Eduardo L. Franco
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View article: Risk of cancer among individuals with a history of bacterial sexually transmitted infections: A population‐based study in Alberta, Canada
Risk of cancer among individuals with a history of bacterial sexually transmitted infections: A population‐based study in Alberta, Canada Open
We investigated cancer risk among individuals with a prior bacterial sexually transmitted infection (STI) diagnosis using a retrospective cohort study of all Albertan residents diagnosed with chlamydia, gonorrhea, or syphilis during 2000–2…
View article: E6/E7 Similarity to Human Papillomavirus Prototypes and Performance of HPV Testing by Cobas 4800 HPV Test and Anyplex II HPV HR
E6/E7 Similarity to Human Papillomavirus Prototypes and Performance of HPV Testing by Cobas 4800 HPV Test and Anyplex II HPV HR Open
Human papillomavirus (HPV) genotype classification relies on DNA sequence similarity to reference (prototype) sequences. Most HPV assays used for cervical cancer screening were clinically validated against European HPV prototypes. However,…
View article: Epidemiological approaches to evaluate clinical unmasking of <scp>HPV</scp> ‐associated cervical lesions in the <scp>HPV</scp> vaccination era
Epidemiological approaches to evaluate clinical unmasking of <span>HPV</span> ‐associated cervical lesions in the <span>HPV</span> vaccination era Open
HPV vaccination reduces the risk of developing HPV‐attributable cancers, including cervical cancer. However, an attenuation of HPV vaccine impact after the implementation of HPV vaccination may occur through clinical unmasking. Clinical un…
View article: Quadrivalent HPV Vaccine Evaluation Study with Addition of the Nonavalent Vaccine (QUEST-ADVANCE): protocol of an observational cohort study
Quadrivalent HPV Vaccine Evaluation Study with Addition of the Nonavalent Vaccine (QUEST-ADVANCE): protocol of an observational cohort study Open
Introduction The Quadrivalent human papillomavirus (HPV) Vaccine Evaluation Study with Addition of the Nonavalent Vaccine Study (QUEST-ADVANCE) aims to provide insight into the long-term immunogenicity and effectiveness of one, two and thr…
View article: Accelerating HPV-related cancer elimination – a meeting report
Accelerating HPV-related cancer elimination – a meeting report Open
The human papillomavirus (HPV) Prevention and Control Board organized a meeting to explore effective strategies for accelerating the elimination of HPV-related cancers, starting from WHO’s cervical cancer elimination campaign targets—vacci…
View article: Impact of HPV vaccination on the incidence and clearance of HPV infections in sexually active young women
Impact of HPV vaccination on the incidence and clearance of HPV infections in sexually active young women Open
We found that HPV vaccination is effective as a prophylactic measure but has no therapeutic effects on existing infections.
View article: Comparative performance of cobas 4800 HPV Test and Anyplex II HPV HR for high-risk human papillomavirus detection
Comparative performance of cobas 4800 HPV Test and Anyplex II HPV HR for high-risk human papillomavirus detection Open
Numerous molecular tests are available to detect human papillomavirus (HPV). We compared the analytical performance of cobas and Anyplex for detection of high-risk (HR) carcinogenic HPV genotypes, assessed the composition of HPV types (oth…
View article: Application of deep neural networks in the early detection of cervical cancer in digitized cytopathological exams
Application of deep neural networks in the early detection of cervical cancer in digitized cytopathological exams Open
This study evaluates the application of artificial intelligence (AI) in cervical cancer screening, based on the analysis of 2,383 digitized Pap smear images. These images, sourced from 80 clinical cases in municipalities of Amazonas, Brazi…
View article: IgG and IgM Seroreactivity Against Natural HPV16 Infection and <i>HLA‐DRB1</i> and <i>‐DQB1</i> Polymorphism
IgG and IgM Seroreactivity Against Natural HPV16 Infection and <i>HLA‐DRB1</i> and <i>‐DQB1</i> Polymorphism Open
Little is known about the factors associated with the natural humoral immune response against human papillomavirus (HPV) infection. The association between HLA‐DRB1 and ‐DQB1 polymorphism and (1) HPV16 DNA detection, (2) naturally develope…
View article: Table S4 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners
Table S4 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners Open
Oral HPV-level ever-positivity during the study.
View article: Table S1 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners
Table S1 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners Open
Participant characteristics for those with and without anal samples.
View article: Table S2 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners
Table S2 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners Open
HPV-level concordance at the same visit, by visit.
View article: Table S6 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners
Table S6 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners Open
HPV-level associations between selected predictors and HPV ever-positivity in both partners’ genital samples given ever-positivity in one partner’s genital sample.
View article: Data from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners
Data from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners Open
Background:Studying human papillomavirus (HPV) genotype concordance between male and female partners and between multiple anatomic sites can help our understanding of HPV epidemiology.Methods:Heterosexual couples ages 18+ formed within the…
View article: Table S3 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners
Table S3 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners Open
Genital HPV-level ever-positivity during the study.
View article: Table S5 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners
Table S5 from Genital, Oral, and Anal Type-specific Human Papillomavirus Concordance within Individuals and between Partners Open
Anal HPV-level ever-positivity during the study.
View article: Estimating the Age of Disease-causal HPV Infection Based on the Natural History of CIN2+ Among Females in Canada
Estimating the Age of Disease-causal HPV Infection Based on the Natural History of CIN2+ Among Females in Canada Open
Background Although human papillomavirus (HPV) vaccination is approved for males and females up to 45 years of age in Canada, not all of the jurisdictions offer catch-up programs up to age 26. However, US-based modeling studies suggest a s…
View article: Human papillomavirus incidence and transmission by vaccination status among heterosexual couples
Human papillomavirus incidence and transmission by vaccination status among heterosexual couples Open
There was no consistent pattern of protection against incident HPV detection in females and no indication that recent vaccination was associated with lower transmission in discordant couples or with protection for one's partner. Findings s…
View article: Comprehensive appraisal of the association between sexually transmitted infections and prostate cancer: A scoping review of empirical studies, reviews, and meta-analyses
Comprehensive appraisal of the association between sexually transmitted infections and prostate cancer: A scoping review of empirical studies, reviews, and meta-analyses Open
We performed a scoping review on the association of sexually transmitted infections (STIs) with prostate cancer and identified knowledge gaps. Searching four databases (Medline, Embase, Scopus, and Cochrane) identified 286 eligible records…
View article: Inequalities in relative cancer survival by race, immigration status, income, and education for 22 cancer sites in Canada, a cohort study
Inequalities in relative cancer survival by race, immigration status, income, and education for 22 cancer sites in Canada, a cohort study Open
There is a paucity of disaggregated data to monitor cancer health inequalities in Canada. We used data linkage to estimate site‐specific cancer relative survival by race, immigration status, household income, and education level in Canada.…
View article: Social skills and emotional well-being as influenced by their sports involvement among 3-year diploma students
Social skills and emotional well-being as influenced by their sports involvement among 3-year diploma students Open
This study examined how participation in sports affected the social skills and mental health of three-year diploma students at Dumalag Vocational Technical. There were 150 students who were polled using a validated 29-item questionnaire th…
View article: Naturally Acquired Genotype‐Specific HPV Seroreactivity and Subsequent HPV Detection Among Heterosexual Partners
Naturally Acquired Genotype‐Specific HPV Seroreactivity and Subsequent HPV Detection Among Heterosexual Partners Open
The protective effect of naturally acquired humoral immunity against human papillomavirus (HPV) infection remains unclear. To investigate the role of infection‐induced antibodies on HPV detection in heterosexual partners, we used data from…
View article: HPV vaccination and anal HPV infection in gay, bisexual, and other men who have sex with men
HPV vaccination and anal HPV infection in gay, bisexual, and other men who have sex with men Open
Our findings support that HPV vaccination protects against incident anal infection of vaccine-targeted HPV types, thus, gbMSM should be encouraged to get vaccinated against HPV.
View article: A Narrative Review of the Putative Etiologic Role and Diagnostic Utility of the Cervicovaginal Microbiome in Human Papillomavirus‐Associated Cervical Carcinogenesis
A Narrative Review of the Putative Etiologic Role and Diagnostic Utility of the Cervicovaginal Microbiome in Human Papillomavirus‐Associated Cervical Carcinogenesis Open
The cervicovaginal microbiome (CVM) may contribute to human papillomavirus (HPV)‐associated cervical carcinogenesis. We summarized the literature on the CVM in cervical carcinogenesis by searching Medline, Web of Science, and Embase for ar…
View article: Psychological, financial, and educational impacts of the COVID-19 pandemic among children and adolescents with cancer and their families: a systematic review and thematic analysis
Psychological, financial, and educational impacts of the COVID-19 pandemic among children and adolescents with cancer and their families: a systematic review and thematic analysis Open
Children and adolescents diagnosed with cancer and their caregivers are routinely exposed to challenges most families will likely never face, especially during health emergencies where health system resources are put under pressure. The go…