Sergio L. Vargas
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View article: Wellens Syndrome: The “Chameleon” in the Electrocardiographic Diagnosis of Coronary Syndrome. Case Report
Wellens Syndrome: The “Chameleon” in the Electrocardiographic Diagnosis of Coronary Syndrome. Case Report Open
Objective: To describe the electrocardiographic characteristics and clinical relevance of Wellens syndrome, a condition associated with critical proximal stenosis of the anterior descending artery, through a clinical case. Material and Met…
View article: 166. A Phase 2b/3 Study to Evaluate the Efficacy and Safety of an Investigational Respiratory Syncytial Virus (RSV) Antibody, Clesrovimab, in Healthy Preterm and Full-Term Infants
166. A Phase 2b/3 Study to Evaluate the Efficacy and Safety of an Investigational Respiratory Syncytial Virus (RSV) Antibody, Clesrovimab, in Healthy Preterm and Full-Term Infants Open
Background Clesrovimab is an investigational, long-acting monoclonal antibody (mAb) targeting site IV of the fusion protein for the prevention of RSV lower respiratory tract infection in infants. Methods This phase 2b/3 double-blind, rando…
View article: Efficacy, Safety, and Immunogenicity of the MATISSE (Maternal Immunization Study for Safety and Efficacy) Maternal Respiratory Syncytial Virus Prefusion F Protein Vaccine Trial
Efficacy, Safety, and Immunogenicity of the MATISSE (Maternal Immunization Study for Safety and Efficacy) Maternal Respiratory Syncytial Virus Prefusion F Protein Vaccine Trial Open
OBJECTIVE: To evaluate descriptive efficacy data, exploratory immunogenicity data, and safety follow-up through study completion from the global, phase 3 MATISSE (Maternal Immunization Study for Safety and Efficacy) maternal vaccination tr…
View article: Pneumocystis sp. is a pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly
Pneumocystis sp. is a pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly Open
Background. Early life gut microbiota is being increasingly recognized as a major contributor to short and/or long-term human health and diseases. However, little is known about these early-life events in the human microbiome of the lower …
View article: Immigration and C-sections incidence: Maternal care and perinatal outcomes in the context of the pandemic in Chile
Immigration and C-sections incidence: Maternal care and perinatal outcomes in the context of the pandemic in Chile Open
Introduction Immigration has increased significantly in Chile. Despite that all pregnant women, regardless of nationality and immigration status, have the right to access to all healthcare services during pregnancy, childbirth, and postpar…
View article: Variability in low Mars atmosphere's H$_2$O concentration stimulated by solar cycle activity
Variability in low Mars atmosphere's H$_2$O concentration stimulated by solar cycle activity Open
Mars' thin, CO$_2$-rich atmosphere poses a unique puzzle involving composition, climate history, and habitability. This work explores the intrincate relationship between Mars' atmospheric variations and dynamic solar activity patterns. We …
View article: Pneumocystis Exacerbates Inflammation and Mucus Hypersecretion in a Murine, Elastase-Induced-COPD Model
Pneumocystis Exacerbates Inflammation and Mucus Hypersecretion in a Murine, Elastase-Induced-COPD Model Open
Inflammation and mucus hypersecretion are frequent pathology features of chronic respiratory diseases such as asthma and COPD. Selected bacteria, viruses and fungi may synergize as co-factors in aggravating disease by activating pathways t…
View article: Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants
Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants Open
RSVpreF vaccine administered during pregnancy was effective against medically attended severe RSV-associated lower respiratory tract illness in infants, and no safety concerns were identified. (Funded by Pfizer; MATISSE ClinicalTrials.gov …
View article: Influence of mental health medication on microbiota in the elderly population in the Valencian region
Influence of mental health medication on microbiota in the elderly population in the Valencian region Open
Spain has an aging population; 19.93% of the Spanish population is over 65. Aging is accompanied by several health issues, including mental health disorders and changes in the gut microbiota. The gut-brain axis is a bidirectional network l…
View article: Nanoplasmonic Avidity-Based Detection and Quantification of IgG Aggregates
Nanoplasmonic Avidity-Based Detection and Quantification of IgG Aggregates Open
Production of therapeutic monoclonal antibodies (mAbs) is a complex process that requires extensive analytical and bioanalytical characterization to ensure high and consistent product quality. Aggregation of mAbs is common and very problem…
View article: Sero-Epidemiology of Pneumocystis Infection among Infants, Children, and Adults in Chile
Sero-Epidemiology of Pneumocystis Infection among Infants, Children, and Adults in Chile Open
Previous serologic surveys show >80% of infants in Chile have anti-Pneumocystis antibodies by 2 years of age, but the seroepidemiology of Pneumocystis infection beyond infancy is unknown. We describe the sero-epidemiology in infants, child…
View article: A Real-Time PCR Assay for Detection of Low Pneumocystis jirovecii Levels
A Real-Time PCR Assay for Detection of Low Pneumocystis jirovecii Levels Open
Here we report a new real-time PCR assay using SYBR Green which provides higher sensitivity for the specific detection of low levels of Pneumocystis jirovecii . To do so, two primer sets were designed, targeting the family of genes that co…
View article: <i>Pneumocystis jirovecii</i> Colonization in Preterm Newborns With Respiratory Distress Syndrome
<i>Pneumocystis jirovecii</i> Colonization in Preterm Newborns With Respiratory Distress Syndrome Open
We describe the prevalence of Pneumocystis jirovecii in mother-infant pairs of very low birth weight newborns <32 weeks gestation. Molecular and microscopic methods were used for detection of P. jirovecii in patients’ specimens. Pneumoc…
View article: Consensus Multilocus Sequence Typing Scheme for Pneumocystis jirovecii
Consensus Multilocus Sequence Typing Scheme for Pneumocystis jirovecii Open
Pneumocystis jirovecii is an opportunistic human pathogenic fungus causing severe pneumonia mainly in immunocompromised hosts. Multilocus sequence typing (MLST) remains the gold standard for genotyping of this unculturable fungus. However,…
View article: Optimized DNA extraction and purification method for characterization of bacterial and fungal communities in lung tissue samples
Optimized DNA extraction and purification method for characterization of bacterial and fungal communities in lung tissue samples Open
Human lungs harbor a scarce microbial community, requiring to develop methods to enhance the recovery of nucleic acids from bacteria and fungi, leading to a more efficient analysis of the lung tissue microbiota. Here we describe five extra…
View article: Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia
Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia Open
Although the role of adaptive immunity in fighting Pneumocystis infection is well known, the role of the innate, airway epithelium, responses remains largely unexplored. The concerted interaction of innate and adaptive responses is essenti…
View article: Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways
Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways Open
Clara cells are the main airway secretory cells able to regenerate epithelium in the distal airways through transdifferentiating into goblet cells, a process under negative regulation of the Notch pathway. Pneumocystis is a highly prevalen…
View article: Pneumocystis primary infection in infancy: Additional French data and review of the literature
Pneumocystis primary infection in infancy: Additional French data and review of the literature Open
Data on features of Pneumocystis primary infection in infancy are still fragmented. To study Pneumocystis primary infection, 192 infants who were monitored for acute pulmonary disease or fever over a 40-month period were retrospectively in…
View article: New DNA Extraction Method for the Detection of<i> Pneumocystis</i> in Lung Tissue Samples of Colonized Individuals
New DNA Extraction Method for the Detection of<i> Pneumocystis</i> in Lung Tissue Samples of Colonized Individuals Open
Background: Pneumocystis jirovecii colonization in patients is associated with a low organism burden, which supports the need to use highly sensitive molecular techniques, such as nested-PCR to determine the presence of the organism. Howev…
View article: Early Acquisition of Pneumocystis jirovecii Colonization and Potential Association With Respiratory Distress Syndrome in Preterm Newborn Infants
Early Acquisition of Pneumocystis jirovecii Colonization and Potential Association With Respiratory Distress Syndrome in Preterm Newborn Infants Open
Pneumocystis jirovecii colonization is frequent in preterm births and could be a risk factor to develop respiratory distress syndrome among preterm infants.
View article: High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy
High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy Open
Mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis jirovecii are associated with the failure of sulfa prophylaxis. They can develop by selection in patients receiving sulfa drugs or be acquired via person-to-person trans…