Luis I. Ruffolo
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View article: Rethinking surrogate endpoints in metastatic colorectal cancer: counting chickens only when they hatch
Rethinking surrogate endpoints in metastatic colorectal cancer: counting chickens only when they hatch Open
View article: Evolving concepts in adjuvant/neoadjuvant therapy for resectable pancreas cancer
Evolving concepts in adjuvant/neoadjuvant therapy for resectable pancreas cancer Open
Despite advances in multidisciplinary oncology care, curing patients diagnosed with pancreatic duct adenocarcinoma (PDAC) remains all too uncommon. In this Review, we discuss evolving concepts to guide the care of patients with operable PD…
View article: Corrigendum to ‘The Rochester Protocol for living donor liver transplantation of unresectable colorectal liver metastasis: A 5-year report on selection, approval, and outcomes’ [American Journal of Transplantation 25 (2025) 780–792]
Corrigendum to ‘The Rochester Protocol for living donor liver transplantation of unresectable colorectal liver metastasis: A 5-year report on selection, approval, and outcomes’ [American Journal of Transplantation 25 (2025) 780–792] Open
View article: Outcomes of living donor liver transplant in elevated body mass index over a decade in the United States
Outcomes of living donor liver transplant in elevated body mass index over a decade in the United States Open
View article: Pan-lysyl oxidase inhibition disrupts fibroinflammatory tumor stroma, rendering cholangiocarcinoma susceptible to chemotherapy
Pan-lysyl oxidase inhibition disrupts fibroinflammatory tumor stroma, rendering cholangiocarcinoma susceptible to chemotherapy Open
Background: Cholangiocarcinoma (CCA) features highly desmoplastic stroma that promotes structural and functional resistance to therapy. Lysyl oxidases (LOX, LOXL1–4) catalyze collagen cross-linking, thereby increasing stromal rigidity and …
View article: Transplantation in the Pandemic Era: Perspectives on the Utilization of COVID-19 Positive Organs
Transplantation in the Pandemic Era: Perspectives on the Utilization of COVID-19 Positive Organs Open
Despite new evidence that the transmission of COVID-19 in non-lung organs is extremely rare, the results of this survey suggest significant heterogeneity in practice and perceptions of the use of COVID-19 positive organs across internation…
View article: Drug-Induced p53 Activation Limits Pancreatic Cancer Initiation
Drug-Induced p53 Activation Limits Pancreatic Cancer Initiation Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease, initiated predominantly by mutations in Kras , which induce acinar-to-ductal metaplasia (ADM) and subsequent formation of precursor lesions, such as pancreatic intraepithe…
View article: <i>Smad4</i> restricts injury-provoked biliary proliferation and carcinogenesis
<i>Smad4</i> restricts injury-provoked biliary proliferation and carcinogenesis Open
Cholangiocarcinoma (CCA) is a deadly and heterogeneous type of cancer characterized by a spectrum of epidemiologic associations as well as genetic and epigenetic alterations. We seek to understand how these features inter-relate in the ear…
View article: Comparable and Complimentary Modalities for Treatment of Small-Sized HCC: Surgical Resection, Radiofrequency Ablation, and Microwave Ablation
Comparable and Complimentary Modalities for Treatment of Small-Sized HCC: Surgical Resection, Radiofrequency Ablation, and Microwave Ablation Open
Background: Over the past decade, there has been continual improvement in both ablative and surgical technologies for the treatment of hepatocellular carcinoma (HCC). The efficacy of ablative therapy compared to surgical resection for HCC …
View article: The Current State of Liver Transplantation for Colorectal Liver Metastases in the United States: A Call for Standardized Reporting
The Current State of Liver Transplantation for Colorectal Liver Metastases in the United States: A Call for Standardized Reporting Open
View article: The High Incidence of Occult Carcinoma in Total Hepatectomy Specimens of Patients Treated for Unresectable Colorectal Liver Metastases With Liver Transplant
The High Incidence of Occult Carcinoma in Total Hepatectomy Specimens of Patients Treated for Unresectable Colorectal Liver Metastases With Liver Transplant Open
Objective: To describe the rate of occult carcinoma deposits in total hepatectomy specimens from patients treated with liver transplant (LT) for colorectal liver metastases (CRLM). Background: Previous studies have shown that patients with…
View article: ALPPS and the endless pursuit of hepatic resectability
ALPPS and the endless pursuit of hepatic resectability Open
View article: Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases
Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases Open
Importance Colorectal cancer is a leading cause of cancer-related death, and nearly 70% of patients with this cancer have unresectable colorectal cancer liver metastases (CRLMs). Compared with chemotherapy, liver transplant has been report…
View article: Early postoperative ERAS compliance predicts decreased length of stay and complications following liver resection
Early postoperative ERAS compliance predicts decreased length of stay and complications following liver resection Open
ERAS decreases LOS after liver resection. Nutritional advancement, drain discontinuation, multimodal and oral analgesia, and ambulation >100 ft by POD3 are associated with decreased LOS72. Achieving ≥6 components by POD3 predicts decreased…
View article: In Light of a New Transplant Allocation Policy, Is a LDLT Program Still Justified in a High MELD Region?
In Light of a New Transplant Allocation Policy, Is a LDLT Program Still Justified in a High MELD Region? Open
View article: Socioeconomic Barriers Drive Mortality in Early Stage Hepatocellular Carcinoma
Socioeconomic Barriers Drive Mortality in Early Stage Hepatocellular Carcinoma Open
View article: GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity
GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity Open
Objective Intrahepatic cholangiocarcinoma (iCCA) is rising in incidence, and at present, there are limited effective systemic therapies. iCCA tumours are infiltrated by stromal cells, with high prevalence of suppressive myeloid populations…
View article: Refining the surgical playbook for treating colorectal cancer liver metastases
Refining the surgical playbook for treating colorectal cancer liver metastases Open
View article: Targeting tumor associated macrophages through blockade of GM-CSF sensitizes cholangiocarcinoma to adaptive immunity
Targeting tumor associated macrophages through blockade of GM-CSF sensitizes cholangiocarcinoma to adaptive immunity Open
View article: Table of Contents
Table of Contents Open
View article: Assessing resectability for colorectal liver metastases: agreeing that we disagree
Assessing resectability for colorectal liver metastases: agreeing that we disagree Open
View article: Liver transplantation for colorectal liver metastases: What do we need to know?
Liver transplantation for colorectal liver metastases: What do we need to know? Open
Adenocarcinoma of the colon and rectum (CRC) is the second leading cause of cancer mortality, driven by stage IV disease (Rahib et al., 2014) [1]. While surgical resection of liver metastases has demonstrated a survival advantage, a minori…
View article: Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) procedure for colorectal liver metastasis
Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) procedure for colorectal liver metastasis Open
Since first described, Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has garnered boisterous praise and fervent criticism. Its rapid adoption and employment for a variety of indications resulted in hig…
View article: Septins disruption controls tumor growth and enhances efficacy of Herceptin
Septins disruption controls tumor growth and enhances efficacy of Herceptin Open
Septin expressions are altered in cancer cells and exhibit poor prognoses in malignancies. As the first approach to develop a septin filament targeting agent, we optimized the structure of Forchlorfenuron (FCF), a known plant cytokinin to …
View article: Paraneoplastic syndrome in neuroendocrine breast cancer: A case report
Paraneoplastic syndrome in neuroendocrine breast cancer: A case report Open
Background Paraneoplastic syndromes are rare manifestations of underlying malignancies, most commonly small cell lung cancer and invasive ductal carcinoma of the breast. Case We present a case of anti‐AMPA receptor paraneoplastic limbic en…