitis in giant incarcerated umbilical hernia. A Case report Open
Umbilical hernias are a frequent reason for patients to visit surgeons. Typically, they are not considered emergencies due to the protrusion of the navel or its sides. However, when the hernia's contents become trapped or strangulated, it …
View article: Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium
Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium Open
View article: Obesity and alcoholic etiology as risk factors for multisystem organ failure in acute pancreatitis: Multinational study
Obesity and alcoholic etiology as risk factors for multisystem organ failure in acute pancreatitis: Multinational study Open
Background Multisystem organ failure (MSOF) is the most important determinant of mortality in acute pancreatitis (AP). Obesity and alcoholic etiology have been examined as potential risk factors for MSOF, but prior studies have not adequat…
View article: Feasibility of single-session endoscopic ultrasound-guided liver biopsy and endoscopic retrograde cholangiopancreatography in liver transplant recipients with abnormal liver function tests
Feasibility of single-session endoscopic ultrasound-guided liver biopsy and endoscopic retrograde cholangiopancreatography in liver transplant recipients with abnormal liver function tests Open
The two most common post-liver transplant (LT) complications include T-cell mediated rejection (TCMR) and biliary pathologies, such as strictures, leaks, and stones/casts. 1Both manifest with abnormal liver function tests (LFTs) with vario…
View article: Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study
Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study Open
Objectives Chronic pancreatitis (CP) is an inflammatory disease that affects the absorption of nutrients like fats. Molecular signaling in pancreatic cells can be influenced by fatty acids (FAs) and changes in FA abundance could impact CP-…
View article: Hepatic Abscess After Pancreatic Extracorporeal Shock Wave Lithotripsy
Hepatic Abscess After Pancreatic Extracorporeal Shock Wave Lithotripsy Open
We report the case of a 61-year-old woman with painful chronic pancreatitis related to proximal pancreatic duct pancreatolithiasis who underwent successful fragmentation with pancreatic extracorporeal shock wave lithotripsy (ESWL). Two wee…
View article: Pediatric-to-Adult Transfer of Care in Patients With Pancreas Disease: Recommendations for Care and Research Opportunities
Pediatric-to-Adult Transfer of Care in Patients With Pancreas Disease: Recommendations for Care and Research Opportunities Open
Young adults who have experienced recurrent acute pancreatitis and chronic pancreatitis as children or adolescents are vulnerable to poor follow-up and disease management during the transfer from the pediatric to adult healthcare system. A…
View article: A Pilot Study to Assess Opportunistic Use of CT-Scan for Osteoporosis Screening in Chronic Pancreatitis
A Pilot Study to Assess Opportunistic Use of CT-Scan for Osteoporosis Screening in Chronic Pancreatitis Open
Objectives: CT scans are commonly performed in patients with chronic pancreatitis (CP). Osteopathy and fractures are recognized in CP but no osteoporosis screening guidelines are recommended. “Opportunistic” CT scan-derived bone density th…
View article: Incidence and Risk Factors for New-Onset Diabetes Mellitus After Surgical Resection of Pancreatic Cystic Lesions
Incidence and Risk Factors for New-Onset Diabetes Mellitus After Surgical Resection of Pancreatic Cystic Lesions Open
Objectives There is a paucity of literature evaluating new-onset diabetes mellitus (NODM) after resection of pancreatic cystic lesions (PCLs). We sought to characterize the incidence and risk factors associated with NODM after partial panc…
View article: Hospital Trends of Acute Pancreatitis During the Coronavirus Disease 2019 Pandemic
Hospital Trends of Acute Pancreatitis During the Coronavirus Disease 2019 Pandemic Open
Objective The coronavirus disease 2019 pandemic led to changes in individuals' behaviors and healthcare delivery. We examined the impact of these changes on the rates and clinical course of acute pancreatitis (AP). Methods Hospitalizations…
View article: Impact of Cannabis Use on Inpatient Inflammatory Bowel Disease Outcomes in 2 States Legalizing Recreational Cannabis
Impact of Cannabis Use on Inpatient Inflammatory Bowel Disease Outcomes in 2 States Legalizing Recreational Cannabis Open
Background We evaluated the impact of recreational cannabis legalization on use and inpatient outcomes of patients with inflammatory bowel disease (IBD). Methods Hospitalized adult patients in Colorado and Washington before (2011) and afte…
View article: Cystic fibrosis patients on cystic fibrosis transmembrane conductance regulator modulators have a reduced incidence of cirrhosis
Cystic fibrosis patients on cystic fibrosis transmembrane conductance regulator modulators have a reduced incidence of cirrhosis Open
CFTR modulators are associated with a reduction in the incidence of cirrhosis compared to other therapies in patients with CF.
View article: Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19
Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19 Open
View article: Cystic Fibrosis Transmembrane Conductance Regulator Modulator Use Is Associated With Reduced Pancreatitis Hospitalizations in Patients With Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator Modulator Use Is Associated With Reduced Pancreatitis Hospitalizations in Patients With Cystic Fibrosis Open
INTRODUCTION: Acute pancreatitis (AP) occurs among patients with pancreas-sufficient cystic fibrosis (PS-CF) but is reportedly less common among patients with pancreas-insufficient cystic fibrosis (PI-CF). The incidence of AP may be influe…
View article: Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT
Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT Open
View article: The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study
The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study Open
View article: The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients With Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation
The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients With Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation Open
Objectives Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. Me…
View article: Identification of a Risk Profile for New-Onset Diabetes After Acute Pancreatitis
Identification of a Risk Profile for New-Onset Diabetes After Acute Pancreatitis Open
Objectives There is a paucity of studies evaluating predictors of new-onset diabetes mellitus (DM) after acute pancreatitis (AP-related DM). We used a population-based database to evaluate predictors of AP-related DM. Methods The Nationwid…