Luisa Mori
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View article: Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice
Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice Open
Spironolactone (SP), a clinically used aldosterone antagonist, has been explored as an anti-HIV agent in models of HIV-1 latency for inducing transcriptional silencing of the viral reservoir. SP promotes the degradation of xeroderma pigmen…
View article: Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice
Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice Open
Spironolactone (SP), a clinically used aldosterone antagonist, has been explored as an anti-HIV agent in models of HIV-1 latency for inducing transcriptional silencing of the viral reservoir. SP promotes the degradation of xeroderma pigmen…
View article: Dynamics of microcompartment formation at the mitosis-to-G1 transition
Dynamics of microcompartment formation at the mitosis-to-G1 transition Open
As cells exit mitosis and enter G1, chromosomes decompact and transcription is reestablished. Hi-C studies have indicated that all interphase three-dimensional genome features, including A/B compartments, topologically associating domains …
View article: FUBP3 enhances HIV-1 transcriptional activity and regulates immune response pathways in T cells
FUBP3 enhances HIV-1 transcriptional activity and regulates immune response pathways in T cells Open
[This corrects the article DOI: 10.1016/j.omtn.2025.102525.].
View article: Dynamics of microcompartment formation at the mitosis-to-G1 transition
Dynamics of microcompartment formation at the mitosis-to-G1 transition Open
As cells exit mitosis and enter G1, mitotic chromosomes decompact and transcription is reestablished. Previously, Hi-C studies showed that essentially all interphase 3D genome features including A/B-compartments, TADs, and CTCF loops, are …
View article: HIV-1 transcriptional modulation: novel host factors and prospective therapeutic strategies
HIV-1 transcriptional modulation: novel host factors and prospective therapeutic strategies Open
Purpose of review This review highlights advances in HIV transcription and epigenetic latency mechanisms and outlines current therapeutic approaches to eliminate or block the HIV-1 latent reservoir. Recent findings Novel host factors have …
View article: The chaperone protein p32 stabilizes HIV-1 Tat and strengthens the p-TEFb/RNAPII/TAR complex promoting HIV transcription elongation
The chaperone protein p32 stabilizes HIV-1 Tat and strengthens the p-TEFb/RNAPII/TAR complex promoting HIV transcription elongation Open
HIV gene expression is modulated by the combinatorial activity of the HIV transcriptional activator, Tat, host transcription factors, and chromatin remodeling complexes. To identify host factors regulating HIV transcription, we used specif…
View article: The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription, and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency
The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription, and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency Open
Antiretroviral therapy (ART) effectively reduces an individual’s HIV loads to below the detection limit; nevertheless, rapid viral rebound immediately ensues upon treatment interruption. Furthermore, virally suppressed individuals experien…
View article: The Block-and-Lock Strategy for Human Immunodeficiency Virus Cure: Lessons Learned from Didehydro–Cortistatin A
The Block-and-Lock Strategy for Human Immunodeficiency Virus Cure: Lessons Learned from Didehydro–Cortistatin A Open
Antiretroviral therapy effectively controls human immunodeficiency virus (HIV) infection. However, a reservoir of latently infected cells persists under suppressive therapy, constituting a major barrier to an HIV cure. The block-and-lock a…
View article: Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure
Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure Open
HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome. The provirus can then either actively transcribe RNA or enter a latent state, without viral production. The switch between these two states is gover…
View article: Author Correction: Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
Author Correction: Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Modeling HIV-1 Latency Using Primary CD4<sup>+</sup>T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy
Modeling HIV-1 Latency Using Primary CD4<sup>+</sup>T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy Open
Primary cell models of HIV latency have been very useful to identify mechanisms contributing to HIV latency and to evaluate potential HIV cure strategies. However, the current models utilize in vitro infection with exogenous virus that doe…
View article: Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia
Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia Open
These data are consistent with recovery of functional CD4 T-cell responses in ART-treated children, in contrast to relative lack of CD4 T-cell function recovery described in ART-treated adults. However, the challenges of achieving long-ter…