Explanipedia

Insight in the Unmet Needs Encountered During the Management of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Open

Jeffrey A. Allen, Helmar C. Lehmann, Eduardo Nobile‐Orazio, Luís Querol, Yusuf A. Rajabally · 2025

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare acquired immune‐mediated disorder affecting peripheral nerves, manifesting most commonly as symmetric, proximal, and distal weakness with sensory loss. Although the…

Relevance of serum neurofilament light chain determination as a biomarker in multiple sclerosis. Consensus of the Spanish Society of Neurology's Study Group on Multiple Sclerosis and Related Neuroimmune Diseases Open

José Manuel García‐Domínguez, Luisa María Villar, Georgina Arrambide, Yolanda Blanco, M. Carmen Calles , et al. · 2025

Treatment Preferences of Neurologists in Generalized Myasthenia Gravis: A Conjoint Analysis Study Open

Luís Querol, Rocío Gómez-Ballesteros, Gerardo Gutiérrez‐Gutiérrez, Ana Núñez Ares, Ramón Villaverde , et al. · 2025

Real‐World Multinational Survey of Chronic Inflammatory Demyelinating Polyneuropathy: Disease Characteristics and Therapeutic Landscape Open

Luís Querol, Simon Rinaldi, András Borsi, Giorgio Maria Boggia, Jonathan de Courcy , et al. · 2025

Background and Aims Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune‐mediated syndrome characterized by progressive muscle weakness and sensory impairment. Clinical similarities with other neuropathies can cause misdia…

B Cell Tolerance and BCR Signaling Dysregulation in NF155-Mediated Autoimmune Nodopathies Open

Bhaskar Roy, Abeer Obaid, Z Wang, Kristof Kovacs, Sarah Ohashi , et al. · 2025

Objective: Autoimmune nodopathies (AINs) are a group of rare, acquired autoimmune neuropathies with distinct clinical features and the presence of circulating autoantibodies - often of the immunoglobulin G4 (IgG4) subclass - targeting prot…

Digital biomechanical assessment of gait in patients with peripheral neuropathies Open

Clara Tejada‐Illa, Jordi Pegueroles, Mireia Claramunt-Molet, Ariadna Pi-Cervera, Ainhoa Heras-Delgado , et al. · 2025

Background The clinical status and treatment response of patients with peripheral neuropathies (PNs) rely on subjective and inaccurate clinical scales. Wearable sensors have been evaluated successfully in other neurological conditions to s…

P.033 Long-term efficacy of Efgartigimod PH20 SC in patients with chronic inflammatory demyelinating polyneuropathy: interim results from the ADHERE+ study Open

JA Allen, Jiunn-Chang Lin, Mark Stettner, Jeff Guptill, Kelly Gwathmey , et al. · 2025

Background: Efgartigimod, a human immunoglobulin (Ig)G1 antibody Fc fragment, blocks the neonatal Fc receptor, reducing IgGs involved in chronic inflammatory demyelinating polyneuropathy (CIDP). The multi-stage, double-blinded, placebo-con…

D.7 Efgartigimod impact on I-RODS daily activity assessment in chronic inflammatory demyelinating polyneuropathy: post hoc analysis of Registrational ADHERE Study Open

JA Allen, Jie Lin, Mark Stettner, Ingemar S.J. Merkies, Jeff Guptill , et al. · 2025

Background: Efgartigimod, a human immunoglobulin (Ig)G1 antibody Fc fragment, blocks the neonatal Fc receptor, reducing IgGs involved in chronic inflammatory demyelinating polyneuropathy (CIDP), a rare, progressive, immune-mediated disease…

Assessing therapeutic decisions in generalized myasthenia gravis: Study protocol Open

Gerardo Gutiérrez‐Gutiérrez, Rocío Gómez-Ballesteros, Javier Sotoca, Ana Núñez Ares, Ramón Villaverde , et al. · 2025

Background The therapeutic landscape in generalized myasthenia gravis (gMG) has been continuously evolving in recent years, with over five products approved, each with different efficacy, safety, and administration profiles. With the avail…

A pathophysiological and mechanistic review of chronic inflammatory demyelinating polyradiculoneuropathy therapy Open

Marta Caballero‐Ávila, L. Aguilar, Roger Collet‐Vidiella, Luís Querol, Elba Pascual‐Goñi · 2025

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disease of the peripheral nerves characterized by proximal and distal muscle weakness and sensory abnormalities. CIDP has been associated with various p…

Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome Open

Robin C.M. Thomma, Susan K. Halstead, L.C. de Koning, Evelin E J A Wiegers, Dawn Gourlay , et al. · 2025

Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside antibodies are thought to …

Attitudes of Neurologists Toward Serum Neurofilament Light-Chain Testing in the Management of Relapsing–Remitting Multiple Sclerosis with Cognitive Impairment Open

José Manuel García‐Domínguez, Jorge Mauriño, José Meca-Lallana, Lamberto Landete, Virginia Meca‐Lallana , et al. · 2025

Background: Cognitive impairment has an impact upon the function and quality of life of patients with multiple sclerosis (MS). High-serum neurofilament light-chain (sNfL) levels predict disease progression and are also associated with impa…

Reply to “Letter to the Editor: Pitfalls in Calculating the Incidence of <span>GBS</span> During the Pandemic” Open

L. Aguilar, Luís Querol · 2025

Inter‐Laboratory Validation of Nodal/Paranodal Antibody Testing Open

Cinta Lleixà, Maarten J. Titulaer, Sophia Rohrbacher, Victor Mgbachi, Susan K. Halstead , et al. · 2025

Background and Aims Reliable detection of antibodies against nodal targets is vital for the diagnosis of autoimmune nodopathies. The performance characteristics of recently developed in‐house assays are unknown. We compared testing at four…

Neural Synaptic Vesicle Autoimmunity Following Occupational Exposure to Aerosolized Porcine Neural Tissue: Etiologic and Immunopathogenic Insights into Autoimmune Inflammatory Polyradiculoneuropathy Open

Shannon R. Hinson, Pranjal Gupta, Naveen Kumar Paramasivan, P. James B. Dyck, Vanda A. Lennon , et al. · 2025

The Discovery of Autoimmune Nodopathies and the Impact of IgG4 Antibodies in Autoimmune Neurology Open

Luís Querol, Marinos C. Dalakas · 2024

In the past decade, significant progress has been made on the understanding of IgG4-mediated autoimmune diseases, of both the central and the peripheral CNS. In addition to the description of diverse antigenic targets, the description of I…

Persistent symptoms, exacerbations and drug side effects despite treatment in myasthenia gravis Open

David Reyes‐Leiva, Álvaro Carbayo, Ana Vesperinas‐Castro, Ricard Rojas‐García, Luís Querol , et al. · 2024

Background Generalized myasthenia gravis (gMG) is characterized by fluctuating muscle weakness. Exacerbation frequency, adverse events (AEs) related to immunosuppressant therapy and healthcare resource utilization (HCRU) are not well under…

Long‐Term Follow Up in Anti‐Contactin‐1 Autoimmune Nodopathy Open

Marta Caballero‐Ávila, L. Aguilar, Elba Pascual‐Goñi, Milou R. Michael, Marleen J.A. Koel‐Simmelink , et al. · 2024

Objective To analyze long‐term clinical and biomarker features of anti‐contactin‐1 (CNTN1) autoimmune nodopathy (AN). Methods Patients with anti‐CNTN1 + autoimmune nodopathy detected in our laboratory from which clinical information was av…

20413. ANÁLISIS LONGITUDINAL DE LA MARCHA MEDIANTE SENSORES BIOMECÁNICOS PORTÁTILES PARA DETECTAR CAMBIOS CLÍNICAMENTE SIGNIFICATIVOS EN PACIENTES CON NEUROPATÍAS PERIFÉRICAS Open

C. Tejada Illa, Jordi Pegueroles, Mireia Claramunt Molet, Alou Cervera, Alvaro Delgado , et al. · 2024

20332. ENSAYO CLÍNICO FASE 2 DE RILIPRUBART EN LA POLINEUROPATÍA DESMIELINIZANTE INFLAMATORIA CRÓNICA (CIDP): FATIGA Y CALIDAD DE VIDA Open

Miguel Alonso‐Alonso, P. van Doorn, Luís Querol, Hans‐Peter Hartung, Richard A. Hughes , et al. · 2024

20390. ENSAYO CLÍNICO FASE 2 DE RILIPRUBART EN CIDP: RESULTADOS PRELIMINARES DE BIOMARCADORES DEL COMPLEMENTO Y NEUROFILAMENTOS DE CADENA LIGERA (NFL) Open

M. Alonso Alonso, Luís Querol, Ruth Lewis, P. van Doorn, R. Hughes , et al. · 2024

20252. ESTUDIO MULTICÉNTRICO SOBRE LA INCIDENCIA, PRESENTACIÓN CLÍNICA Y FACTORES DE RIESGO DE LA NEUROTOXICIDAD ASOCIADA A LA TERAPIA CON CÉLULAS CART ANTI-CD19 EN ESPAÑA: WORK IN PROGRESS Open

Jerónimo Maqueda, E. Fonseca, V. Guerra, T. Alba-Isasi, Núria Martínez‐Cibrian , et al. · 2024

20356. CONTROL ADECUADO DE LA MIASTENIA GRAVIS GENERALIZADA DURANTE UN PERIODO DE 8 AÑOS EN UNA UNIDAD DE REFERENCIA Open

D. Reyes Leiva, Ana Viejo, Arminda Castro, Luís Querol, Marta Rodríguez , et al. · 2024

Inflammatory Neuropathy Consortium base (INCbase): a protocol of a global prospective observational cohort study for the development of a prediction model for treatment response in chronic inflammatory demyelinating polyneuropathy Open

Milou R. Michael, Luuk Wieske, Jeffrey A. Allen, Michael P. Lunn, Kathrin Doppler , et al. · 2024

Background INCbase is an international, multicenter prospective observational study using a customizable web-based modular registry to study the clinical, biological and electrophysiological variation and boundaries of chronic inflammatory…

Digital biomechanical biomarkers in the clinical assessment of patients with peripheral neuropathies Open

Clara Tejada‐Illa, Jordi Pegueroles, Mireia Claramunt-Molet, Ariadna Pi-Cervera, Ainhoa Heras-Delgado , et al. · 2024

The clinical status and treatment response of patients with peripheral neuropathies (PN) rely on subjective and inaccurate clinical scales. Wearable sensors have shown success in evaluating gait and balance in individuals with other neurol…

Modified radioimmunoassay versus ELISA to quantify anti-acetylcholine receptor antibodies in a mouse model of myasthenia gravis Open

Anaís Mariscal, Carmen Martı́nez, Lea Goethals, Elena Cortés‐Vicente, Elisabeth Moltó , et al. · 2024

A nationwide Guillain–Barré syndrome epidemiological study in Spain during the <span>COVID</span> ‐19 years Open

Marina Blanco‐Ruiz, L. Aguilar, Marta Caballero‐Ávila, Cinta Lleixà, Elba Pascual‐Goñi , et al. · 2024

Background and purpose The purpose was to perform a nationwide epidemiological study of Guillain–Barré syndrome (GBS) in Spain, analysing background incidences and seasonal variation and trying to identify incidence changes during the coro…

Absence of Pathogenic Mutations and Strong Association With HLA-DRB1*11:01 in Statin-Naïve Early-Onset Anti-HMGCR Necrotizing Myopathy Open

Laura Llansó, Alba Segarra‐Casas, Cristina Domínguez‐González, Edoardo Malfatti, Solange Kapetanovic , et al. · 2024

WES of a cohort of patients with dystrophy-like anti-HMGCR IMNM did not reveal any common rare variants of any gene, including cholesterol biosynthesis-related genes. HLA analysis showed a strong association with HLA-DRB1*11:01, previously…

Antibodies in Autoimmune Neuropathies Open

Elba Pascual‐Goñi, Marta Caballero‐Ávila, Luís Querol · 2024

Autoimmune neuropathies are a heterogeneous group of immune-mediated disorders of the peripheral nerves. Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are the archetypal acute and chroni…

Long term follow-up in anti-contactin-1 autoimmune nodopathy Open

Marta Caballero‐Ávila, L. Aguilar, Elba Pascual‐Goñi, Milou R. Michael, Marleen J.A. Koel-Simmelink , et al. · 2024

Objective To analyze long-term clinical and biomarker features of anti-contactin-1 (CNTN1) autoimmune nodopathy (AN). Methods Patients with anti-CNTN1+ AN detected in our laboratory from which clinical information was available were includ…

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