Luisa Cutillo
YOU?
Author Swipe
View article: University staff and student perspectives on competent and ethical use of AI: uncovering similarities and divergences
University staff and student perspectives on competent and ethical use of AI: uncovering similarities and divergences Open
We investigated the similarities and differences in understanding among UK-based university staff and students regarding AI literacy, in terms of competent and ethical use of AI tools. This study builds on existing research revealing both …
View article: Gaussian Graphical Modelling Without Independence Assumptions for Uncentered Data
Gaussian Graphical Modelling Without Independence Assumptions for Uncentered Data Open
The independence assumption between random variables is a useful tool to increase the tractability of a modelling framework. However, this assumption can be too simplistic; failing to take dependencies into account can cause models to fail…
View article: Detecting Throat Cancer From Speech Signals Using Machine Learning: A Scoping Literature Review
Detecting Throat Cancer From Speech Signals Using Machine Learning: A Scoping Literature Review Open
Cases of throat cancer are rising worldwide. With survival decreasing significantly at later stages, early detection is vital. Artificial intelligence (AI) and machine learning (ML) have the potential to detect throat cancer from patient s…
View article: <tt>robin2</tt>: accelerating single-cell data clustering evaluation
robin2: accelerating single-cell data clustering evaluation Open
Motivation The rapid expansion of single-cell RNA sequencing (scRNA-seq) technologies has increased the need for robust and scalable clustering evaluation methods. To address these challenges, we developed robin2, an optimized version of o…
View article: A Classification Benchmark for Artificial Intelligence Detection of Laryngeal Cancer from Patient Voice
A Classification Benchmark for Artificial Intelligence Detection of Laryngeal Cancer from Patient Voice Open
Cases of laryngeal cancer are predicted to rise significantly in the coming years. Current diagnostic pathways are inefficient, putting undue stress on both patients and the medical system. Artificial intelligence offers a promising soluti…
View article: Graphical Modelling without Independence Assumptions for Uncentered Data
Graphical Modelling without Independence Assumptions for Uncentered Data Open
The independence assumption is a useful tool to increase the tractability of one's modelling framework. However, this assumption does not match reality; failing to take dependencies into account can cause models to fail dramatically. The f…
View article: Making Multi-Axis Gaussian Graphical Models Scalable to Millions of Samples and Features
Making Multi-Axis Gaussian Graphical Models Scalable to Millions of Samples and Features Open
Gaussian graphical models can be used to extract conditional dependencies between the features of the dataset. This is often done by making an independence assumption about the samples, but this assumption is rarely satisfied in reality. H…
View article: Impact of mother’s childhood trauma on development of psychopathological dimensions in patients with peripartum mental disorders
Impact of mother’s childhood trauma on development of psychopathological dimensions in patients with peripartum mental disorders Open
Introduction Peripartum mental disorders (PPMD) are characterized by heterogeneous psychopathological symptoms related to specific personality traits, which are only taken into account by a few preventive and therapeutic strategies. Trauma…
View article: GRASPS: a simple-to-operate translatome technology reveals omics-hidden disease-associated pathways in TDP-43-related amyotrophic lateral sclerosis
GRASPS: a simple-to-operate translatome technology reveals omics-hidden disease-associated pathways in TDP-43-related amyotrophic lateral sclerosis Open
Transcriptomes and translatomes measure genome-wide levels of total and ribosome-associated RNAs. A few hundred translatomes were reported over >250,000 transcriptomes highlighting the challenges of identifying translating RNAs. Here, we u…
View article: New Horizons in artificial intelligence in the healthcare of older people
New Horizons in artificial intelligence in the healthcare of older people Open
Artificial intelligence (AI) in healthcare describes algorithm-based computational techniques which manage and analyse large datasets to make inferences and predictions. There are many potential applications of AI in the care of older peop…
View article: Identification of genes with oscillatory expression in glioblastoma – The paradigm of<i>SOX2</i>
Identification of genes with oscillatory expression in glioblastoma – The paradigm of<i>SOX2</i> Open
Quiescence, a reversible state of cell-cycle arrest, is an important state during both normal development and cancer progression. For example, in glioblastoma (GBM) quiescent glioblastoma stem cells (GSCs) play an important role in re-esta…
View article: Detecting Throat Cancer from Speech Signals using Machine Learning: A Scoping Literature Review
Detecting Throat Cancer from Speech Signals using Machine Learning: A Scoping Literature Review Open
Introduction: Cases of throat cancer are rising worldwide. With survival decreasing significantly at later stages, early detection is vital. Artificial intelligence (AI) and machine learning (ML) have the potential to detect throat cancer …
View article: ADHD Dimension, Childhood trauma and Perceived Stress: an observational study on peripartum women affected by mood and anxiety disorders
ADHD Dimension, Childhood trauma and Perceived Stress: an observational study on peripartum women affected by mood and anxiety disorders Open
Introduction Pregnancy is an important life event, involving body and mind transformation as well as brain reorganization. ADHD dimension is an additional aggravating factor, albeit poorly studied in the literature, in patients with mental…
View article: Extending bootstrap AMG for clustering of attributed graphs
Extending bootstrap AMG for clustering of attributed graphs Open
In this paper we propose a new approach to detect clusters in undirected graphs with attributed vertices. We incorporate structural and attribute similarities between the vertices in an augmented graph by creating additional vertices and e…
View article: IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy
IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy Open
Glioblastoma (GBM) brain tumours lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumours almost always fatally recur. Using RNAseq data from 107 pairs of pr…
View article: GmGM: a Fast Multi-Axis Gaussian Graphical Model
GmGM: a Fast Multi-Axis Gaussian Graphical Model Open
This paper introduces the Gaussian multi-Graphical Model, a model to construct sparse graph representations of matrix- and tensor-variate data. We generalize prior work in this area by simultaneously learning this representation across sev…
View article: Scalable Bigraphical Lasso: Two-way Sparse Network Inference for Count Data
Scalable Bigraphical Lasso: Two-way Sparse Network Inference for Count Data Open
Classically, statistical datasets have a larger number of data points than features ($n > p$). The standard model of classical statistics caters for the case where data points are considered conditionally independent given the parameters. …
View article: Network Clustering by Embedding of Attribute-augmented Graphs
Network Clustering by Embedding of Attribute-augmented Graphs Open
In this paper we propose a new approach to detect clusters in undirected graphs with attributed vertices. The aim is to group vertices which are similar not only in terms of structural connectivity but also in terms of attribute values. We…
View article: Extending Bootstrap AMG for Clustering of Attributed Graphs
Extending Bootstrap AMG for Clustering of Attributed Graphs Open
In this paper we propose a new approach to detect clusters in undirected graphs with attributed vertices. We incorporate structural and attribute similarities between the vertices in an augmented graph by creating additional vertices and e…
View article: SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Open
BackgroundLoss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing…
View article: Safety and efficacy of <i>C9ORF72</i>-repeat RNA nuclear export inhibition in amyotrophic lateral sclerosis
Safety and efficacy of <i>C9ORF72</i>-repeat RNA nuclear export inhibition in amyotrophic lateral sclerosis Open
Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causin…
View article: ROBustness In Network (robin): an R package for Comparison and\n Validation of communities
ROBustness In Network (robin): an R package for Comparison and\n Validation of communities Open
In network analysis, many community detection algorithms have been developed,\nhowever, their implementation leaves unaddressed the question of the\nstatistical validation of the results. Here we present robin(ROBustness In\nNetwork), an R…
View article: Additional file 5 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
Additional file 5 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis Open
Additional file 5 : Table S4. SRSF1 transcript counts.
View article: Additional file 13 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
Additional file 13 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis Open
Additional file 13 : Table S10. Differentially-expressed transcripts in Drosophila
View article: Additional file 2 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
Additional file 2 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis Open
Additional file 2 : Table S1. RNA-seq statistics.