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View article: Unsupervised Learning Techniques for Breast Lesion Segmentation on MRI Images: Are We Ready for Automation?
Unsupervised Learning Techniques for Breast Lesion Segmentation on MRI Images: Are We Ready for Automation? Open
In the era of precision medicine, increasing importance is given to machine learning (ML) applications. In breast cancer, advanced analyses, such as the radiomic process, characterise tumours and predict therapy responses. Breast magnetic …
View article: Computed tomography-based radiomic to predict resectability in locally advanced pancreatic cancer treated with chemotherapy and radiotherapy
Computed tomography-based radiomic to predict resectability in locally advanced pancreatic cancer treated with chemotherapy and radiotherapy Open
The present radiomic model could help predict resectability in LAPC after neoadjuvant chemotherapy and radiotherapy, potentially integrating clinical and morphological parameters in predicting surgical resection.
View article: Publisher Correction: Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon
Publisher Correction: Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis
Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis Open
Glioblastoma (GBM) is the most malignant brain tumor of adults and is characterized by extensive cell dissemination within the brain parenchyma and enhanced angiogenesis. Effective preclinical modeling of these key features suffers from se…
View article: The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1 Open
Achaete-scute homolog 1 gene (ASCL1) is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the neuronal-like differentiation of GBM cancer stem cells (CSCs) through the activ…
View article: Inside the Developing Brain to Understand Teen Behavior From Rat Models: Metabolic, Structural, and Functional-Connectivity Alterations Among Limbic Structures Across Three Pre-adolescent Stages
Inside the Developing Brain to Understand Teen Behavior From Rat Models: Metabolic, Structural, and Functional-Connectivity Alterations Among Limbic Structures Across Three Pre-adolescent Stages Open
Adolescence is an age of transition when most brain structures undergo drastic modifications, becoming progressively more interconnected and undergoing several changes from a metabolic and structural viewpoint. In the present study, three …
View article: Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and<i>in vivo</i>tumor growth in a highly tumorigenic ovarian cancer model
Phosphatidylcholine-specific phospholipase C inhibition reduces HER2-overexpression, cell proliferation and<i>in vivo</i>tumor growth in a highly tumorigenic ovarian cancer model Open
Antagonizing the oncogenic effects of human epidermal growth factor receptor 2 (HER2) with current anti-HER2 agents has not yet yielded major progress in the treatment of advanced HER2-positive epithelial ovarian cancer (EOC). Using precli…
View article: Theranostic Role of <sup>32</sup>P-ATP as Radiopharmaceutical for the Induction of Massive Cell Death within Avascular Tumor Core
Theranostic Role of <sup>32</sup>P-ATP as Radiopharmaceutical for the Induction of Massive Cell Death within Avascular Tumor Core Open
Drug inaccessibility to vast areas of the tumor parenchyma is amongst the major hurdles for conventional therapies. Treatment efficacy rapidly decreases with distance from vessels and most of the tumor cells survive therapy. Also, between …
View article: Novel cardiac magnetic resonance biomarkers: native T1 and extracellular volume myocardial mapping
Novel cardiac magnetic resonance biomarkers: native T1 and extracellular volume myocardial mapping Open
Cardiac magnetic resonance (CMR) is a non-invasive diagnostic tool playing a key role in the assessment of cardiac morphology and function as well as in tissue characterization. Late gadolinium enhancement is a fundamental CMR technique fo…
View article: T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell–Derived Experimental Glioblastomas
T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell–Derived Experimental Glioblastomas Open
We read with great interest the article by Arevalo-Perez et al, describing the potential value of T1-weighted dynamic contrast-enhanced MR imaging (DCE-MR imaging) as a biomarker for epidermal growth factor receptor variant III (EGFRvIII) …
View article: Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating and immune activation in rostral diencephalon
Mice repeatedly exposed to Group-A β-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating and immune activation in rostral diencephalon Open
Repeated exposure to Group-A β-Haemolytic Streptococcus (GAS) may constitute a vulnerability factor in the onset and course of pediatric motor disturbances. GAS infections/colonization can stimulate the production of antibodies, which may …
View article: Automatic software for extracellular volume fraction mapping in the myocardium
Automatic software for extracellular volume fraction mapping in the myocardium Open
Background CMR is a useful tool for myocardial tissue characterization and to assess fibrosis and edema non-invasively. The estimation of extracellular volume fraction (ECV) is emerging as accurate biomarkers in many cardiac diseases assoc…
View article: Deficient Purposeful Use of Forepaws in Female Mice Modelling Rett Syndrome
Deficient Purposeful Use of Forepaws in Female Mice Modelling Rett Syndrome Open
Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioural and physiological symptoms. Mutations in the methyl CpG binding protein 2 gene ( MECP2 ) cause more than 95% of classic cases. Motor abnormaliti…